Colon Tumors and Colonoscopy

Abstract

ssssssssssssssssssssssssss s DDW Report ssssssssssssssssssssssssss s Virtual ColonoscopyAdditional prospective studies of the sensitivity and specificity of virtual colonoscopy (VC) have been reported, all of which involve radiologists blinded to the results of conventional colonoscopy (CC). The results were quite mixed. A British group reported that in 201 consecutive patients, VC detected polyps in seven of 14 patients (50 %) with polyps ≥ 1 cm, and in only four of 25 patients (16 %) whose largest polyps were 6 -9 mm [1]. A Japanese group [2] evaluated the sensitivity of VC for right colonic polyps in 58 patients. Five of six polyps > 10 mm (83 %) were detected, but only four of eight (50 %) in the 5 -9 mm range, and there were two flat adenomas and both were missed. A Boston group (Beth Israel Deaconess) studied 100 patients; the sensitivity for polyps ≥ 10 mm was 90 %, and 65 % in the 6 -9 mm range, and at 0 and 24 hours patients reported similar scores for pain and discomfort [3]. The largest study yet performed comparing VC with CC was reported by the Veterans' Association Medical Center in San Francisco [4]. Three hundred patients (291 men, 96 asymptomatic) were studied, of whom 118 had no polyps found by CC. Of these, 33 of 118 had a false-positive finding of polyp on VC. In 182 patients with polyps on CC, VC detected eight of eight cancers (100 %), 90 % of 82 polyps > 1 cm, 80 % of 141 polyps 5 -10 mm, and 59 % of 301 polyps < 5 mm [5].The Mayo Clinic reported an initial experience in tagging stool with barium. In an unblinded study, patients required six or seven doses of 225 ml of dilute barium sulfate over 48 hours to label their stool adequately and detect polyps. The tolerance of this was not reported [6].Overall, the results for virtual colonoscopy continue to be quite mixed, ranging from inadequate to very good. The sensitivity for polyp detection in the 6 -9 mm range is of

Infrared spectral histopathology for cancer diagnosis: a novel approach for automated pattern recognition of colon adenocarcinoma

“…1 Radiation therapy, chemotherapy and surgical intervention have improved the life expectancy of cancer patients, but the outcome of these methods is dependent upon the stage and the accuracy in diagnosis. 2 Currently different detection and screening methods are employed for colorectal cancers, including the fecal occult blood test (FOBT), 3 sigmoidoscopy, 4 colonoscopy, 5 etc. However, the nal diagnosis is settled upon the microscopic examination of the symptomatic tissue with the 'gold standard' histopathology in which preferential stains are used to enhance visualization of the tissue morphological alterations.…”

Diagnosis of colon cancer by attenuated total reflectance-fourier transform infrared microspectroscopy and soft independent modeling of class analogy

“…Despite its superiority in sensitivity and specificity, colonoscopy and histopathological examination are often recommended for secondary screening [2]. Apart from conventional methods of cancer diagnosis [3][4][5][6], there is a need to develop new approaches that are simple, objective, and noninvasive. Infrared (IR) spectroscopy has been suggested as a useful tool in clinical and diagnostic analysis to complement the existing methods because of its potential to probe tissue and cells at the molecular level.…”

Diagnostic potential of Fourier-transform infrared microspectroscopy and advanced computational methods in colon cancer patients

“…Apart from conventional methods of cancer diagnosis, [3][4][5][6] there is a need to develop new approaches which are simple, objective, and noninvasive. Among the optical methods available, Fourier transform infrared ͑FTIR͒ spectroscopy has shown encouraging trends in the field of medicine.…”