Colonic Amyloidosis

Braunstein, Jared; Aman, Ali; Warman, Johnathan

doi:10.1016/j.cgh.2007.02.026

Cited by 2 publications

(2 citation statements)

References 3 publications

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“…The prevalence of radiologic abnormalities is greatest in the small intestine [57]. There may be innumerable fine granular densities or a coarse mucosal appearance, punctuate lucent defects, multiple, sometimes ulcerated nodular polyps, erosions, thickened folds and impaired motor activity [14,[58][59][60].…”

Section: Diagnosismentioning

confidence: 99%

“…A variety of mucosal abnormalities are observed in the GI tract by endoscopy; involvement of the small intestine is especially common (Figure 2). The lesions may appear as a fine granular, granular and nodular mucosa, polypoid protrusions, erosions, ulcerations, mucosal friability, and bowel wall thickening [3,6,57,60]. Tada et al reported endoscopic appearances of gastrointestinal amyloidosis at different location [61].…”

Section: Diagnosismentioning

confidence: 99%

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Clinical management of gastrointestinal amyloidosis

Isomoto¹,

Kamo²,

Chen³

et al. 2012

OJGas

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Amyloidosis is characterized by extracellular deposition of abnormal protein, consisting of primary, secondary, hemodialysis-related, hereditary, senile and localized type. Primary amyloidosis is associated with monoclonal light chains. Secondary amyloidosis is associated with inflammatory, infectious, and neoplastic diseases. Amyloid deposition in the gastrointestinal tract can manifest the symptoms including diarrhea, steatorrhea, or constipation. For diagnosis, one should obtain an immunofixation of serum or urine as well as biopsy sampling of gastrointestinal mucosa stained specifically. While most gastrointestinal complications are managed symptomatically, treatment depends upon the type of amyloidosis. Causal therapy is reserved for a select few from various subtypes of this disorder

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Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Clinical management of gastrointestinal amyloidosis

Isomoto¹,

Kamo²,

Chen³

et al. 2012

OJGas

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Intestinal Amyloidosis with Intractable Diarrhea and Intestinal Pseudo-obstruction

Kim

Park

et al. 2012

Korean J Gastroenterol

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We report herein a case of intestinal amyloidosis with grave prognosis that caused intractable diarrhea and intestinal pseudo-obstruction, alternately in spite of intensive conservative treatment. A 44-year-old woman was admitted for fever, diarrhea, and crampy abdominal pain which had been continuned during 6 months. Abdomen CT scan showed edematous wall thickening of the small bowel and right colon, and colonoscopic biopsy revealed amyloid deposition in the mucosa. Monoclonal light chains in serum and/or urine were not detected and highly elevated serum amyloid A was shown. In spite of intensive treatment including oral prednisolone and colchicine, diarrhea and intestinal pseudo-obstruction developed alternately, general status rapidly got worsened and died after two months.

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Colonic Amyloidosis

Cited by 2 publications

References 3 publications

Clinical management of gastrointestinal amyloidosis

Clinical management of gastrointestinal amyloidosis

Intestinal Amyloidosis with Intractable Diarrhea and Intestinal Pseudo-obstruction

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