Colonic diverticular disease in a multiracial Asian patient population has an ethnic predilection

Abstract

Colonic diverticular disease in a multiracial Asian patient population has an ethnic predilection and is predominantly right-sided.

Demographics and trends in the acute presentation of diverticular disease: a national study

“…recorded a similar finding in a review of colonoscopies undertaken at their institution and postulated that the occurrence of DD at a younger age in non‐European populations may represent the interplay of changing environment in the context of ‘fixed’ genetic factors . Diet and particularly fibre intake are the predominant environmental elements believed to be implicated in the pathogenesis of diverticulosis and may account for the further ethnic predilection observed within the ‘Asian’ population subset . Additionally, Asian populations are more prone to right‐sided DD, which has been shown to present at a younger age than sigmoid disease and may represent a distinct pathophysiological phenomena .…”

Risk of colorectal adenomas, advanced adenomas and cancer in patients with colonic diverticular disease: Systematic review and meta‐analysis

“…Fourteen studies were included in the meta-analysis. [14][15][16][17][18][19][20][21][22][23][24][25][26][27] Figure 1 outlines the search methodology and selection process. Characteristics and quality assessment of the extracted studies are outlined in Table 1.…”

“…Several epidemiological studies attempting to characterize the association between diverticular disease and colorectal cancer have yielded inconsistent results. [14][15][16][17][18][19][20] In particular, a number of studies also assessed the risk of both adenomas and advanced adenomas in patients with diverticular disease, as it is widely regarded that adenomas are the precursor of colorectal cancer. [18][19][20][21][22][23][24][25][26][27] Adenomas are estimated to be present in 20-50% of the US population >50 years.…”

Higher Mortality in Surgically Managed Diverticulitis Is Associated with Asian Ethnicity and Right-Sided Disease

“…5,30,31 the more prevalent sigmoid location of diverticular disease found in the Western world is commonly attributed to a mechanical/motility mechanism, as pulsion diverticula result from intraluminal pressures that are highest in the sigmoid. 32 Differences in disease location based on ethnicity have usually been attributed to diet.…”