Colonic Diverticulosis: From Asymptomatic Form to Major Complications

Miulescu, Ana Maria; Ispas, Alexandru

doi:10.2478/inmed-2018-0011

Cited by 2 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In those over 50, DD has an equal prevalence between sexes. In the under 50 cohort, DD has a male predominance, with young males more likely to have aggressive disease, complications and higher risk of recurrence 11 , 12 . It is hypothesized that the prolonged time course of the bowel wall to insult, rather than age per se , increases the risk of diverticulosis.…”

Section: Epidemiologymentioning

confidence: 99%

“…South-East Asia reports predominantly right-sided true diverticulosis of 70–98% of all cases, peaking in the fifth decade with an overall prevalence between 8 and 25% 10 . Western populations have predominantly left-sided ‘false’ diverticulosis 11 , 12 with over half of DD confined to the sigmoid colon 13 , 14 . False diverticula are an ‘out pouching’ of the mucosa/submucosa as compared with ‘true’ diverticula that contain all layers of the bowel wall.…”

Section: Epidemiologymentioning

confidence: 99%

See 1 more Smart Citation

Genetic, epigenetic and environmental factors in diverticular disease: systematic review

Humphrey,

Sibley,

Walker

et al. 2024

BJS Open

View full text Add to dashboard Cite

Background Diverticulosis is a normal anatomical variant of the colon present in more than 70% of the westernized population over the age of 80. Approximately 3% will develop diverticulitis in their lifetime. Many patients present emergently, suffer high morbidity rates and require substantial healthcare resources. Diverticulosis is the most common finding at colonoscopy and has the potential for causing a significant morbidity rate and burden on healthcare. There is a need to better understand the aetiology and pathogenesis of diverticular disease. Research suggests a genetic susceptibility of 40–50% in the formation of diverticular disease. The aim of this review is to present the hypothesized functional effects of the identified gene loci and environmental factors. Methods A systematic literature review was performed using PubMed, MEDLINE and Embase. Medical subject headings terms used were: ‘diverticular disease, diverticulosis, diverticulitis, genomics, genetics and epigenetics’. A review of grey literature identified environmental factors. Results Of 995 articles identified, 59 articles met the inclusion criteria. Age, obesity and smoking are strongly associated environmental risk factors. Intrinsic factors of the colonic wall are associated with the presence of diverticula. Genetic pathways of interest and environmental risk factors were identified. The COLQ, FAM155A, PHGR1, ARHGAP15, S100A10, and TNFSF15 genes are the strongest candidates for further research. Conclusion There is increasing evidence to support the role of genomics in the spectrum of diverticular disease. Genomic, epigenetic and omic research with demographic context will help improve the understanding and management of this complex disease.

show abstract

Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Genetic, epigenetic and environmental factors in diverticular disease: systematic review

Humphrey,

Sibley,

Walker

et al. 2024

BJS Open

View full text Add to dashboard Cite

show abstract

“…Colorectal polyps may arise from genetic mutations, chronic inflammation, and dietary factors. 12 13 Anthropometric indicators, waist-to-hip ratio (WHR), and body mass index (BMI) indicators of central adiposity have also been linked to an elevated risk of these colorectal disorders. Abdominal fat accumulation is more metabolically active and associated with higher levels of inflammation and insulin resistance than overall body fat.…”

Section: Introductionmentioning

confidence: 99%

The Association between Anthropometric Indicators and Colorectal Polyps and Diverticulosis

Najafi Mobaraki,

Joukar,

Maroufizadeh

et al. 2024

Journal of Coloproctology

View full text Add to dashboard Cite

Introduction Colonic polyps and diverticulosis are common colon findings on colonoscopy. One of the risk factors of colorectal polyps and diverticulosis is the anthropometric index. Therefore, we aimed to investigate the association between the anthropometric index and colorectal findings. Methods In this cross-sectional study, we included 536 patients referred to Razi Hospital, Rasht, Iran, in 2023 for colonoscopy evaluation. Demographical data, clinical characteristics, and colonoscopy findings were recorded for further analysis. All data were analyzed using SPSS.16 by considering a significant level < 0.05 Results The results showed that 35.4% of the patients had polyps, with the majority having a single polyp. The patient's mean age was 55.94 ± 13.33 years; most were females (54.1%). The most common type of polyp was pedunculated, and most were located in the sigmoid colon. The prevalence of diverticular was 11.4%, most of which were also located in the sigmoid colon. Obesity was significantly associated with an increased risk of polyps, while overweight individuals had a higher risk of diverticula (P < 0.05). Age, rural residence, and low physical activity level were identified as factors associated with an increased risk of polyps and diverticula. Conclusion The findings suggest that obesity and overweight are risk factors for polyps and diverticula, respectively. Further research is warranted to explore additional factors and develop preventive strategies for colorectal diseases. These results support the need for preventive strategies and screening programs to reduce the risk of future colorectal lesions.

show abstract

Colonic Diverticulosis: From Asymptomatic Form to Major Complications

Abstract: Introduction This pathology is rare in patients younger than 40 years old (5%) and, in those

Cited by 2 publications

References 6 publications

Genetic, epigenetic and environmental factors in diverticular disease: systematic review

Genetic, epigenetic and environmental factors in diverticular disease: systematic review

The Association between Anthropometric Indicators and Colorectal Polyps and Diverticulosis

Contact Info

Product

Resources

About