2021
DOI: 10.1016/j.jevs.2021.103451
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Colonic Health in Hospitalized Horses Treated with Non-Steroidal Anti-Inflammatory Drugs – A Preliminary Study

Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) can cause right dorsal colitis, but longitudinal clinical studies are lacking. This study investigates whether NSAID treated horses develop right dorsal colonic pathology in a clinical setting. Non-gastrointestinal hospitalized horses treated with NSAIDs > 4 days, and untreated hospital-owned teaching horses and non-gastrointestinal client-owned hospitalized horses were included. All horses were monitored over time with clinical examinations (focusing on presence … Show more

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Cited by 3 publications
(1 citation statement)
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“…Corticosteroids have been the most commonly used pharmaceutical to treat OA in horses for their potent anti-inflammatory and analgesic properties [ 68 ] . However, treatment with NSAIDs and corticosteroids is not entirely benign, as their use has been associated with gastrointestinal compromise and deleterious effects on cartilage, respectively [ 71 73 ] . More recently described treatments in horses and humans include the use of anti-nerve growth factor (anti-NGF) monoclonal antibody [ 54 , 74 ] , as well as gene therapy to specifically antagonize the effects of IL- 1 [ 26 , 75 ] .…”
Section: The Etiopathogenesis Of Oa and The Role Of Inflammationmentioning
confidence: 99%
“…Corticosteroids have been the most commonly used pharmaceutical to treat OA in horses for their potent anti-inflammatory and analgesic properties [ 68 ] . However, treatment with NSAIDs and corticosteroids is not entirely benign, as their use has been associated with gastrointestinal compromise and deleterious effects on cartilage, respectively [ 71 73 ] . More recently described treatments in horses and humans include the use of anti-nerve growth factor (anti-NGF) monoclonal antibody [ 54 , 74 ] , as well as gene therapy to specifically antagonize the effects of IL- 1 [ 26 , 75 ] .…”
Section: The Etiopathogenesis Of Oa and The Role Of Inflammationmentioning
confidence: 99%