2019
DOI: 10.1016/j.ehpc.2019.200323
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Colonic malakoplakia in a liver transplant recipient: A case report

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Cited by 3 publications
(5 citation statements)
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“… 4 Diagnosis can be made by histology with the presence of the large granular, eosinophilic histocytes (von Hansemann cells), and more specifically by the laminated, basophilic, targetoid inclusions (Michaelis-Gutmann bodies), which are stained with periodic acid-Schiff, Von Kossa, and Prussian blue. 2 Immunohistochemically, the cells are positive for CD68, CD163 and alpha-chymotrypsin, confirming their histiocytic nature. 1 Medical treatment strategies are based on antibiotics to eradicate microorganisms and cholinergic agonists to enhance macrophage function.…”
Section: Answermentioning
confidence: 76%
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“… 4 Diagnosis can be made by histology with the presence of the large granular, eosinophilic histocytes (von Hansemann cells), and more specifically by the laminated, basophilic, targetoid inclusions (Michaelis-Gutmann bodies), which are stained with periodic acid-Schiff, Von Kossa, and Prussian blue. 2 Immunohistochemically, the cells are positive for CD68, CD163 and alpha-chymotrypsin, confirming their histiocytic nature. 1 Medical treatment strategies are based on antibiotics to eradicate microorganisms and cholinergic agonists to enhance macrophage function.…”
Section: Answermentioning
confidence: 76%
“… 1 Although commonly seen in the urinary tract, it is also reported in other sites, including the gastrointestinal tract, pancreas, liver, lymph nodes, skin, and respiratory tract. 2 Malakoplakia is associated with dysfunctional bacterial clearance by neutrophils and macrophages, and is thus closely related to immunodeficiency. The most commonly reported microorganisms in patients with malakoplakia are Escherichia coli , Proteus , Mycobacterium tuberculosis , and Staphylococcus aureus .…”
Section: Answermentioning
confidence: 99%
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“…Treatment will often involve antibiotics, specifically quinolones (eg, ciprofloxacin), which can target macrophages and destroy the microorganism 13. Another medical therapy, which has been mentioned in the literature, would be the use of cholinergic agonists such as bethanechol and ascorbic acid to improve the bactericidal activity within macrophages 13 14. Surgery will be an important consideration if there is a mass or intestinal perforation 14…”
Section: Discussionmentioning
confidence: 99%
“…Another medical therapy, which has been mentioned in the literature, would be the use of cholinergic agonists such as bethanechol and ascorbic acid to improve the bactericidal activity within macrophages 13 14. Surgery will be an important consideration if there is a mass or intestinal perforation 14…”
Section: Discussionmentioning
confidence: 99%