Colonic Motility in the Irritable Bowel Syndrome

Burns, Theodore W.

doi:10.1001/archinte.1980.00330140105027

Cited by 18 publications

(6 citation statements)

References 45 publications

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“…However, the exact relationship between the specific patterns of changes in gastrointestinal motility and IBS symptoms is still unclear, and the mechanism involved is poorly understood. Gut motility can be modulated by a variety of factors including food intake, physical activity levels, the autonomic nervous system, gastrointestinal hormones, and emotional and psychological factors (Burns, 1980). Gastrointestinal hormones and neurotransmitters play different roles under specific conditions.…”

Section: Introductionmentioning

confidence: 99%

Shugan Decoction Alleviates Colonic Dysmotility in Female SERT-Knockout Rats by Decreasing M3 Receptor Expression

et al. 2020

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Background: Irritable bowel syndrome (IBS) is a functional gut disease characterized by visceral hypersensitivity and gut motor dysfunction. Serotonin (5-hydroxytryptamine, 5-HT) is an important enteric neurotransmitter. High levels of 5-HT aggravate IBS symptoms. The serotonin reuptake transporter (SERT) is a membrane-embedded transporter involved in IBS pathogenesis that plays an important role in regulating 5-HT signaling. Aim: We investigated whether gut motor function was altered in SERT-knockout (SERT-KO) rats. Additionally, we sought to determine whether Shugan decoction (SGD), a clinically experienced prescription for the treatment of IBS, exerts regulatory effects on intestinal motility in SERT-KO rats, and attempted to identify the mechanisms involved. Method: SERT-KO rats were produced by transcription activator-like effector nuclease (TALEN) technology. Fecal pellet output was measured for ten consecutive days to estimate distal colonic motility. Small intestinal motility was measured by charcoal-meal experiments. The colonic and small intestinal muscle contractile activities were measured by organ bath study. Western blot was used to analyze the muscarinic receptor expression in colon tissue.

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Section: Introductionmentioning

confidence: 99%

Shugan Decoction Alleviates Colonic Dysmotility in Female SERT-Knockout Rats by Decreasing M3 Receptor Expression

et al. 2020

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“…[1][2][3][4][5] It was originally considered that this abnormality was confined to the colon, but subsequent studies have shown both oesophageal6 and small intestinal involvement. 7 We have recently reported that compared with healthy controls patients with irritable bowel syndrome complain of a significant number of urinary symptoms such as frequency, nocturia, and urgency.8 It is not known, however, whether this reflects an intrinsic abnormality of bladder smooth muscle or is related to extrinsic compression associated with the gut problem.…”

mentioning

confidence: 99%

Bladder smooth muscle dysfunction in patients with irritable bowel syndrome.

Whorwell¹,

Lupton²,

Erduran³

et al. 1986

Gut

128

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“…However, previous investigations reported regular con- tractile frequency patterns occurring in colons of healthy humans (2,4,9). These regular frequencies (in particular, the three-cycles-per-minute rhythm), like myoelectrical frequencies, are thought to be of importance in some functional colonic disease, such as the irritable bowel syndrome (4,5,21,22). Most of the above cited studies were performed in the rectosigmoid area, which may not be truly representative of the whole colon (23).…”

Section: Discussionmentioning

confidence: 99%

Contractile Frequency Patterns of the Human Colon

Bassotti

Bucaneve

Pelli

et al. 1990

Neurogastroenterology Motil

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Unlike myoelectrical frequency patterns, the regular contractile activity of the human colon in vivo is poorly understood, especially with regard to the proximal portions of the viscus. For this reason, we looked for contractile patterns (defined as a regular sequence of waves occurring consecutively for at least 2 minutes, at various frequencies) in prolonged (24‐hour) manometric recordings obtained in 20 healthy volunteers of both sexes. Manometric investigations were done by means of a colonoscopically positioned multilumen poly‐vinylcloride (PVC) probe and low‐compliance infusion system. Systematic analysis of the tracings showed that regular contractile activity is scarce in the human colon, in that it accounts for only about 6% of total contractile activity; contractile patterns vary in frequency from two to eight cycles per minute, with three cycles per minute (which represents 80% of regular activity) predominating; regular contractile activity is chiefly encountered in the distal (descending and sigmoid) colon, where it represents about 50% of motility; and unlike the human upper gut and anorectal area, and the dog colon, the regular activity of the human colon is not organized in a cyclic fashion.

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Colonic Motility in the Irritable Bowel Syndrome

Cited by 18 publications

References 45 publications

Shugan Decoction Alleviates Colonic Dysmotility in Female SERT-Knockout Rats by Decreasing M3 Receptor Expression

Shugan Decoction Alleviates Colonic Dysmotility in Female SERT-Knockout Rats by Decreasing M3 Receptor Expression

Bladder smooth muscle dysfunction in patients with irritable bowel syndrome.

Contractile Frequency Patterns of the Human Colon

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