Colonic Mucosa-Associated Lymphoid Tissue Lymphoma

Abstract

Colonic mucosa-associated lymphoid tissue (MALT) lymphomas are rare and a definitive treatment has not been established. Solitary or multiple, elevated or polypoid lesions are the usual appearances of MALT lymphoma in the colon and sometimes the surface may reveal abnormal vascularity. In this paper we report our experience with four cases of colonic MALT lymphoma and review the relevant literature. The first patient had a smooth elevated lesion in the rectum and histopathologic examination of the biopsy from the lesion showed centrocyte-like cells infiltrating the lamina propria. Endoscopic ultrasonography (EUS) revealed thickening of the submucosa and muscularis propria. The patient underwent radiation therapy, and 9 months later a repeat colonoscopy showed complete resolution of the lesion. In case 2, colonoscopy showed a polyp in the cecum; the biopsy was diagnostic of MALT lymphoma. EUS detected a hypoechoic lesion confined to the mucosal layer of the colonic wall. The patient underwent endoscopic mucosal resection of the lesion and after 6 years of follow-up there was no evidence of recurrence. The third patient had a sessile elevated lesion in the sigmoid colon for which she underwent sigmoidectomy. Pathological examination of the surgical specimen was suggestive of MALT lymphoma. The last patient had a smooth elevated lesion in the rectum and magnification endoscopy showed irregular vascular pattern. The patient underwent endoscopic submucosal dissection, and biopsy examination showed the tumor to be MALT lymphoma. Although rare, awareness of MALT lymphoma of the colon is important to evaluate the patient appropriately and to plan further management.

Regression of Cecal MALT Lymphoma after Antibiotic Treatment in a Patient with <i>Helicobacter pylori</i> Infection

“…To the best of our knowledge, only six cases of primary cecal MALT lymphoma have been published in the English language literature. The reported cases are summarized in Table (15,(17)(18)(19)(20)(21). Surgical or endoscopic resection was performed in most reported cases.…”

Synchronous MALT lymphoma of the colon and stomach and regression after eradication ofStrongyloides stercoralisandHelicobacter pylori

“…MALT lymphomas can arise anywhere along the GIT and account for 23% of all primary GI NHLs, but most MALT lymphomas arise in the stomach. Colorectal MALT lymphomas are very rare, accounting for less than 1% of large bowel malignancies 6. Even rarer are synchronous MALT lymphomas of the stomach and colon 5 7–9…”

Immune protective mechanism of rMOMP protein ophthalmic vaccine regarding intraocular hypertension and retinal optic nerve injury in rats

“…The vessels in the palpebral conjunctiva have intensive distribution and rich blood supply. There are two mesh lymphatic systems in superficial and deep layers, respectively, which are crucial local mucosal-associated lymphoid tissues (Akasaka et al, 2012;McCollum et al, 2012;Saito et al, 2012). Glaucoma and optic nerve injury can lead to progressive death of retinal ganglion cells (RGCs) and loss of optic nerve fibers, which is one of the essential reasons for such diseases inducing blindness (BrignoleBaudouin et al, 2012).…”