Colonic perforation in Behçet’s syndrome

Abstract

A 17-year-old gentleman was admitted to our hospital for headache, the differential diagnosis of which included Behçet's syndrome (BS). He developed an acute abdomen and was found to have air under the diaphragm on erect chest X-ray. Subsequent laparotomy revealed multiple perforations throughout the colon. This report describes an unusual complication of Behcets syndrome occurring at the time of presentation and a review of the current literature of reported cases.

Kolon perforasyonunda histomorfolojik tanı güçlükleri

“…Bu hastalarda ileoçekal bölge tutulumu yaklaşık %75'dir (6). Vakaların %1'inden daha azında ülseratif değişiklikler görülür (17). İntestinal ülserler, aftöz ya da derin ve zımba deliğine benzer ("punched-out") yuvarlak ve oval görünümdedir (7,15).…”

“…Ülserasyonlar lokalize ve diffüz biçimde iki tipte oluşabilir (6). Ülserler penetrasyon, perforasyon ve kanamaya sebep olabilir (14,17). Ülserli hastaların %50'inde perforasyon ve penetrasyon oluşur (14).…”

“…Ülserli hastaların %50'inde perforasyon ve penetrasyon oluşur (14). Cerrahi rezeksiyondan sonra rekürrens yaygındır (17). 6-A, B).…”

Colonic perforation as an unusual manifestation of Behcet's disease

“…Ozbiljne manifestacije bolesti razvijaju se kod oko 25% bolesnika i to ireverzibilni vaskulitis krvnih sudova retine kod 15%, tromboembolijske komplikacije na velikim krvnim sudovima kod 8,5%, zahvatanje centralnog nervnog sistema kod 3,2-8%, gastrointenstinalne manifestacije kod 2,8-7,6%, perforacija creva kod 1% i letalan ishod bolesti kod 2% bolesnika [4][5][6][7][8] . Većina opisanih slučajeva sa gastrointestinalnim manifestacijama je iz zemalja istočnog Mediterana i iz Japana gde je i prevalencija Behčetove bolesti najveća 3,4 .…”

Ileum and colon perforations in a young patient with Behçet’s disease

“…Deep ulcers in the GI tract that are seen in BD are the major causes of severe complications, such as severe bleeding and perforation. There are only a few studies that have reported colonic perforations due to BD (2,3). In this article, we report a patient with BD who underwent an emergent operation because of acute abdomen, developing secondary to multiple perforations of the ascending colon and terminal ileum.…”