Colonisation by  Streptococcus pneumoniae  and  Staphylococcus aureus  in healthy children

Bogaert, Debby; Belkum, Alex van; Sluijter, Marcel; Luijendijk, Ad; Groot, Ronald de; Rümke, H. C.; Verbrugh, Henri A.; Hermans, Peter W. M.

doi:10.1016/s0140-6736(04)16357-5

Cited by 542 publications

(517 citation statements)

References 5 publications

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“…(a) Clusters outlined in red represent samples that group together at 50% similarity, whereas clusters outlined in gray represent 80% similarity. S. aureus and S. pneumoniae is negatively correlated in the nasopharynx (Bogaert et al, 2004). However, whereas Streptococcus species are dominant in the nasopharynx (Pettigrew et al, 2008) and various skin habitats (Gao et al, 2007;Fierer et al, 2008), this study shows that they are only in low abundance in the anterior nares, a feature also supported by previous culture-dependent studies (Lina et al, 2003).…”

Section: Discussionsupporting

confidence: 85%

A poke into the diversity and associations within human anterior nare microbial communities

et al. 2010

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The anterior nares are the major reservoir for Staphylococcus aureus in humans, where nasal carriage has a crucial function as a source for invasive infections. Despite various investigations on aerobic community members based on traditional cultivation methods, little is known on the overall microbial composition and complex in situ interactions, but such knowledge is highly warranted for effective S. aureus control strategies. As assessed using advanced culture-independent approaches, this study provides a comprehensive survey of the anterior nare bacterial community of 40 individuals. Previously undiscovered co-colonization patterns and natural variations in species composition were revealed and provide insights for future intervention strategies for the control of health-care-and community-associated S. aureus infections.

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Section: Discussionsupporting

confidence: 85%

A poke into the diversity and associations within human anterior nare microbial communities

et al. 2010

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“…aureus in older children (20.6 %) than in younger children (12.2 %), resembling the peak incidence of Staph. aureus carriage at 10 years of age among children in other studies (Bogaert et al, 2004b;Regev-Yochay et al, 2004). Collectively, these epidemiological data support the view that the significant increase in Staph.…”

Section: Association Between Colonization Of the Four Bacteriasupporting

confidence: 83%

Nasal colonization by four potential respiratory bacteria in healthy children attending kindergarten or elementary school in Seoul, Korea

Bae

Lee

et al. 2012

Journal of Medical Microbiology

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A longitudinal analysis was carried out of the colonization by four potential respiratory pathogens -Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus -in 165 healthy children (aged 3-7 years) attending three kindergartens and 417 healthy children (aged 7-10 years) attending an elementary school in Seoul, Korea, by four consecutive examinations over 1 year. The prevalence of nasal carriers of one or more of four bacteria was found to be higher in younger children (¡7 years) (mean 68.6 %) than that in older children (mean 46.8 %). The mean rates of nasal carriage of Strep. pneumoniae, H. influenzae, M. catarrhalis and Staph. aureus were 16.8, 18.9, 20.2 and 18.2 %, respectively. Colonization by Strep. pneumoniae, H. influenzae and M. catarrhalis was higher in pre-school children (28.6, 32.4 and 35.0 %, respectively) than in school children (12.2, 13.6 and 14.3 %, respectively). Carriage trends differed with age, with Strep. pneumoniae, H. influenzae and M. catarrhalis colonization decreasing with age but Staph. aureus colonization increasing. Positive associations of co-occurrence between Strep. pneumoniae, H. influenzae and M. catarrhalis were evident, with a significant negative association evident between Staph. aureus and the other three bacteria. A better understanding of the colonization and interaction of potential respiratory pathogens may be important for predicting changes in bacterial ecology and for designing control strategies that target bacterial colonization in upper respiratory tract infections.

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“…When children were diagnosed pneumonia infected by S. pneumoniae, linkage of Pseudomonas and Arthrobacter to other bacterial colonizers were implicated to be broken up. This could be due to attachment of respiratory epithelial cells and evading host defenses by S. pneumoniae (16) through abundant various virulence factors like polysaccharide capsule and hydrogen peroxide, suggesting inhibitory effect of S. pneumoniae on other bacterial counterparts like S. aureus (17,18). Enrichment of S. pneumoniae in D1 group was also supported by clinical diagnosis based on traditional culture, and detection of M. pneumoniae in D2 group by single real time PCR, implicating accuracy of analysis results.…”

Section: Previously Identified Microbial Colonizers Of Lung Includingmentioning

confidence: 99%

Mycoplasma pneumoniae and Streptococcus pneumoniae caused different microbial structure and correlation network in lung microbiota

Wang

Dai²,

Qiu

et al. 2016

J. Thorac. Dis.

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Pneumonia is one of the most serious diseases for children, with which lung microbiota are proved to be associated. We performed 16S rDNA analysis on broncho-alveolar lavage fluid (BALF) for 32 children with tracheomalacia (C group), pneumonia infected with Streptococcus pneumoniae (S. pneumoniae) (D1 group) or Mycoplasma pneumoniae (M. pneumoniae) (D2 group). Children with tracheomalacia held lower microbial diversity and accumulated Lactococcus (mean ± SD, 45.21%±5.07%, P value <0.05), Porphyromonas (0.12%±0.31%, P value <0.05). D1 and D2 group were enriched by Streptococcus (7.57%±11.61%, P value <0.01 when compared with D2 group) and Mycoplasma (0.67%±1.25%, P value <0.01) respectively.Bacterial correlation in C group was mainly intermediated by Pseudomonas and Arthrobacter. Whilst, D1 group harbored simplest microbial correlation in three groups, and D2 group held the most complicated network, involving enriched Staphylococcus (0.26%±0.71%), Massilia (0.81%±2.42%). This will be of significance for understanding pneumonia incidence and progression more comprehensively, and discerning between bacterial infection and carriage.

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Colonisation by Streptococcus pneumoniae and Staphylococcus aureus in healthy children

Cited by 542 publications

References 5 publications

A poke into the diversity and associations within human anterior nare microbial communities

A poke into the diversity and associations within human anterior nare microbial communities

Nasal colonization by four potential respiratory bacteria in healthy children attending kindergarten or elementary school in Seoul, Korea

Mycoplasma pneumoniae and Streptococcus pneumoniae caused different microbial structure and correlation network in lung microbiota

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