2004
DOI: 10.1128/aem.70.2.1176-1181.2004
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Colonization and Immunomodulation by Lactobacillus reuteri ATCC 55730 in the Human Gastrointestinal Tract

Abstract: Lactobacillus reuteri ATCC 55730 is a probiotic (health-promoting) bacterium widely used as a dietary supplement. This study was designed to examine local colonization of the human gastrointestinal mucosa after dietary supplementation with L. reuteri ATCC 55730 and to determine subsequent immune responses at the colonized sites. In this open clinical investigation, 10 healthy volunteers and 9 volunteers with ileostomy underwent gastroscopy or ileoscopy and biopsy samples were taken from the stomach, duodenum, … Show more

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Cited by 303 publications
(239 citation statements)
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“…The administration of L. acidophilus 74-2 at a dose of 2.8 Â 10 9 cfu/day and B. lactis 420 at a dose of 9.0 Â 10 8 cfu/day over 5 weeks was well tolerated by the subjects and resulted in a significant increase in faecal bacterial counts of both species. Studies that investigated biopsy specimens from different parts of the gastrointestinal tract and faecal samples showed a clear correlation between the appearance of the bacteria in the biopsy samples and their presence in faeces (Ouwehand et al, 2004;Valeur et al, 2004;Van der Waaij et al, 2005). These observations allow the assumption that the significant elevated faecal counts of both administered probiotic bacteria indicate transient colonization.…”
Section: Discussionmentioning
confidence: 87%
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“…The administration of L. acidophilus 74-2 at a dose of 2.8 Â 10 9 cfu/day and B. lactis 420 at a dose of 9.0 Â 10 8 cfu/day over 5 weeks was well tolerated by the subjects and resulted in a significant increase in faecal bacterial counts of both species. Studies that investigated biopsy specimens from different parts of the gastrointestinal tract and faecal samples showed a clear correlation between the appearance of the bacteria in the biopsy samples and their presence in faeces (Ouwehand et al, 2004;Valeur et al, 2004;Van der Waaij et al, 2005). These observations allow the assumption that the significant elevated faecal counts of both administered probiotic bacteria indicate transient colonization.…”
Section: Discussionmentioning
confidence: 87%
“…These observations allow the assumption that the significant elevated faecal counts of both administered probiotic bacteria indicate transient colonization. Furthermore, Valeur et al (2004) stated that an increase in faecal bacterial counts is a traditional indication of colonization. Interestingly, L. acidophilus was detected in 30.8% (eight out of 26 volunteers), whereas B. lactis was found in 88.5% (23 out of 26 volunteers) after probiotic intake.…”
Section: Discussionmentioning
confidence: 99%
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“…With the many publications showing beneficial effects of probiotic bacteria, there has been an increasing interest in the mechanism behind. Most clinical studies have tested only one dose of probiotics, ranging from 4 Â 10 8 CFU/day for determination of gastrointestinal colonization and immune modulation (Valeur et al, 2004) Contributors: DCE, CNL and KFM wrote the protocol. DCE performed the study.…”
Section: Introductionmentioning
confidence: 99%
“…With the many publications showing beneficial effects of probiotic bacteria, there has been an increasing interest in the mechanism behind. Most clinical studies have tested only one dose of probiotics, ranging from 4 Â 10 8 CFU/day for determination of gastrointestinal colonization and immune modulation (Valeur et al, 2004) up to 10 11 CFU/day in infant formula given to allergic children (Isolauri et al, 2000). In a meta-analysis of the therapeutic effect of lactobacilli on acute diarrhea a dose-response effect was suggested (Van Niel et al, 2002).…”
Section: Introductionmentioning
confidence: 99%