Colonization of <i>Helicobacter pylori</i> in the gastric cardia: A comparison between the UFT300 and CLO tests

Liao, Po-Hao; Lin, Yu‐Chun; Chu, Cheng‐Hsin; Shih, Shou-Chuan; Liou, Tai-Cherng

doi:10.1002/jgh3.12053

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…Concerning the endoscopic findings, the crater of peptic ulcer and the inflammation of cardia might influence the eradication rate of ILTHPI due to endoscopic difficult locations for the procedures of ILTHPI including the irrigation of mucus and the application of medicaments. In addition, endoscopic hyperemic change and positive UFT300 of gastric cardia may indicate a higher bacterial load in the cardia [36], leading to failure of ILTHPI. Our study showed that the eradication rate of ILTHPI was not influenced by the presence of peptic ulcer, endoscopic hyperemic change of gastric cardia, and positive UFT300 of gastric cardia.…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting the Intraluminal Therapy for Helicobacter pylori Infection

Liu

Lin

et al. 2022

Microorganisms

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Helicobacter pylori (H. pylori) can be eradicated immediately while conducting an endoscopic examination. The eradication rate of intraluminal therapy for H. pylori infection (ILTHPI) is 53.7% (51/95) via local application of single-dose medicament containing amoxicillin, metronidazole, and clarithromycin. We aimed to evaluate factors affecting ILTHPI and to assess the efficacy among single antibiotics, and compared our results with combined antibiotics. We enrolled H. pylori-infected treatment-naïve symptomatic patients; 95 completed triple-antibiotic ILTHPI were evaluated for risk factors, along with 60 completed mono-antibiotic ILTHPI containing amoxicillin, clarithromycin, or metronidazole in each of the 20 patients. Univariate analysis revealed the significant influence of BMI (OR: 1.15; 95% CI: 1.03–1.27, p = 0.011) and gastric juice pH (OR: 1.35; 95% CI: 1.16–1.58, p = 0.0001). Logistic regression analysis also showed significant influence of gastric juice pH (OR: 1.30; 95% CI: 1.10–1.54, p = 0.002). The eradication rate of mono-antibiotic ILTHPI is significantly lower than triple-antibiotic ILTHPI (11.7% vs. 53.7%; p < 0.0001; α = 0.05, power = 1.0). The efficacy was 20% (4/20) for metronidazole, 10% (2/20) for amoxicillin, and 5% (1/20) for clarithromycin. In conclusion, the level of gastric juice pH is a crucial factor affecting the ILTHPI. The detection of gastric juice pH and selection of optimal intraluminal medicaments are important. Further studies with combined antibiotics for ILTHPI, perhaps metronidazole-containing medicaments, are recommended.

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Section: Discussionmentioning

confidence: 99%

Factors Affecting the Intraluminal Therapy for Helicobacter pylori Infection

Liu

Lin

et al. 2022

Microorganisms

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“…Persistent H. pylori colonization resulting in subsequent chronic inflammation of cardia has been established in many studies. The rate of colonization detected by rapid urease test in gastric cardia was 90% in H. pylori -infected patients [ 6 ], and was also significantly higher in patients with cardiac cancer (81.5%) and gastric carditis (80.1%) [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Gastric Juice pH on the Intraluminal Therapy for Helicobacter pylori Infection

Wang

Chen

et al. 2020

JCM

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Background: Helicobacter pylori (H. pylori) can be topically eradicated in stomach lumen on endoscopic examination. The procedures of intraluminal therapy for H. pylori infection (ILTHPI) include the control of intragastric pH, mucolytic irrigation of the gastric mucosal surface, and a single-dose medicament containing antimicrobial agents. Aims: To detect gastric juice pH and evaluate its impact on the success rate of ILTHPI. Methods: We enrolled 324 patients with upper abdominal discomfort for endoscopic examinations. Among them, 13C-urea breath test was positive in 218 patients, where 100 underwent ILTHPI, and negative in 106. All patients had their gastric juice pH detected and set into three ranges, including normal acidity (pH < 4.0), low-level hypoacidity (pH 4.0–5.5), and high-level hypoacidity (pH ≥ 6.0). The impact of gastric juice pH on the success rate of ILTHPI was evaluated. Results: Distribution of pH level showed no significant difference between two groups of H. pylori-infected patients (p = 0.942). The eradication rate of ILTHPI is significantly lower in patients with gastric juice pH below 4 (p < 0.001). Conclusions: Detection of gastric juice pH in ILTHPI is extremely important. Rapid control of stomach pH at or above 4 for patients prior to ILTHPI is strongly recommended. (NCT03124420).

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“…The significance of the cardia in Hp pathogenesis remains largely understudied. Some studies have noted that the gastric cardia was one of the most consistently colonized regions of the stomach in Hp-infected patients, as determined endoscopically ( Genta et al, 1994a ; Liao et al, 2018 ). It remains to be seen whether the cardia indeed represents a preferential site for initial Hp colonization, like the corpus-antrum transition.…”

Section: Introductionmentioning

confidence: 99%

Follow the Metaplasia: Characteristics and Oncogenic Implications of Metaplasia’s Pattern of Spread Throughout the Stomach

Sáenz

2021

Front. Cell Dev. Biol.

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The human stomach functions as both a digestive and innate immune organ. Its main product, acid, rapidly breaks down ingested products and equally serves as a highly effective microbial filter. The gastric epithelium has evolved mechanisms to appropriately handle the myriad of injurious substances, both exogenous and endogenous, to maintain the epithelial barrier and restore homeostasis. The most significant chronic insult that the stomach must face is Helicobacter pylori (Hp), a stomach-adapted bacterium that can colonize the stomach and induce chronic inflammatory and pre-neoplastic changes. The progression from chronic inflammation to dysplasia relies on the decades-long interplay between this oncobacterium and its gastric host. This review summarizes the functional and molecular regionalization of the stomach at homeostasis and details how chronic inflammation can lead to characteristic alterations in these developmental demarcations, both at the topographic and glandular levels. More importantly, this review illustrates our current understanding of the epithelial mechanisms that underlie the pre-malignant gastric landscape, how Hp adapts to and exploits these changes, and the clinical implications of identifying these changes in order to stratify patients at risk of developing gastric cancer, a leading cause of cancer-related deaths worldwide.

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Colonization of Helicobacter pylori in the gastric cardia: A comparison between the UFT300 and CLO tests

Cited by 4 publications

References 18 publications

Factors Affecting the Intraluminal Therapy for Helicobacter pylori Infection

Factors Affecting the Intraluminal Therapy for Helicobacter pylori Infection

The Impact of Gastric Juice pH on the Intraluminal Therapy for Helicobacter pylori Infection

Follow the Metaplasia: Characteristics and Oncogenic Implications of Metaplasia’s Pattern of Spread Throughout the Stomach

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