Colonization prevalence and antibiotic susceptibility of Group B Streptococcus in pregnant women over a 6-year period in Dongguan, China

Abstract

This study investigated the prevalence of recto-vaginal Group B Streptococcus (GBS) colonization, serotype distribution, and antimicrobial susceptibility patterns among pregnant women in Dongguan, China. Recto-vaginal swabs were collected from pregnant women at gestational age 35-37 weeks between January 1 st 2009 and December 31 st 2014. Isolates were serotyped by latex-agglutination and were tested against seven antimicrobials by disk diffusion. Of 7,726 pregnant women who completed GBS testing, 636 (8.2%) were GBS carriers. Of 153 GBS isolates available for typing, 6 serotypes (Ia, Ib, III, V, VI and VIII) were identified with type III being predominant, while 9 (5.9%) were non-typable isolates. All isolates were sensitive to penicillin, ceftriaxone, linezolid and vancomycin, whereas 52.4% were resistant to clindamycin, 25.9% were resistant to levofloxacin and 64.9% were resistant to erythromycin. This study showed the recto-vaginal colonization prevalence of GBS in Dongguan is significant. Due to 100% susceptibility to penicillin of all GBS samples, penicillin remains the first recommendation for treatment and prevention against GBS infection. Susceptibility testing should be performed for women allergic to penicillin in order to choose the most appropriate antibacterial agents for treatment and prevention of vertical transmission to neonates. In addition, we suggest establishing standard processes for GBS culture and identification in China as early as possible.

Group B streptococcal colonization in mothers and infants in western China: prevalences and risk factors

“…Our study demonstrates that the GBS colonization rate in pregnant Chinese women in Liuzhou was 6.1%, which is similar to the reported rate of 7.1% in Beijing [ 9 ] and 8.2% in Dongguan [ 10 ]. Our rate is similar to those of other Asian countries including Philippines (7.5%) [ 11 ], Japan (8.2%) [ 12 ], Myanmar (7.1%) [ 11 ] and South Korea (8.0%) [ 13 ].…”

Antibiotic Resistance and Molecular Epidemiological Characteristics of Streptococcus agalactiae Isolated from Pregnant Women in Guangzhou, South China

“…ese guidelines generally recommend that pregnant women with S. agalactiae colonization should receive intrapartum antibiotic prophylaxis (IAP) to reduce the incidence of these infections [9,10]. Currently, there are no official guidelines for S. agalactiae screening and prevention in China [5,11]. However, in recent years, S. agalactiae has become an important pathogen in Chinese obstetrics and neonatology [12].…”

“…e first-line antibiotic for IAP is penicillin [9,10]; however, since some people are allergic to it, macrolides (e.g., erythromycin) and lincosamides (e.g., clindamycin) are used as the alternative antibiotics [14]. Unfortunately, the resistance of S. agalactiae to macrolides and lincosamides is increasing worldwide [4,9,11,15,16]. Previous studies have shown that the ermB, ermTR, and mefA/E genes are involved in the resistance to macrolides [17], and the linB gene has been linked to the resistance to lincosamides and moderate sensitivity to macrolides [18].…”

Antimicrobial Susceptibility Test for the Determination of Resistant and Susceptible S. aureus and Enterococcus spp. Using a Multi-Channel Surface Plasmon Resonance Device

“…Various standardized phenotypic antimicrobial susceptibility testing methods such as agar diffusion [11], broth microdilution [12], gradient strip tests [13], and disk diffusion [14] have traditionally been used by researchers to determine whether the bacteria are resistant or susceptible. Resistance to specific antibiotics can also be determined by PCR, which investigates the presence or absence of genes responsible for the resistance [15].…”