Colonoscopy - Health Gains But Heart Strains?

Hyperprolactinaemia and mental illnessThe recent review by Bushe et al. 1 upon hyperprolactinaemia and mental illness draws attention to the short-and long-term sequelae of the administration of antipsychotic agents. In addition to this iatrogenic form of hyperprolactinaemia, we would wish to draw attention to the fact that hyperprolactinaemia due to dopamine deficiency is seen in certain inherited conditions such as deficiencies of tyrosine hydroxylase, aromatic amino acid decarboxylase and tetrahydrobiopterin (BH4) deficiency. With regard to the latter this may not always be the case due to incomplete penetrance of the mutations. 2 Moreover, in those patients where prolactin is raised, the measurement of serum prolactin is a useful surrogate for monitoring treatment. As suggested by Bushe et al., the monitoring of patients with BH4 deficiency states should also include assessment of bone density and cancer risk especially if therapeutic responses are inadequate.References; Land and Heales, Hyperprolactinaemia.

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“…Contributorship: The colonoscopy study was carried out by George et al 1 . AB was involved in analysing the samples.…”

Section: Declarationsmentioning

confidence: 99%

“…To calculate the 99th percentile URL, we statistically analysed the results of basal cardiac Troponin I (cTnI) concentrations in samples collected from 198 patients (114 male, 84 female, age range 30–94 y) recruited into a study looking at the cardiac effects of colonoscopy. 1,2…”

mentioning

confidence: 99%