Colonoscopy reduced distal colorectal cancer risk and excess cancer risk associated with family history

Morois, Sophie; Cottet, Vanessa; Racine, Antoine; Clavel‐Chapelon, Françoise; Carbonnel, Franck; Bastide, Nadia; Boutron‐Ruault, Marie‐Christine

doi:10.1007/s10552-014-0438-7

Cited by 16 publications

(24 citation statements)

References 35 publications

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“…Another 17 studies were further excluded for reasons listed as follows: baseline population above average risk ( n =1) ( 46 ), not all polyps removed ( n =1) ( 47 ), effect estimates of interest not reported ( n =5) ( 17 , 48 , 49 , 50 , 51 ), effect estimates of interest not adjusted ( n =1) ( 52 ), different definition of outcome ( n =1) ( 53 ), and same data source ( n =8) ( 25 , 27 , 54 , 55 , 56 , 57 , 58 , 59 ). Finally, 11 studies were included in the meta-analysis ( 18 , 19 , 28 , 29 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ).…”

Section: Resultsmentioning

confidence: 99%

“…Details of the 11 included studies are listed in Table 1 . Of the 11 observational studies, 5 were cohort studies ( 18 , 60 , 61 , 62 , 63 ) (3 prospective ( 18 , 60 , 61 ) and 2 retrospective ( 62 , 63 )) and 6 were case–control studies ( 19 , 28 , 29 , 64 , 65 , 66 ). A total of 1,499,521 individuals were included, in which 1 study enrolled over 1,000,000 individuals ( 62 ), 7 studies enrolled 10,000–100,000 individuals each ( 18 , 28 , 60 , 61 , 63 , 64 , 65 ), and the other 3 enrolled <10,000 individuals each ( 19 , 29 , 66 ).…”

Section: Resultsmentioning

confidence: 99%

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Colonoscopy Reduces Colorectal Cancer Incidence and Mortality in Patients With Non-Malignant Findings: A Meta-Analysis

Pan

Xin

et al. 2016

American Journal of Gastroenterology

126

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OBJECTIVES:Observational studies have shown that colonoscopy reduces colorectal cancer (CRC) incidence and mortality in the general population. We aimed to conduct a meta-analysis quantifying the magnitude of protection by colonoscopy, with screening and diagnostic indications, against CRC in patients with non-malignant findings and demonstrating the potentially more marked effect of screening over diagnostic colonoscopy.METHODS:PubMed, EMBASE, and conference abstracts were searched through 30 April 2015. The primary outcomes were overall CRC incidence and mortality. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated using random-effect models.RESULTS:Eleven observational studies with a total of 1,499,521 individuals were included. Pooled analysis showed that colonoscopy was associated with a 61% RR reduction in CRC incidence (RR: 0.39; 95% CI: 0.26–0.60; I2=93.6%) and a 61% reduction in CRC mortality (RR: 0.39; 95% CI: 0.35–0.43; I2=12.0%) in patients with non-malignant findings, although there was high heterogeneity for the outcome of CRC incidence. After excluding one outlier study, there was low heterogeneity for the outcome of incidence (I2=44.7%). Subgroup analysis showed that the effect of screening colonoscopy was more prominent, corresponding to an 89% reduction in CRC incidence (RR: 0.11; 95% CI: 0.08–0.15), in comparison with settings involving diagnostic colonoscopy (RR: 0.51; 95% CI: 0.43–0.59; P<0.001).CONCLUSIONS:On the basis of this meta-analysis of observational studies, CRC incidence and mortality in patients with non-malignant findings are significantly reduced after colonoscopy. The effect of screening colonoscopy on CRC incidence is more marked than diagnostic colonoscopy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Colonoscopy Reduces Colorectal Cancer Incidence and Mortality in Patients With Non-Malignant Findings: A Meta-Analysis

Pan

Xin

et al. 2016

American Journal of Gastroenterology

126

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“…In a German case-control study of CRC patients with an FHCC, those who had had a prior colonoscopy had a lower CRC risk that individuals without a family history who had not undergone colonoscopy. In the E3N French prospective study of 92 078 women, 692 CRCs were diagnosed after a median follow-up of 15.4 years31 ; women with FHCC who had not had a previous colonoscopy had a 80% higher CRC risk than those without FHCC. In women who had had a previous colonoscopy, CRC risk was similar in women with and without FHCC.…”

Section: Family History Of Crc (Fhcc)mentioning

confidence: 99%

Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG)

Monahan

Bradshaw²,

Dolwani

et al. 2019

Gut

335

375

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Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost 30% of the population in the UK have a family history of CRC. The quantification of an individual’s lifetime risk of gastrointestinal cancer may incorporate clinical and molecular data, and depends on accurate phenotypic assessment and genetic diagnosis. In turn this may facilitate targeted risk-reducing interventions, including endoscopic surveillance, preventative surgery and chemoprophylaxis, which provide opportunities for cancer prevention. This guideline is an update from the 2010 British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland (BSG/ACPGBI) guidelines for colorectal screening and surveillance in moderate and high-risk groups; however, this guideline is concerned specifically with people who have increased lifetime risk of CRC due to hereditary factors, including those with Lynch syndrome, polyposis or a family history of CRC. On this occasion we invited the UK Cancer Genetics Group (UKCGG), a subgroup within the British Society of Genetic Medicine (BSGM), as a partner to BSG and ACPGBI in the multidisciplinary guideline development process. We also invited external review through the Delphi process by members of the public as well as the steering committees of the European Hereditary Tumour Group (EHTG) and the European Society of Gastrointestinal Endoscopy (ESGE). A systematic review of 10 189 publications was undertaken to develop 67 evidence and expert opinion-based recommendations for the management of hereditary CRC risk. Ten research recommendations are also prioritised to inform clinical management of people at hereditary CRC risk.

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“…The beginning of screening for colorectal lesions for the average-risk population is recommended at age 50 by many gastrointestinal professionals societies (Ness et al, 2000;Thoma et al, 2011). Studies regarding the effectiveness of CRC screening program support the benefit of screening programs as a means of decreasing morbidity and mortality of CRC (Winawer et al, 1993;Levin et al, 2008;Rex et al, 2009;Morois et al, 2014). According to Neugut et al and Liberman et al; colonoscopy is a more efficient method of CRC detection compared to fecal occult blood, double contrast enema and sigmoidoscopy (Lieberman et al, 2000;Rex et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Colorectal Polyps in a Group of Subjects at Average-risk of Colorectal Cancer Undergoing Colonoscopic Screening in Tehran, Iran between 2008 and 2013

Sohrabi¹,

Zamani²,

Ajdarkosh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Colorectal cancer (CRC) is one of the prime causes of mortality around the globe, with a significantly rising incidence in the Middle East region in recent decades. Since detection of CRC in the early stages is an important issue, and also since to date there are no comprehensive epidemiologic studies depicting the Middle East region with special attention to the average risk group, further investigation is of significant necessity in this regard. Aim: Our aim was to investigate the prevalence of preneoplastic and neoplastic lesions of the colon in an average risk population. Materials and Methods: A total of 1,208 eligible asymptomatic, average-risk adults older than 40 years of age, referred to Firuzgar Hospotal in the years 2008-2012, were enrolled. They underwent colonoscopy screening and all polypoid lesions were removed and examined by an expert gastrointestinal pathologist. The lesions were classified by size, location, numbers and pathologic findings. Size of lesions was measured objectively by endoscopists. Results: The mean age of participants was 56.5 ± 9.59 and 51.6% were male. The overall polyp detection rate was 199/1208 (16.5 %), 26 subjects having non-neoplastic polyps, including hyperplastic lesions, and 173/1208 (14.3%) having neoplastic polyps, of which 26 (2.15%) were advanced neoplasms .The prevalence of colorectal neoplasia was more common among the 50-59 age group. Advanced adenoma was more frequent among the 60-69 age group. The majority of adenomas were detected in the distal colon, but a quarter of advanced adenomas were found in the proximal colon; advance age and male gender was associated with the presence of adenoma. Conclusions: It seems that CRC screening among average-risk population might be recommended in countries such as Iran. However, sigmioidoscopy alone would miss many colorectal adenomas. Furthermore, the 50-59 age group could be considered as an appropriate target population for this purpose in Iran.

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Colonoscopy reduced distal colorectal cancer risk and excess cancer risk associated with family history

Abstract: Results showed colonoscopy ability to prevent distal cancers, but not proximal cancers in women. Colonoscopy screening also reduced the excess risk of women with FHCC to that of women with no FHCC.

Cited by 16 publications

References 35 publications

Colonoscopy Reduces Colorectal Cancer Incidence and Mortality in Patients With Non-Malignant Findings: A Meta-Analysis

Colonoscopy Reduces Colorectal Cancer Incidence and Mortality in Patients With Non-Malignant Findings: A Meta-Analysis

Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG)

Prevalence of Colorectal Polyps in a Group of Subjects at Average-risk of Colorectal Cancer Undergoing Colonoscopic Screening in Tehran, Iran between 2008 and 2013

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