Colonoscopy screening markedly reduces the occurrence of colon carcinomas and carcinoma-related death: a closed cohort study

Manser, Christine N.; Bachmann, Lucas M.; Brunner, Jakob; Hunold, Fritz; Bauerfeind, Peter; Marbet, Urs A.

doi:10.1016/j.gie.2012.02.040

Cited by 123 publications

(97 citation statements)

References 20 publications

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“…Indeed, numerous studies have shown that colonoscopic removal of adenomatous polyps prevents CRC development and CRC-associated deaths. [1][2][3][4] A German, single-center study reported a 2.43% CRC prevalence during diagnostic colonoscopy (presence of symptoms indicative of CRC or a positive FOBT result before colonoscopy) and 0.9% during screening colonoscopy (absence of symptoms indicative of CRC). The benefit of screening colonoscopy is attributed to polyp resection, but data on long-term followup of patients diagnosed with CRC during screening colonoscopy are limited.…”

mentioning

confidence: 99%

Survival in patients with colorectal cancer diagnosed by screening colonoscopy

Friedrich

Grüter

Gotthardt

et al. 2015

Gastrointestinal Endoscopy

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confidence: 99%

Survival in patients with colorectal cancer diagnosed by screening colonoscopy

Friedrich

Grüter

Gotthardt

et al. 2015

Gastrointestinal Endoscopy

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“…Finally, the overall pollution condition of China is under degradation, some poisonous substance may be absorbed into bodies, which can be a potential carcinogenic factor (Hoff et al, 2009;Johnson et al, 2013). Last, Chinese people' s living standard has greatly improved, people pay more attention to their health, especially in urban areas, so cancer screening program is widely popularized, so the detection rate of colorectal cancer can be increased especially the use of colonoscope (Winawer et al, 1993;Citarda et al, 2001;Baxter et al, 2009;Hoff et al, 2009;Atkin et al, 2010;Singh et al, 2010;Manser et al, 2012;Zauber et al, 2012). In some countries, including of developing countries, computed tomography colonography is also applied, which is a great help to clinicians.…”

Section: Discussionmentioning

confidence: 99%

“…In China, colorectal cancer is a devastating health threat, factors that protect people from CRC are also well established. Several studies during the past years have demonstrated that endoscopic screening is the most important factor, not only in reducing the incidence of CRC, but also in decreasing CRC-related mortality ( Winawer et al, 1993;Citarda et al, 2001;Baxter et al, 2009;Hoff et al, 2009;Atkin et al, 2010;Singh et al, 2010;Manser et al, 2012;Zauber et al, 2012). Lots of companies and official departments have requested all the staffs more than 45 years old to receive colonscopy and serum tumor markers exams annually, which maybe to some extent help decrease the colon cancer morbidity and mortality.…”

Section: Discussionmentioning

confidence: 99%

Colorectal Cancer Incidence and Mortality in China, 2010

Zheng

Zheng²,

Zhang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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(ASRcn) and World standard population (Segi's population, ASRwld) for incidence were 16.1/100,000 and 15.9/100,000 respectively. There were 132,110 cases estimated to have died from colorectal cancer in China in 2010 (76,646 men and 55,464 women) with the crude mortality rate of 10.1/100,000. The ASRcn and ASRwld for mortality were 7.55/100,000 and 7.44/100,000 respectively, higher in males and urban areas than in females and rural areas. The incidence and mortality rates increased with age, reaching peaksin the 80-84 year old, and oldest age groups, respectively. Conclusions: Colorectal cancer is one of the most common incident cancers and cause of cancer death in China. Primary and secondary prevention, with attention to a health lifestyle, physical activity and screening should be enhanced in the general population.

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“…Colonoscopy remains the most complete screening procedure, permitting visualization of the complete colonic tract and simultaneous polypectomy, and is the gold standard against which other screening methods are measured. Studies have shown colonoscopy to reduce by an estimated 50% the incidence of CRC, and an inverse correlation between colonoscopy use and death from CRC [67][68][69][70][71][72] . A recent study also found colonoscopy and sigmoidoscopy to be associated with a lower mortality from CRC of the distal colon, and colonoscopy associated with decreased mortality from proximal CRC [69] .…”

Section: Screening Techniques-colonoscopymentioning

confidence: 99%

Genomic era diagnosis and management of hereditary and sporadic colon cancer

Snyder

2014

WJCO

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The morbidity and mortality attributable to heritable and sporadic carcinomas of the colon are substantial and affect children and adults alike. Despite current colonoscopy screening recommendations colorectal adenocarcinoma (CRC) still accounts for almost 140000 cancer cases yearly. Familial adenomatous polyposis (FAP) is a colon cancer predisposition due to alterations in the adenomatous polyposis coli gene, which is mutated in most CRC. Since the beginning of the genomic era next-generation sequencing analyses of CRC continue to improve our understanding of the genetics of tumorigenesis and promise to expand our ability to identify and treat this disease. Advances in genome sequence analysis have facilitated the molecular diagnosis of individuals with FAP, which enables initiation of appropriate monitoring and timely intervention. Genome sequencing also has potential clinical impact for individuals with sporadic forms of CRC, providing means for molecular diagnosis of CRC tumor type, data guiding selection of tumor targeted therapies, and pharmacogenomic profiles specifying patient specific drug tolerances. There is even a potential role for genomic sequencing in surveillance for recurrence, and early detection, of CRC. We review strategies for diagnostic assessment and management of FAP and sporadic CRC in the current genomic era, with emphasis on the current, and potential for future, impact of genome sequencing on the clinical care of these conditions. © 2014 Baishideng Publishing Group Inc. All rights reserved.Key words: Colorectal adenocarcinoma; Familial adenomatous polyposis; Genome sequencing; Personalized medicine; Cancer genomics; Pharmacogenomics; Genomic medicine Core tip: The era of genomic sequencing is beginning to make significant impact on the diagnosis and management of sporadic and inherited colorectal adenocarcinoma (CRC) such as familial adenomatous polyposis. This review will discuss the current guidelines for diagnosis and management of CRC and how genomic sequencing is enabling earlier definitive diagnosis with associated intensive surveillance and preventative interventions, molecular tumor characterization directing tumor specific therapy, germline patient genome analysis which informs individual drug tolerance and efficacy, and is evolving to develop post-treatment surveillance, with the potential to ultimately decrease the current prevalence and mortality of CRC, sporadic and hereditary.Esplin ED, Snyder MP. Genomic era diagnosis and management of hereditary and sporadic colon cancer. World J Clin Oncol 2014; 5(5): 1036-1047 Available from: URL: http://www. wjgnet.com/2218-4333/full/v5/i5/1036.htm DOI: http://dx.doi. org/10.5306/wjco.v5.i5.1036 INTRODUCTIONThe annual incidence in the United States of colorectal adenocarcinoma (CRC) is almost 140000 [1] . The morbidi- ty and mortality attributable to heritable and sporadic carcinomas of the colon are substantial and affect children and adults alike, with CRC being the third highest cause of cancer mortality among men and wom...

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Colonoscopy screening markedly reduces the occurrence of colon carcinomas and carcinoma-related death: a closed cohort study

Cited by 123 publications

References 20 publications

Survival in patients with colorectal cancer diagnosed by screening colonoscopy

Survival in patients with colorectal cancer diagnosed by screening colonoscopy

Colorectal Cancer Incidence and Mortality in China, 2010

Genomic era diagnosis and management of hereditary and sporadic colon cancer

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