Colonoscopy versus Fecal Immunochemical Testing in Colorectal-Cancer Screening

Abstract

Subjects in the FIT group were more likely to participate in screening than were those in the colonoscopy group. On the baseline screening examination, the numbers of subjects in whom colorectal cancer was detected were similar in the two study groups, but more adenomas were identified in the colonoscopy group. (Funded by Instituto de Salud Carlos III and others; ClinicalTrials.gov number, NCT00906997.).

S3-Leitlinie – Kolorektales Karzinom

“…In einzelnen randomisierten Studien konnte zudem gezeigt werden, dass trotz geringerer Teilnahmerate im Vergleich zum FOBT durch sowohl Sigmoidoskopie [103] als auch Koloskopie [104] in einer intention-to-screen-Analyse mehr fortgeschrittene Neoplasien detektiert werden, was vor allem durch die deutlich höhere Sensitivität für fortgeschrittene Adenome bedingt war. …”

Colorectal Cancer Screening by Double Contrast Barium Enema in Thai People

“…In a recent study of average-risk US population, the diagnostic yield of DCBE for advanced adenoma and CRC was 6.2% and 0.7%, respectively (Kung et al, 2006). Meanwhile, the incidence of colorectal neoplasm detected during screening colonoscopy and fecal immunochemical testing in a large number of asymptomatic European adults 50 to 69 years of age was 1.9% and 0.9% for advanced adenoma, and 0.1% for CRC, respectively (Quintero et al, 2012). Technique of barium study and the interpretation of the findings on DCBE examination by radiologists also affect the accuracy of CRC detection.…”

Editorial: Colorectal Cancer Screening Education in Medically Vulnerable Populations: the Role of the Journal of Cancer Education

“…Despite the availability of various CRC screening options, the fact is that half of all US adults aged 50 years or more are not up to date with national screening guidelines, and screening rates are particularly low among vulnerable groups, such as the medically underserved, racial/ethnic minorities, and recent immigrants [12].…”

“…Immune fecal occult blood testing (iFOBT) is a relatively new, cheaper, more accessible, yet still effective screening alternative, which is cost effective while still resulting in a 30 % reduction in CRC mortality [12]. It may be both more acceptable than colonoscopy to immigrants and more practical for underserved patients, who are often treated in federally qualified health centers (FQHCs) where colonoscopy is often not available [13].…”