Colony stimulating factors (including erythropoietin, granulocyte colony stimulating factor and analogues) for stroke

Bath, Philip M.W.; Sprigg, Nikola; England, Timothy J.

doi:10.1002/14651858.cd005207.pub3

Cited by 24 publications

(25 citation statements)

References 26 publications

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“…In addition, interventions with drugs that target inflammatory responses poststroke need a wide knowledge of brain–immune interactions. Currently, trials of candidate stroke drugs that interfere with the immune system, such as the granulocyte-colony stimulating factor (G-CSF) or albumin are under way 10 25…”

Section: Discussionmentioning

confidence: 99%

The impact of lesion location and lesion size on poststroke infection frequency

Minnerup

Wersching

Brokinkel

et al. 2009

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Discussionmentioning

confidence: 99%

The impact of lesion location and lesion size on poststroke infection frequency

Minnerup

Wersching

Brokinkel

et al. 2009

Journal of Neurology, Neurosurgery & Psychiatry

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“…However, even though CSFR2A is higher in males with stroke compared to control males in this study, CSF2RA mRNA is reported to be higher in normal females compared to normal males [13]. Since GM-CSF induces angiogenesis, improves cerebral blood flow and protects against ischemic injury [25, 26], this may suggest that GM-CSF modulation of the vasculature via CSFR2A may be more important in females than males. SPRY3 was also up regulated in males.…”

Section: Discussionmentioning

confidence: 73%

Y Chromosome Gene Expression in the Blood of Male Patients With Ischemic Stroke Compared With Male Controls

Tian¹,

Stamova²,

Jickling³

et al. 2012

Gender Medicine

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Background and Purpose Gender is suggested to be an important determinant of ischemic stroke risk factors, etiology and outcome. However, the basis for this remains unclear. The Y chromosome is unique in males. Genes expressed in men on the Y chromosome that are associated with stroke may be important genetic contributors to the unique features of males with ischemic stroke, which would be helpful for explaining sex differences observed between men and women. Methods Blood samples were obtained from 40 males at ≤ 3, 5 and 24 hours following ischemic stroke and from 41 male controls (July 2003- April 2007). RNA was isolated from blood and processed on Affymetrix Human U133 Plus 2.0 Arrays. Y chromosome genes differentially expressed between male stroke and male control subjects were identified using an analysis of covariance (ANCOVA) adjusted for age and batch. A p<0.05 and fold change (FC) > ∣1.2∣ were considered significant. Results Seven genes on the Y chromosome were differentially expressed in males with ischemic strokes compared to controls. Five of these genes (VAMP7, CSF2RA, SPRY3, DHRSX, PLCXD1,) are located on pseudoautosomal regions (PARs) of the human Y chromosome. The other two genes (EIF1AY and DDX3Y) are located on the non-recombining region of the human Y chromosome (NRY). The identified genes were associated with immunology, RNA metabolism, vesicle fusion and angiogenesis. Conclusions Specific genes on the Y chromosome are differentially expressed in blood following ischemic stroke. These genes provide insight into potential molecular contributors to sex differences in ischemic stroke.

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“…Astrocytic hIGF-1 elevated circulating levels of granulocyte colony-stimulating factor (GCSF), which is reported to be neuroprotective (Bath and Sprigg 2007; Fan et al 2015; Shin and Cho 2016), as well as IL-4 and IL-5, which are associated with the Th2 immune response and correlates with reduction in infarct volume (Luo et al 2015). Peripheral inflammation in stroke patients, usually caused by infection, worsens stroke outcomes (Grau et al 1999).…”

Section: Discussionmentioning

confidence: 99%

Astrocyte‐specific insulin‐like growth factor‐1 gene transfer in aging female rats improves stroke outcomes

Okoreeh

Bake

Sohrabji

2017

Glia

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Middle aged female rats sustain larger stroke infarction and disability than younger female rats. This older group also shows age-related reduction of insulin like growth factor (IGF)-1 in serum and in astrocytes, a cell type necessary for post stroke recovery. To determine the impact of astrocytic IGF-1 for ischemic stroke, these studies tested the hypothesis that gene transfer of IGF-1 to astrocytes will improve stroke outcomes in middle aged female rats. Middle aged (10–12 month old), acyclic female rats were injected with recombinant adeno-associated virus serotype 5 (AAV5) packaged with the coding sequence of the human (h)IGF-1 gene downstream of an astrocyte-specific promoter GFAP (AAV5-GFP-hIGF-1) into the striatum and cortex. The AAV5-control consisted of an identical shuttle vector construct without the hIGF-1 gene (AAV5-GFAP-control). Six to eight weeks later, animals underwent transient (90 mins) middle cerebral artery occlusion via intraluminal suture. While infarct volume was not altered, AAV5-GFAP-hIGF-1 treatment significantly improved blood pressure and neurological score in the early acute phase of stroke (2 days) and sensory-motor performance at both the early and late (5 days) acute phase of stroke. AAV5-GFAP-hIGF-1 treatment also reduced circulating serum levels of GFAP, a biomarker for blood brain barrier permeability. Flow cytometry analysis of immune cells in the brain at 24h post stroke showed that AAV5-GFAP-hIGF-1 altered the type of immune cells trafficked to the ischemic hemisphere, promoting an anti-inflammatory profile. Collectively, these studies show that targeted enhancement of IGF-1 in astrocytes of middle-aged females improves stroke-induced behavioral impairment and neuroinflammation.

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Colony stimulating factors (including erythropoietin, granulocyte colony stimulating factor and analogues) for stroke

Cited by 24 publications

References 26 publications

The impact of lesion location and lesion size on poststroke infection frequency

The impact of lesion location and lesion size on poststroke infection frequency

Y Chromosome Gene Expression in the Blood of Male Patients With Ischemic Stroke Compared With Male Controls

Astrocyte‐specific insulin‐like growth factor‐1 gene transfer in aging female rats improves stroke outcomes

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