Color and pulsed doppler sonography, grayscale imaging, and serum CA 125 in the assessment of adnexal disease

Abstract

Color and pulsed Doppler sonography, which demonstrate a tumor angiogenic activity, are as accurate as gray-scale imaging in the assessment of adnexal lesions. Together with serum CA 125 marker levels, they produce high negative predictive values, providing reassurance that an adnexal mass is benign.

Receiver operating characteristic curves of transvaginal Doppler blood flow measurements in benign and malignant adnexal tumors.

“…In a study of 63 benign tumors, Prömpeler and coauthors 8 found a sensitivity in detecting benign tumors of 91% for a PSV ≥ 30 cm/s. 8 In a study that included seven malignant tumors, Predanic and coworkers 6 found the mean PSV to be 8.3 cm/s, with a sensitivity of 85%, a specificity of 71%, a PPV of 21%, and an NPV of 98% in detecting benign tumors. 6 In our study, the mean PSV in malignant tumors was 12.4 cm/s.…”

“…8 In a study that included seven malignant tumors, Predanic and coworkers 6 found the mean PSV to be 8.3 cm/s, with a sensitivity of 85%, a specificity of 71%, a PPV of 21%, and an NPV of 98% in detecting benign tumors. 6 In our study, the mean PSV in malignant tumors was 12.4 cm/s. With a PSV of ≥18 cm/s sensitivity in predicting malignancy was 13%, specificity was 86%, PPV was 31%, NPV was 66%, and accuracy was 62%.…”

Investigating infertility

“…[4][5][6][7][8] Serum CA 125 concentrations can also be misleading-results may be falsely positive in women with conditions that affect the peritoneal surface, such as endometriosis and pelvic infection. 9 10 Because epithelial ovarian malignancy is rare in this age group, other tumour markers, such as α fetoprotein, lactate dehydrogenase, and serum β human chorionic gonadotrophin, should be investigated to rule out germ cell tumours.…”

Transvaginal color Doppler assessment of venous flow in adnexal masses

“…Although some authors have found this technique useful [2][3][4][5][6][7][8][9][10] , others have questioned these results [11][12][13][14][15][16][17] .…”