Color Doppler Evaluation of the Retrobulbar Hemodynamic Changes in Chronic Obstructive Pulmonary Disease

Çelik, Cihan; Tokgöz, Özlem; Şerifoğlu, İsmail; Tor, Meltem; Alpay, Atilla; Erdem, Zühal

doi:10.1177/0161734613514391

Cited by 9 publications

(14 citation statements)

References 22 publications

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“…Chronic hypoxia and hypercapnia may affect the retinal and choroidal blood flow in COPD patients. In this regard, some color Doppler ultrasonography studies have demonstrated impaired retrobulbar hemodynamics, reduced retrobulbar blood flow, and increased resistance to blood flow in both the retinal and choroidal circulation in COPD patients [ 29 – 31 ].…”

Section: Discussionmentioning

confidence: 99%

Choroid and Retinal Nerve Fiber Layer Thickness in Patients with Chronic Obstructive Pulmonary Disease Exacerbation

Kocamış

Zorlu

2018

Journal of Ophthalmology

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Purpose We aimed at measuring the choroid and retinal nerve fiber layer thickness with optic coherence tomography (OCT) in patients diagnosed with chronic obstructive pulmonary disease (COPD). Methods A total of 60 patients with COPD and 23 healthy controls were evaluated in the scope of this prospective, observational study. COPD patients were divided into two groups as those that were stable and those with an exacerbation based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification. Subfoveal choroid thickness (SFCT) of the patients and the control group was compared by measuring the choroid thickness at points 1000 µm nasal and temporal to the fovea and the mean retinal nerve fiber layer (RNFL) thickness. Results The subfoveal choroid thickness of the COPD patients in both the exacerbation and stable groups was found to be statistically significantly thinner than the control group (p=0.047 and p=0.046, resp.). No statistically significant difference was found between the subfoveal choroid thickness of the patients that were stable and those that had an exacerbation (p=0.813). No statistically significant difference was found between the mean RNFL, 1000 µm nasal, or 1000 µm temporal choroid thicknesses of the COPD patients and the control group (p=0.263, p=0.455, and p=0.611, resp.). Conclusion Decreased subfoveal choroid thickness was found in the COPD patients both during an exacerbation and in the stable period, when compared to the control group. The mean RNFL thickness was similar in the exacerbation and stable period of the stable COPD patients when compared to the control group. This suggests that ocular findings might be important in terms of COPD morbidity. This trial is registered with www.chictr.org.cn/enIndex.aspx.

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Section: Discussionmentioning

confidence: 99%

Choroid and Retinal Nerve Fiber Layer Thickness in Patients with Chronic Obstructive Pulmonary Disease Exacerbation

Kocamış

Zorlu

2018

Journal of Ophthalmology

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“…Meydana gelen kronik hipoksi ve hiperkapninin oküler arterler üzerindeki etkilerini ele alan çalışmalara da literatürde rastlamaktayız [10,11]. Akciğerler ve hava yollarındaki enflamasyonun yanısıra, mekanizması kesin olmamakla birlikte sistemik bir enflamasyon geliştiği de gösterilmiştir.…”

Section: Discussionunclassified

Kronik obstrüktif akciğer hastalığında orbital kan akım değişikliklerinin renkli doppler ultrasonografi ile değerlendirilmesi

Çetin¹,

Arslan²,

Şalk³

et al. 2014

Cumhuriyet Med J

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Obstructive Lung Disease (GOLD) criteria into four groups were enrolled in our study. Each group included 20 patients. Total of 63 healthy people selected randomly were accepted as control group. Peak systolic velocity (PSV), end diastolic velocity (EDV) and resistive index (RI) were calculated in the central retinal artery (CRA) and the ophthalmic artery (OA) respectively. The flow velocity of central retinal vein (CRV) was also measured. All of measurements were obtained for patients and control groups. Results. PSV and RI values of CRA and OA were significantly higher in the patient groups (p<0.05). But there was no statistically significance in EDV values (p>0.05). Furthermore significant increase of CRV measurements was detected (p<0.05). Conclusion. We thought that the changes of PSV and RI parameter in CRA and OA depend on hypoxia with COPD causes systemic and local inflammatory metabolites due to distortion of retinal auto regulatory mechanism. The elevation increase CRV is attributed to amount of blood return to the ophthalmic vein by means of ocular blood flow increase, and to the increased central venous blood pressure related to COPD.

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“…Furthermore, no significant differences were found in PSV and EDV between patients with COPD and control subjects (Celik et al. ). However, it has been recognized that both PSV and EDV can be influenced by Doppler angle, whereas RI is independent of the Doppler angle (Platt et al.…”

Section: Methodsmentioning

confidence: 99%

“…Changes in PSV, EDV and RI are associated with various vascular disorders, and have predictive value for coronary artery diseases (Tranquart et al 2003;Maruyoshi et al 2010). Three studies used colour Doppler ultrasonography with patients with COPD, showing an increased PSV, EDV, and RI values of the ophthalmic artery (OA), central retinal artery (CRA) and posterior ciliary artery (PCA) in patients with COPD compared to non-COPD control subjects (Ozer et al 2006;Celik et al 2014;Yakut et al 2015). Ozer et al (2006) determined RI, pulsatility index (PI), PSV and EDV in the OA, CRA and PCA in 45 male patients with COPD and 17 male controls.…”

Section: Colourmentioning

confidence: 99%

Looking into the eye of patients with chronic obstructive pulmonary disease: an opportunity for better microvascular profiling of these complex patients

Vaes

Spruit

Theunis

et al. 2018

Acta Ophthalmologica

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Chronic obstructive pulmonary disease (COPD) is a complex disease with many patients suffering from cardiovascular comorbidity. However, cardiovascular diseases remain often undiagnosed in COPD. Assessment of the retinal microvasculature can provide value in cardiovascular profiling of these patients. Retinal microvascular assessment carried out via a noninvasive eye exam represents an easy to use tool when examining patients with COPD. The purpose of this review was to provide an overview of studies assessing structural and functional changes in the retinal microvasculature of patients with COPD. Findings demonstrated that structural and functional microvascular changes were more common and severe in COPD patients as compared to non-COPD controls, although few retinal investigations have been performed in patients with COPD. As cardiovascular comorbidities are highly prevalent in COPD, we advocate more research to investigate the value of an eye exam for microvascular phenotyping of COPD patients.

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Color Doppler Evaluation of the Retrobulbar Hemodynamic Changes in Chronic Obstructive Pulmonary Disease

Cited by 9 publications

References 22 publications

Choroid and Retinal Nerve Fiber Layer Thickness in Patients with Chronic Obstructive Pulmonary Disease Exacerbation

Choroid and Retinal Nerve Fiber Layer Thickness in Patients with Chronic Obstructive Pulmonary Disease Exacerbation

Kronik obstrüktif akciğer hastalığında orbital kan akım değişikliklerinin renkli doppler ultrasonografi ile değerlendirilmesi

Looking into the eye of patients with chronic obstructive pulmonary disease: an opportunity for better microvascular profiling of these complex patients

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