Color Doppler flow imaging of hepatic focal nodular hyperplasia

Kudo, Masatoshi; Tomita, S; Minowa, K; Tochio, Hitoshi; Shimada, Ken; Mimura, Jun; Okabe, Yoshihiro; Kashida, Hiroshi; Hirasa, Masahiro; Todo, Akio

doi:10.7863/jum.1992.11.10.553

Cited by 15 publications

(9 citation statements)

References 4 publications

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“…9,24 Therefore the total controls and patients with chronic liver disease based on CT, whereas the counts and counts per unit hepatic volume based amounts of ASGP-R are lower in patients with chronic liver disease than in normal individuals. 25 The ASGP-R concentra-on Tc-99m GSA in the entire liver significantly decreased in patients with more extensive liver disease (Fig.…”

Section: Aid Hepa 0025mentioning

confidence: 99%

Hepatic lobar differences in progression of chronic liver disease: Correlation of asialoglycoprotein scintigraphy and hepatic functional reserve

et al. 1997

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SAKAE MATSUZAKI, MASAHIKO ONDA, TAKASHI TAJIRI, AND DEOG Y. KIM mammalian hepatocytes. The indices obtained from We studied the hepatic functional reserve in the lobes GSA planar imaging correlate with conventional indicators of the liver in 28 patients with chronic liver disease and for hepatic functional reserve, eg, serum albumin level, pro-13 controls using single photon emission computed tothrombin time, indocyanine green retention rate at 15 minmography (SPECT) imaging with a radiolabeled asialoutes, indocyanine green disappearance rate, and Pugh modiglycoprotein analog, Technetium-99m-diethylenetrified-Child-Turcotte criteria score (CTCS). aminepentaacetic acid-galactosyl-human serumThe purpose of this study was to document changes in the albumin (Tc-99m GSA). Counts of Tc-99m GSA radioachepatic functional reserve of the right and left hepatic lobes tivity in the liver on SPECT images significantly correwith the progression of chronic liver disease, using computed lated (P õ .0001) with the serum albumin level (r Å tomography (CT) and Tc-99m GSA single photon emission .612), log (serum cholinesterase activity) (r Å .618), secomputed tomography (SPECT), and to determine whether rum bilirubin level (r Å .628), prothrombin time (r Å changes in imaging modalities reflect the hepatic morphologi-.715), hepaplastin test (r Å .637), and indocyanine cal changes in cirrhosis. Å .491, P Å .0019) significantly. These findings suggest All controls were normal on physical examination and results of liver that the reduction of hepatic functional reserve per function tests, including alanine transaminase, aspartate transamiunit hepatic volume and numerical density of the he-nase, bilirubin, and alkaline phosphatase were normal. The subjects patocytes, and the proliferation of fibrosis in patients included 13 controls (7 men and 6 women; average age, 59 years; with chronic liver disease is slower in the left lobe than range, 36 to 76 years) and 28 patients with chronic liver disease.The patients with chronic liver disease were diagnosed on the basis of in the right. We discuss a possible biological basis for physical findings, ultrasound findings, CT findings, and biochemical these apparent lobar differences and for hepatic mor- 1997;25:828-832.)Of the 28 patients with chronic liver disease, 5 were caused by alcohol and 23 were caused by viral hepatitis. Because hepatic morphological Previous studies have documented a relative reduction in changes in cirrhosis are not pathognomonic for a specific cause, 4 all of the patients with chronic liver disease underwent a full evaluation. the size of the right hepatic lobe with enlargement of the Before the Tc-99m GSA imaging, subjects underwent conventional left hepatic lobe in patients with cirrhosis. in each lobe, 5,6 it remains unclear how these measures change The severity of liver disease was quantified by the Pugh modifiedin each lobe in cirrhosis, or how they correlate with typical Child-Turcotte criteria.14 Of the 28 patients with chronic liver dismorphological changes ...

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Section: Aid Hepa 0025mentioning

confidence: 99%

Hepatic lobar differences in progression of chronic liver disease: Correlation of asialoglycoprotein scintigraphy and hepatic functional reserve

et al. 1997

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“…Recently sonographic angiography with intraarterial carbon dioxide enhancement has been demonstrated to be highly sensitive and specific for FNH [8,11]. Since color Doppler sonography provides information about the vascular pattern of tumors, it is a noninvasive means of obtaining information that is otherwise obtainable only with angiography [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Hepatic focal nodular hyperplasia: findings on color Doppler ultrasound

Wang

Lin

et al. 1997

Abdom Imaging

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“…At the present, as regards FNH, a color Doppler signal pattern appears to be more specific in its diagnosis [11,12].…”

Section: Discussionmentioning

confidence: 99%

“…More recently, Tanaka et al [10] reported that the characteristic Doppler pattern of HCC is a pulsatile afferent flow signal with constant efferent flow, and with this finding, differentiation between HCC and adenomatous hyperplastic nodule will be possible. Similarly, as regards FNH, Kudo et al [11] reported that this nodule has a characteristic Doppler signal pattern, i.e. centrifugal pulsatile flow signals originating from the central zone.…”

Section: Discussionmentioning

confidence: 99%

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Differentiation of Hepatic Tumors by Color Doppler Imaging: Role of the Maximum Velocity and the Pulsatility Index of the Intratumoral Blood Flow Signal

Kudo

Tochio²,

Zhou³

2004

Intervirology

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Doppler spectral analysis using color Doppler ultrasonography (US) was performed in a total of 133 patients with 135 hepatic tumors, including 88 hepatocellular carcinomas (HCCs), 30 metastatic hepatic cancers, 15 hemangiomas and 2 focal nodular hyperplasias (FNHs). Mean ± SD of maximum velocity (Vmax) in hemangiomas (15.0 ± 16.0 cm/s) was significantly lower than in HCCs (34.9 ± 26.7 cm/s) and in metastases (37.9 ± 17.4 cm/s). Mean ± SD of the pulsatility index (PI) in hemangiomas (0.45 ± 0.41) was significantly lower than in HCCs (1.52 ± 0.71) and metastases (1.44 ± 0.43). Mean ± SD of Vmax and PI in FNH was 20.0 ± 11.3 cm/s and 0.90 ± 0.35, respectively. HCC showed a wide spectrum in terms of Vmax and PI; however, 18% of the HCC nodules had relatively high PI (>2.0). Specificity of Vmax more than >60 cm/s and PI more than 2.0 for the diagnosis of HCC were 92 and 94%, respectively. On the other hand, 87% of hemangiomas showed relatively lower Vmax (<30 cm/s) and 87% of hemangiomas showed relatively low PI (<1.0 cm/s). Specificity of Vmax less than 30 cm/s and PI less than 1.0 for the diagnosis of hemangioma were 47 and 78%, respectively. When taking account of both parameters, Vmax and PI, diagnostic efficacy for hemangioma and HCC was greatly improved (sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 80, 86, 85, 41 and 97%, respectively, in hemangioma, and 38, 85, 54, 83 and 58%, respectively, in HCC) as compared with the results with Vmax or PI alone. In conclusion, in addition to the information obtained by Vmax, simultaneous measurement of PI adds valuable information useful in the noninvasive differentiation among hepatic tumors by Doppler spectral analysis at color Doppler US.

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Color Doppler flow imaging of hepatic focal nodular hyperplasia

Cited by 15 publications

References 4 publications

Hepatic lobar differences in progression of chronic liver disease: Correlation of asialoglycoprotein scintigraphy and hepatic functional reserve

Hepatic lobar differences in progression of chronic liver disease: Correlation of asialoglycoprotein scintigraphy and hepatic functional reserve

Hepatic focal nodular hyperplasia: findings on color Doppler ultrasound

Differentiation of Hepatic Tumors by Color Doppler Imaging: Role of the Maximum Velocity and the Pulsatility Index of the Intratumoral Blood Flow Signal

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