Color Doppler Imaging in Patients With Asymmetric Glaucoma and Unilateral Visual Field Loss

Nicolela, Marcelo T.; Drance, Stephen M.; Rankin, Simon J. A.; Buckley, Anne; Walman, Brenda E.

doi:10.1016/s0002-9394(14)75424-8

Cited by 133 publications

(101 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These data confirm previous haemodynamic studies performed on patients with OH who showed a reduction in blood flow in the temporal quadrants 50,51 and in the inferior quadrant of the optic nerve. 52,53 Thus, in the case of OH, the statistical correlation test suggested that anatomical and functional impairment is not related to the increase of the IOP but to ischemic damage at the surface nerve fibre layer, but above all at a laminar and retrolaminar level of the optic nerve.…”

Section: Discussionsupporting

confidence: 91%

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Cellini

Bernabini

Carbonelli

et al. 2006

Eye

View full text Add to dashboard Cite

Purpose To study in ocular hypertension (OH) the retinal nerve fibre layer (RNFL) with optical coherence tomography (OCT) and the neuronal function with frequency-doubling technology (FDT) to assess which of the two methods was more sensitive in detecting early glaucomatous damage. Furthermore, a colour Doppler imaging (CDI) of the optic nerve was carried out to highlight any correlation with RNFL thickness and FDT abnormality. Materials and methods We enrolled 28 ocular hypertensive patients who underwent OCT of the RNFL and FDT. Moreover, we performed a CDI of the ophthalmic artery (OA), central retinal artery (CRA), and posterior ciliary arteries (PCAs). Results The patients with OH following OCT revealed a significant thinning in the RNFL as compared to the control group only in the inferior quadrant: 122.250714.091 vs 131.750710.729 lm (Po0.045). As regards FDT, there was a significant difference between the two groups only for pattern standard deviation (PSD): 3.87371.488 vs 1.93870.704 dB (Po0.044). In OH and in the control group, CDI resistance index (RI) in the OA was 0.76870.012 vs 0.74570.019 (Po0.022), in the CRA was 0.6670.012 vs 0.64570.019 (Po0.032), and in PCAs was 0.67370.039 vs 0.62270.012 (Po0.037). The OCT had a sensitivity of 83% but only in the inferior RNFL quadrant. The FDT-PSD revealed a sensitivity of 85%. Conclusions Both FDT and OCT detect early glaucomatous damage with a slightly superior sensitivity of FDT vs OCT. The CDI measurements suggest that circulatory abnormalities may have a role in the development of OCT and FDT damage.

show abstract

Section: Discussionsupporting

confidence: 91%

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Cellini

Bernabini

Carbonelli

et al. 2006

Eye

View full text Add to dashboard Cite

show abstract

“…15 Although secondary reduction of ocular blood flow can be observed in glaucoma, there is a component of ocular blood flow reduction that is independent of optic nerve damage and intraocular pressure. 16,17 In addition, upregulation of the hypoxia-inducible factor 1-␣ was observed in the optic nerve head of patients with glaucoma. 18 It was also shown that the reduced blood flow was not limited to the eye.…”

Section: Ho Et Al Open-angle Glaucoma and Strokementioning

confidence: 99%

Open-Angle Glaucoma and the Risk of Stroke Development

Lin

2009

Stroke

View full text Add to dashboard Cite

Background and Purpose-Although open-angle glaucoma (OAG) is associated with some of the risk factors of stroke development, there is still no published study addressing whether OAG increases the risk of stroke development. We investigated the risk of stroke development after a diagnosis of OAG. Methods-Data were retrospectively collected from the Taiwan National Health Insurance Research Database, which is comprised of 1 073 891 random subjects from among Taiwan's 23 million residents. The study cohort comprised all patients with a diagnosis of OAG (International Classification of Diseases, 9th Revision, Clinical Modification code 365.1 to 365.11) in 2001 (nϭ4032). The comparison cohort was comprised of randomly selected patients (5 for every patient with OAG, nϭ20 160) matched with the study group in terms of age, gender, geographic location, and comorbid medical disorders. Patients were tracked from their index visits for 5 years. Cox proportional hazard regression was used to compute the 5-year stroke-free survival rate after adjusting for possible confounding factors. Results-Stroke developed in 14.9% of patients with OAG and 9.5% of patients in the comparison cohort during the 5-year follow-up period. Patients with OAG had significantly lower 5-year stroke-free survival rates than patients in the comparison cohort. After adjusting for patients' demographic characteristics and selected comorbidities, patients with OAG were found to have a 1.52-fold (95% CI, 1.40 to 1.72) higher risk of having a stroke than the matched comparison cohort. Conclusions-Patients

show abstract

“…However, the increased vascular resistance in the eye distal to the ophthalmic artery in normal-tension glaucoma patients (Harris et al, 1994) does not support the idea that the vascular change is ascribable to persistent ocular hypertension. The findings that even eyes with normal visual fields in patients with asymmetric glaucoma had decreased blood velocity in the retrobulbar vessels suggested that circulatory changes probably precede detectable glaucomatous damage and may therefore be involved in the pathogenesis of the disease in some patients (Nicolela et al, 1996).…”

Section: Impaired Ocular Circulation: Relation To Glaucomamentioning

confidence: 99%

The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels

2003

View full text Add to dashboard Cite

Color Doppler Imaging in Patients With Asymmetric Glaucoma and Unilateral Visual Field Loss

Cited by 133 publications

References 29 publications

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Open-Angle Glaucoma and the Risk of Stroke Development

The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels

Contact Info

Product

Resources

About