Color doppler imaging: Methodology and preliminary results in glaucoma

Sergott, Robert C.; Aburn, Neil S.; Trible, John R.; Lieb, Wolfgang E.; Flaharty, Patrick M.

doi:10.1016/0039-6257(94)90048-5

Cited by 45 publications

(26 citation statements)

References 16 publications

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“…(Table 3, 4). These results were consistent with previous reports on POAG Rankin et al 1995;Sergott et al 1994;Yamazaki & Hayamizu 1995). However, for patients with early glaucoma, we could only detect a significantly decreased PSV in nasal PCA as compared with normal subjects, implicating that hemodynamic alteration in glaucoma may occur earlier in the ciliary circulation than in the retinal circulation.…”

Section: Discussionsupporting

confidence: 93%

“…By means of CDI, decreased flow velocity and increased vascular resistance in the central retinal artery (CRA) and posterior ciliary arteries (PCA) have also been identified for patients with POAG and NTG (Butt et al 1995;Harris et al 1994;Rankin et al 1995;Sergott et al 1994;Yamazaki & Hayamizu 1995). In addition, either spontaneous or artificial elevation of intraocular pressure (IOP) was associated with decreased flow velocity and increased resistive index in the CRA and PCA (Harris et al 1996;Liu et al 1997;Trible & Anderson 1998).…”

mentioning

confidence: 99%

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Variations in ocular hemodynamics in patients with early and late glaucoma

Liu

Chiou

Chiang

et al. 1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To determine the retrobulbar hemodynamics in glaucoma patients with different degrees of optic nerve damage. Methods: Color Doppler imaging was performed in 52 patients with controlled primary open angle glaucoma (POAG) and in 25 control subjects. Glaucomatous eyes were divided into early and late groups based on the perimetry findings. Peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index of the central retinal artery (CRA) and posterior ciliary arteries (PCA) were evaluated. Results: Early glaucoma showed significantly decreased PSV in nasal PCA when compared with the normal. Late glaucoma showed significantly decreased PSV and EDV in the CRA and nasal PCA, and significantly decreased PSV in temporal PCA as compared with the control and early glaucoma. The resistive index of the CRA also increased significantly in late glaucoma. Conclusion: Eyes with advanced glaucomatous optic neuropathy were associated with more marked alterations in retrobulbar circulation than eyes with less nerve damage.

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Variations in ocular hemodynamics in patients with early and late glaucoma

Liu

Chiou

Chiang

et al. 1999

Acta Ophthalmologica Scandinavica

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“…55 Nevertheless, at constant perfusion pressure and blood viscosity, increased fl ow velocities are associated with increased blood fl ow (in volume per time unit). 56 Our second limitation results from the use of a singular ocular imaging technology to study ocular blood perfusion, without providing data on the retina or other vascular beds.…”

Section: Discussionmentioning

confidence: 99%

A Comparison of the Long-Term Effects of Dorzolamide 2% and Brinzolamide 1%, Each Added to Timolol 0.5%, on Retrobulbar Hemodynamics and Intraocular Pressure in Open-Angle Glaucoma Patients

Martínez

Sánchez-Salorio²

2009

Journal of Ocular Pharmacology and Therapeutics

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Purpose: To compare the effect on the retrobulbar hemodynamics and intraocular pressure (IOP) of dorzolamide 2% and brinzolamide 1%, each added to timolol 0.5% in patients with primary open-angle glaucoma (POAG). Methods: 146 POAG patients were prospectively randomized to receive either dorzolamide 2% or brinzolamide 1% BID, each added to timolol 0.5%, during a 60-month evaluator-masked study. At baseline and every 6 months for 60 months, we measured the retrobulbar hemodynamic parameters in the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (SPCA) using color Doppler imaging (CDI), intraocular pressure (IOP), and blood pressure measurements. Results: Dorzolamide signifi cantly increased the end-diastolic velocity (EDV) in the OA in 1.22 cm/s, 95% confi dence interval (95% CI) 0.90-1.56 cm/s, P < 0.001 and reduced the resistivity index (RI) in the OA in 0.04 units, 95% CI 0.03-0.05, P < 0.001. None of the retrobulbar parameters changed signifi cantly on therapy with brinzolamide when the results were analyzed at month 60. Both dorzolamide and brinzolamide signifi cantly decreased IOP (-4.3, 95% CI -4.5 to -4.2 mmHg and -4.3, 95% CI -4.4 to -4.2 mmHg, respectively). Dorzolamide significantly reduced the RI in the OA from 0.74 (0.02) to 0.70 (0.02), CRA from 0.66 (0.02) to 0.62 (0.02), and SPCA from 0.66 (0.02) to 0.62 (0.02), P < 0.001, respectively. Conclusions: Our results suggest augmented retrobulbar blood fl ow after 5 years of treatment with dorzolamide but not with brinzolamide, each added to timolol, in POAG patients.

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“…18 Nevertheless, studies of retrobulbar blood velocities in POAG and NTG patients have found increased resistance to blood flow and reduced blood flow velocities. 86,[119][120][121][122] It has also been suggested that the existence of reduced retrobulbar hemodynamics in glaucoma patients may be associated with poor disease prognosis. 123 In a 7-year follow-up of POAG patients, increased resistive index in the ophthalmic artery was associated with an approximately sixfold increase in the likelihood of visual field deterioration compared with a cohort of POAG patients with a lower resistive index and stable fields.…”

Section: Color Doppler Ultrasound Imagingmentioning

confidence: 99%