Color Doppler Misoprostol Response Study (CDMRS): An Evaluation Tool for Patients Awaiting Myomectomy

Hasan, Musarrat; Nasir, Ayesha; Saba, Erum

doi:10.1016/j.jmu.2014.05.001

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Another study by [9] included 20 women with uterine fibroid underwent laparoscopic myomectomy and UAL with a ligating clip followed by myomectomy and removal of clips showed that intra operative blood loss in UAL group was statistically significant less than the control group. Some studies had reported that the preoperative use of misoprostol before laparoscopic myomectomy had significant reduction of intraoperative blood loss as [10,11,12]. Stated that preoperative insertion of 800 mg of misoprostol rectally showed significant reduction in the blood flow of the segmental branch of the uterine artery and those supplying fibroids and so significant reduction in intraoperative blood loss [11].…”

Section: Journal Of Gynecology and Women's Healthmentioning

confidence: 99%

Reduction of Blood Loss During Laparoscopic Myomectomy: Uterine Artery Ligation Versus Intra-Vaginal Misoprostol

Nofal¹

2019

JGWH

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Objectives: This study was designed to compare laparoscopic uterine artery ligation and vaginal misoprostol in reducing intra-operative blood loss during laparoscopic myomectomy and verifies the effect of uterine artery ligation by different methods upon intra-and post-operative complications of laparoscopic myomectomy.Background: laparoscopic myomectomy is a challenging surgical procedure for gynecologists. Material and Methods: The study was prospective clinical randomized trial, where 50 women with symptomatic fibroids managed with laparoscopic myomectomy with either bilateral uterine artery ligation or pre-operative misoprostol, outcome parameters in both groups were operative time, blood loss during surgery, fluid management data and post-operative period. Statistical presentation and analysis of the present study was conducted with SPSS V.20Results: a total of 50 patients of these 30 patients underwent laparoscopic myomectomy and bilateral uterine artery ligation and 20 underwent laparoscopic myomectomy after preoperative vaginal misoprostol the mean intra operative blood loss was 522.5+136.6 versus 193.8+78.7 in misoprostol versus UAL groups and there was a highly significant difference between the two groups as regarding blood loss (less in UAL group), also there was significant as regarding operative time (longer in UAL group).There was no significant difference as regarding intraoperative complications and post-operative period. Conclusion:Bilateral ligation of uterine artery has a more powerful effect than preoperative single dose of misoprostol in reducing blood loss during laparoscopic myomectomy, but bilateral ligation of uterine artery takes a longer time however no significant difference between them as regarding post-operative complications.

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Section: Journal Of Gynecology and Women's Healthmentioning

confidence: 99%

Reduction of Blood Loss During Laparoscopic Myomectomy: Uterine Artery Ligation Versus Intra-Vaginal Misoprostol

Nofal¹

2019

JGWH

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Preoperative medical therapy before surgery for uterine fibroids

Lethaby

Puşcaşiu

Vollenhoven

2017

Cochrane Database of Systematic Reviews

107

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Background Uterine fibroids occur in up to 40% of women aged over 35 years. Some are asymptomatic, but up to 50% cause symptoms that warrant therapy. Symptoms include anaemia caused by heavy menstrual bleeding, pelvic pain, dysmenorrhoea, infertility and low quality of life. Surgery is the first choice of treatment. In recent years, medical therapies have been used before surgery to improve intraoperative and postoperative outcomes. However, such therapies tend to be expensive. Fibroid growth is stimulated by oestrogen. Gonadotropin-hormone releasing analogues (GnRHa) induce a state of hypo-oestrogenism that shrinks fibroids , but has unacceptable side effects if used long-term. Other potential hormonal treatments, include progestins and selective progesterone-receptor modulators (SPRMs). This is an update of a Cochrane Review published in 2000 and 2001; the scope has been broadened to include all preoperative medical treatments. Objectives To assess the effectiveness and safety of medical treatments prior to surgery for uterine fibroids. Search methods We searched the Cochrane Gynaecology and Fertility Group specialised register, CENTRAL, MEDLINE, Embase, PsycINFO and CINAHL in June 2017. We also searched trials registers (ClinicalTrials.com; WHO ICTRP), theses and dissertations and the grey literature, handsearched reference lists of retrieved articles and contacted pharmaceutical companies for additional trials. Selection criteria We included randomised comparisons of medical therapy versus placebo, no treatment, or other medical therapy before surgery, myomectomy, hysterectomy or endometrial resection, for uterine fibroids. Data collection and analysis We used standard methodological procedures expected by The Cochrane Collaboration.

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Color Doppler Misoprostol Response Study (CDMRS): An Evaluation Tool for Patients Awaiting Myomectomy

Cited by 2 publications

References 22 publications

Reduction of Blood Loss During Laparoscopic Myomectomy: Uterine Artery Ligation Versus Intra-Vaginal Misoprostol

Reduction of Blood Loss During Laparoscopic Myomectomy: Uterine Artery Ligation Versus Intra-Vaginal Misoprostol

Preoperative medical therapy before surgery for uterine fibroids

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