“…The immediate therapeutic effect has been measured by a change of blood flow after TACE and after local ablation therapy (i.e., PEIT, RFA); and the complete absence of vascularity in the treated region shown by contrast-enhanced computed tomography (CT) or Doppler sonography, can promise the long-term local control of the lesions. [15][16][17] However, in proton-treated HCCs, it is not easy to evaluate the effect of proton radiotherapy properly because the tumor stain tends to be sustained for a longer period of time. Therefore, a novel methodology for the determination of the clinical efficacy of proton radiotherapy needs to be established.…”