This study demonstrates that when vascular resistance is low, peak systolic velocity and peak flow volume increase with increasing blood pressure. We used ischemia with reactive hyperemia to create reproducible low resistance conditions in 32 volunteers. Ischemia resulted in sharp increases in systolic and diastolic velocities, while the difference between these velocities increased minimally. Spontaneous variations in subject's systolic blood pressure were positively correlated with peak sys-R ecent reports have shown excellent results in distinguishing malignant from benign ovarian masses by high Doppler shift frequencies and low Doppler index values (RI, PI).t· 3 In other studies, malignant and benign lesions have shown overlap of these measurements.4. . . ' 5 We speculated that systemic BP might be an uncontrolled variable in study populations, accounting for some of the observed inconsistency. To evaluate the potential effect of BP, we used a low resistance is- We conclude that low resistance flow is blood pressure dependent. Because blood pressure increases with age, tumor velocity and frequency shift thresholds may need blood pressure correction if applied over wide age ranges. The resistive index was independent of blood pressure and thus may be preferable. KEY WORDS: Doppler ultrasonography; Blood flow; Blood pressure; Neoplasm. chemic model in normal volunteers to simulate low resistance tumor flow. Under these conditions, we characterized the relationship between spontaneous variations in systemic BP found among our subjects and the corresponding variations in Doppler sonographic measurements of velocity, flow volume, and Rl.
SUBJECTS AND METHODSWe studied 32 volunteers (21 male and 11 female) between the ages of 24 and 53 years. None had a history of heart disease, anemia, or use of vasoactive drugs.The subjects were examined while resting supine. The systemic BP was estimated by auscultation of systolic and diastolic Korotkoff's sounds in the brachial artery below a blood pressure cuff on the right upper arm.For the study of Doppler flow during reactive hyperemia, the BP cuff was placed on "the upper right forearm of the subject. A transverse gray scale sonographic image 10 em above the elbow was used to