Color Duplex Sonography vs. Computed Tomography: Accuracy in the Preoperative Evaluation of Renal Cell Carcinoma

Spahn, Martin; Portillo, F. J. Martínez; Michel, Maurice Stephan; Siegsmund, M.; Gaa, Jochen; Alken, P.; Jünemann, Klaus-Peter

doi:10.1159/000049796

Cited by 17 publications

(10 citation statements)

References 19 publications

(25 reference statements)

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“…Early publications reported a staging accuracy of US inferior to that of spiral CT [29] . Conversely, other authors concluded that duplex Doppler US was at least as accurate as CT scanning in the staging of RCC [30,31] .…”

Section: Stagingmentioning

confidence: 99%

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Imaging of Renal Cell Carcinoma: State of the Art and Recent Advances

Sacco¹,

Pinto²,

Totaro³

et al. 2010

Urol Int

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Background and Aim: Renal cell carcinoma (RCC) is the 13th most common cancer worldwide and accounts for 4% of all adult malignancies. Herein the state of the art and recent advances in cross-sectional radiological imaging applied to RCC are reviewed, including ultrasonography, computed tomography, magnetic resonance imaging, and positron emission tomography. Methods: Literature search of peer-reviewed papers published by October 2010. Results: In front of more conventional and widespread imaging tools, such as ultrasonography and computed tomography, an array of newer and attractive radiological modalities are under investigation and show promise to improve our ability to noninvasively detect renal tumors and its recurrences, accurately assess the extent of the disease, and reliably evaluate treatment response, particularly in the era of antiangiogenetic therapy. Conclusions: Recent major advances in radiological imaging techniques have considerably improved our ability to diagnose, stage and follow-up RCC. Further studies are needed to evaluate the potential of most recent and still investigational imaging tools.

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Section: Stagingmentioning

confidence: 99%

“…Many authors reported that the overall accuracy of Doppler US was higher than, or at least similar to CT scan or MRI in detecting tumor extension into renal veins and IVC [30,31,[35][36][37] . However, the sensitivity of this diagnostic tool seems depending on the position of the thrombus.…”

Section: Stagingmentioning

confidence: 99%

Imaging of Renal Cell Carcinoma: State of the Art and Recent Advances

Sacco¹,

Pinto²,

Totaro³

et al. 2010

Urol Int

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show abstract

“…1, 2). Much of the radiology literature regarding RCC imaging is devoted to two main topics: (a) differentiating RCC from benign renal lesions (e.g., cysts and angiomyelolipomas) and (b) local staging of suspected RCC for surgical management (3)(4)(5)(6)(7). With the explosion of the use of cross-sectional imaging throughout medicine, the diagnostic radiologist is frequently required to determine whether an incidental renal lesion is likely malignant.…”

Section: Traditional Imaging Of Renal Cell Carcinomamentioning

confidence: 99%

Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Assessing Tumor Vascularity and Vascular Effects of Targeted Therapies in Renal Cell Carcinoma

Rosen

Schnall

2007

Clinical Cancer Research

123

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Traditional cross-sectional tumor imaging focuses solely on tumor morphology.With the introduction of targeted biological therapies in human trials, morphologic change may lag behind other physiologic measures of response on clinical images. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a new imaging method for assessing the physiologic state of tumor vascularity in vivo. DCE-MRI, which uses available imaging techniques and contrast agents, assays the kinetics of tumor enhancement during bolus i.v. contrast administration. Modeling of the temporal enhancement pattern yields physiologic variables related to tumor blood flow and microvessel permeability. Changes in these variables after vascular-targeted therapy can then be quantified to evaluate the tumor vascular response. As these responses may precede morphologic tumor shrinkage, DCE-MRI might serve as a noninvasive means of monitoring early tumor response to vascular-targeted therapy. Renal cell carcinoma provides an excellent model for assessing the effect on DCE-MRI in clinical trials. The vascular richness of renal tumors provides a large dynamic scale of DCE-MRI measures. Patients with disseminated renal cell carcinoma frequently present with one or several large tumors, creating an easy imaging target for DCE-MRI evaluation. Finally, renal cell carcinoma is clearly susceptible to therapies that target tumor angiogenesis. DCE-MRI can be used to monitor the vascular changes induced by such therapies. Future efforts must be directed to standardizing image acquisition and analysis techniques to quantify tumor vascular responses. Traditional Imaging of Renal Cell CarcinomaCross-sectional imaging, including ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI), plays a dominant role in the imaging of renal cell carcinoma (RCC; refs. 1, 2). Much of the radiology literature regarding RCC imaging is devoted to two main topics: (a) differentiating RCC from benign renal lesions (e.g., cysts and angiomyelolipomas) and (b) local staging of suspected RCC for surgical management (3-7). With the explosion of the use of cross-sectional imaging throughout medicine, the diagnostic radiologist is frequently required to determine whether an incidental renal lesion is likely malignant. Criteria for these determinations are multifaceted, depending on the imaging modality. For example, CT imaging of the renal lesion before and after iodinated i.v. contrast allows for the delineation of solid (i.e., enhancing) lesions from nonenhancing cysts (8). When a primary renal lesion is shown to be solid, local staging by imaging is used to direct medical or surgical management. In the metastatic setting, cross-sectional imaging, usually CT, is again the preferred method for assessing disease progression and response to therapy. As is true for assessing metastatic response for other tumors, morphologic criteria (i.e., change in unidimensional or bidimensional diameters) are most commonly used (9). Imaging ''Phenotypes'' in RCCGiven th...

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“…Bestätigt werden diese Angaben durch Untersuchungen von Spahn et al [22]. In einer prospektiven Untersuchung bei 60 Patienten konnten die Autoren 15 Tumorthromben operativ nachweisen; 13 der 15 Tumorthromben wurden präoperativ mittels Duplexsonographie und 8 von 15 mittels Spiral-CT korrekt diagnostiziert.…”

Section: ᭤ Intravasale Ausbreitung Von Tumorzapfenunclassified

Bildgebende Diagnostik vor Nierentumoroperationen

Siemer

Uder

2002

Urologe [A]

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Color Duplex Sonography vs. Computed Tomography: Accuracy in the Preoperative Evaluation of Renal Cell Carcinoma

Cited by 17 publications

References 19 publications

Imaging of Renal Cell Carcinoma: State of the Art and Recent Advances

Imaging of Renal Cell Carcinoma: State of the Art and Recent Advances

Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Assessing Tumor Vascularity and Vascular Effects of Targeted Therapies in Renal Cell Carcinoma

Bildgebende Diagnostik vor Nierentumoroperationen

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