Color Representation Is Retinotopically Biased but Locally Intermingled in Mouse V1

Aihara, Shuhei; Yoshida, Takashi; Hashimoto, Takayuki; Ohki, Kenichi

doi:10.3389/fncir.2017.00022

Cited by 18 publications

(22 citation statements)

References 49 publications

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“…By projecting 29 the spatial profile of cones into visuotopic coordinates based on the mean eye position during our experiments (Figure 1 – figure supplement 1), we computed expected middle/short ratios for each of the elevations we tested (Figure 3 – figure supplement 1). Similar to the estimated relative opsin weights across V1 under photopic conditions 23,37 , 2.3, 0.81, 0.81, the cone functional distribution predicts 2.3, 1.0, and 0.44 at –10°, 10°, and 30°, respectively; both predict far less middle-band sensitivity that we observed. This result suggests that rod opsin sensitivity contributes significantly to mouse perceptual sensitivity at these light levels, at least as much as 60% (Figure 3 – figure supplement 1) at higher elevations.…”

Section: Resultssupporting

confidence: 75%

Mouse hue and wavelength-specific luminance contrast sensitivity are non-uniform across visual space

Denman

Luviano

Ollerenshaw

et al. 2017

Preprint

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9Mammalian visual behaviors, as well as responses in the neural systems thought to underlie these 10 behaviors, are driven by luminance and hue contrast. With tools for measuring activity in cell-type 11 specific populations in the mouse during visual behavior gaining traction, it is important to define the 12 extent of luminance and hue information that is behaviorally-accessible to the mouse. A non-uniform 13 distribution of cone opsins in the mouse potentially complicates both luminance and hue sensitivity: 14 opposing gradients of short (UV-shifted) and middle (blue/green) cone opsins suggest that hue 15 discrimination and wavelength-specific luminance contrast sensitivity may differ depending on 16 retinotopic location. Here we ask if, and how well, mice can discriminate color and wavelength-specific 17 luminance across visuotopic space. We found that mice were able to discriminate hue, and were able 18 to do so more broadly across visuotopic space than expected from the cone-opsin distribution. We also 19 found wavelength-band specific differences in luminance sensitivity. 20 21 peer-reviewed)

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Section: Resultssupporting

confidence: 75%

Mouse hue and wavelength-specific luminance contrast sensitivity are non-uniform across visual space

Denman

Luviano

Ollerenshaw

et al. 2017

Preprint

View full text Add to dashboard Cite

show abstract

“…Several recent studies have found similar mesoscale organization in other response properties in mouse visual cortex. For example, recent studies have found retinotopic asymmetry of color selectivity within area V1 61 and binocular disparity preference within area RL 52 . Moreover, researchers also found that neurons in higher visual and parietal regions exhibit anatomical gradients of task-modulated responses during navigation in a virtual environment, and that these gradients cross retinotopic borders 62 .…”

Section: Discussionmentioning

confidence: 99%

Distributed and retinotopically asymmetric processing of coherent motion in mouse visual cortex

Sit

Goard

2020

Nat Commun

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Perception of visual motion is important for a range of ethological behaviors in mammals. In primates, specific visual cortical regions are specialized for processing of coherent visual motion. However, whether mouse visual cortex has a similar organization remains unclear, despite powerful genetic tools available for measuring population neural activity. Here, we use widefield and 2-photon calcium imaging of transgenic mice to measure mesoscale and cellular responses to coherent motion. Imaging of primary visual cortex (V1) and higher visual areas (HVAs) during presentation of natural movies and random dot kinematograms (RDKs) reveals varied responsiveness to coherent motion, with stronger responses in dorsal stream areas compared to ventral stream areas. Moreover, there is considerable anisotropy within visual areas, such that neurons representing the lower visual field are more responsive to coherent motion. These results indicate that processing of visual motion in mouse cortex is distributed heterogeneously both across and within visual areas.

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“…For example, recent studies have found retinotopic asymmetry of color selectivity within area V1 [61] and binocular disparity preference within area RL [52]. Moreover, researchers also found that neurons in higher visual and parietal regions exhibit anatomical gradients of task-modulated responses during navigation in a virtual environment, and that these gradients cross retinotopic borders [62].…”

Section: Implications For Organizational Principles Of Cortical Procementioning

confidence: 97%

Distributed and Retinotopically Asymmetric Processing of Coherent Motion in Mouse Visual Cortex

Sit¹,

Goard²

2019

Preprint

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Perception of visual motion is important for a range of ethological behaviors in mammals. In primates, specific higher visual cortical regions are specialized for processing of coherent visual motion. However, the distribution of motion processing among visual cortical areas in mice is unclear, despite the powerful genetic tools available for measuring population neural activity.Here, we used widefield and 2-photon calcium imaging of transgenic mice expressing a calcium indicator in excitatory neurons to measure mesoscale and cellular responses to coherent motion across the visual cortex. Imaging of primary visual cortex (V1) and several higher visual areas (HVAs) during presentation of natural movies and random dot kinematograms (RDKs) revealed heterogeneous responses to coherent motion. Although coherent motion responses were observed throughout visual cortex, particular HVAs in the putative dorsal stream (PM, AL, AM) exhibited stronger responses than ventral stream areas (LM and LI). Moreover, beyond the differences between visual areas, there was considerable heterogeneity within each visual area.Individual visual areas exhibited an asymmetry across the vertical retinotopic axis (visual elevation), such that neurons representing the inferior visual field exhibited greater responses to coherent motion. These results indicate that processing of visual motion in mouse cortex is distributed unevenly across visual areas and exhibits a spatial bias within areas, potentially to support processing of optic flow during spatial navigation.

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Color Representation Is Retinotopically Biased but Locally Intermingled in Mouse V1

Cited by 18 publications

References 49 publications

Mouse hue and wavelength-specific luminance contrast sensitivity are non-uniform across visual space

Mouse hue and wavelength-specific luminance contrast sensitivity are non-uniform across visual space

Distributed and retinotopically asymmetric processing of coherent motion in mouse visual cortex

Distributed and Retinotopically Asymmetric Processing of Coherent Motion in Mouse Visual Cortex

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