Colorectal adenocarcinoma metastasizing to the oral mucosa of the upper jaw

Baranović, Marijan; Vidaković, Bruno; Sauerborn, Damir; Perić, Berislav; Uljanić, Ivana; Mahovne, Ivana

doi:10.2298/sarh1506314b

Cited by 8 publications

(7 citation statements)

References 11 publications

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“…Oral cavity metastasis usually occur with other sites of metastasis and prognosis is very bad [3,[6][7][8][9][10][11]. In the present case, the lesion progressed over two weeks and patient developed cheek swelling, pain, bleeding and difficulty in mastication.…”

Section: Discussionmentioning

confidence: 58%

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Maxillary Gingival Metastasis from Adenocarcinoma Colon

Nair¹,

Mathews²,

Aparna³

et al. 2021

JCR

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Background: Oral cavity metastasis from colorectal cancers is rare. Among these gingival metastases are extremely rare. Few cases of metastasis to mandibular gingiva have been reported. Here we report a rare case of maxillary gingival metastasis from adenocarcinoma colon. Case Report: A fifty-year-old gentleman underwent emergency laparotomy and sigmoid resection for obstructive growth in sigmoid colon and was diagnosed as adenocarcinoma colon, pT4N1. He received twelve cycles of adjuvant chemotherapy. After a disease-free interval of four years, he developed multiple visceral metastases along with an ulcero-proliferative lesion in maxillary gingiva, biopsy from which was reported as adenocarcinoma metastasis from carcinoma colon. He received palliative radiotherapy to the gingival lesion and is on systemic chemotherapy for disseminated disease. Conclusion: Gingiva being a rare metastatic site, a biopsy is warranted to differentiate it from second primary malignancies of oral cavity..

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Section: Discussionmentioning

confidence: 58%

“…Oral cavity metastasis from colorectal cancers are rare. Most of the metastatic lesions occur in jaw bones [2], but cases of gingival metastasis also have been reported [3][4][5][6][7][8][9][10][11][12]. Most of the reported cases of gingival metastases are from mandibular gingiva.…”

Section: Introductionmentioning

confidence: 99%

Maxillary Gingival Metastasis from Adenocarcinoma Colon

Nair¹,

Mathews²,

Aparna³

et al. 2021

JCR

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“…However, Baranovic et al . ( 16 ) described a colorectal adenocarcinoma with metastases in the liver and oral cavity, but without affecting lungs or peritoneum, which are usually very common locations of metastases for this type of carcinomas. This can be explained by Batson's theory ( 16 ), which considers that there are 4 venous circuits: pulmonary, cava, portal and vertebral.…”

Section: Discussionmentioning

confidence: 99%

“…( 16 ) described a colorectal adenocarcinoma with metastases in the liver and oral cavity, but without affecting lungs or peritoneum, which are usually very common locations of metastases for this type of carcinomas. This can be explained by Batson's theory ( 16 ), which considers that there are 4 venous circuits: pulmonary, cava, portal and vertebral. In colorectal adenocarcinoma case, hematogenous dissemination through the vertebral circuit could occur, avoiding the neck and lungs region, thus producing oral metastases ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

“…This can be explained by Batson's theory ( 16 ), which considers that there are 4 venous circuits: pulmonary, cava, portal and vertebral. In colorectal adenocarcinoma case, hematogenous dissemination through the vertebral circuit could occur, avoiding the neck and lungs region, thus producing oral metastases ( 16 ). It is considered that hard tissues metastases occur through hematogenous dissemination, being the mandible more frequently affected than the maxilla, probably due to the presence of terminal vascularization in the region and a greater presence of hematopoietic cells in the mandible, especially in the canines posterior region ( 8 , 21 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

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Incidence rate of metastases in the oral cavity: a review of all metastatic lesions in the oral cavity

Oliver-Puigdomènech¹,

González-Navarro²,

Polis-Yanes³

et al. 2021

Med Oral

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Background Metastases in the oral cavity are rare and account for only 1 to 3% of all malignant lesions in this area. The primary location from which most metastases have been described in the oral cavity in adult patients include lungs, breasts, kidneys and colon. Material and Methods A systematic search of the literature was carried out following the PRISMA statement in PubMed database. Clinical trials and case series published in the last 10 years [2010-2020] were eligible to be selected. The headings and keywords used in the searches were “cancer” AND “oral metastases”, “incidence” AND “oral metastases”, “oral metastases” AND “jaw bone”, “oral metastases” AND “soft tissue”. Results For the study of the incidence of metastases in the oral cavity, 9 reports of clinical trials and 7 retrospective studies of case series have been included in this article. The primary locations from which more metastases have been described in the oral cavity are lungs (30.6% or 183 cases), breasts (22.2% or 133 cases), liver (15.5% or 93 cases), prostate (9 % or 54 cases), thyroid glands (8.1% or 49 cases), kidneys (7.3% or 44 cases), skin (2.3% or 14 cases), soft tissues (2% or 12 cases), colon (2% or 12 cases) and gastrointestinal (0.6% or 4 cases). These metastases have a predilection for hard tissues. The clinical presentation of these lesions varies from painless granulomatous lesions to lytic areas in the jaws. Conclusions Although metastases in the oral cavity is an uncommon pathology, early diagnosis is needed so that in the event that it is the first manifestation, it allows the primary tumor to be diagnosed as soon as possible. Key words: Cancer, oral metastases, incidence, jaw bone, soft tissue.

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