Colorectal adenoma-carcinoma sequence.

Khosraviani, Kourosh

doi:10.1136/gut.39.2.342

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…Colorectal cancer is the fourth most frequent cancer and has a high mortality worldwide. Colorectal cancers, according to the adenoma–carcinoma sequence theory, arise primarily in a setting where a multistep carcinogenesis event progresses from colorectal adenoma with a low grade of dysplasia to high dysplasia and, finally, to carcinoma 1 . Thus, colorectal adenoma has been recognized as the main precancerous lesion for most colorectal cancers.…”

Section: Introductionmentioning

confidence: 99%

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Progressive cellular response in the lamina propria of the colorectal adenoma–carcinoma sequence

et al. 2009

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Section: Introductionmentioning

confidence: 99%

“…Thus, colorectal adenoma has been recognized as the main precancerous lesion for most colorectal cancers. Although many molecular and genetic alterations involved in this sequence have been identified, 1 the exact mechanisms of the adenoma–carcinoma transition are still not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Progressive cellular response in the lamina propria of the colorectal adenoma–carcinoma sequence

et al. 2009

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“…According to the adenoma-carcinoma sequence hypothesis, most sporadic CRCs develop primarily from a pre-existing adenoma in a setting where a multistep molecular and histological carcinogenesis event progresses to a carcinoma (1,2). The transition from an adenoma to a CRC may take many years and can inevitably result in a series of changes that include altered cytokine secretion and immune cell function in the tumor microenvironment (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer

Cui

Gundersen

et al. 2014

Cancer Immunol Immunother

108

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Most sporadic colorectal cancers (CRCs) develop from preexisting adenomas. The transition from an adenoma to a CRC leads to disruption in cytokine secretion and immune imbalance.Interleukin-33 (IL-33) is a newly discovered proinflammatory cytokine belonging to the IL-1 cytokine family, and involved in the regulation of immune function and development of chronic colorectal inflammation and cancers. However, the activation of the IL33/ST2 axis alongside the colorectal adenoma-carcinoma sequence is poorly understood. Our aim is to evaluate the dynamics between the IL-33/ST2 axis and the human colorectal normaladenoma -carcinoma sequence. The expression of IL-33 in adenomas (n=50) determined by real-time PCR was significantly higher than that in the colorectal mucosa from normal individuals. The expression of IL-33 was also increased in CRCs (n=50) when compared to the normal control group. Significantly lower levels of IL-33 where found in the CRCs compared with the adenomas; moreover, the analysis revealed that a high IL-33 level was associated with a low dysplasia degree in the adenomas, as well as with a statistically nonsignificant increase of survival time in the CRC patients. The increased expression of IL-33 in adenomas/CRCs was confirmed by immunohistochemistry (IHC) which showed that IL-33 immunoreactivity was expressed in the adenomatous/cancerous epithelium, whereas it was undetectable in the normal controls. IHC also confirmed that the IL-33 receptor (ST2) is increased in tumor stromal cells. Double IHCs identified that IL-33 immunoreactivity was in the tumor stromal myofibroblasts and microvessels. In conclusion, the expression of IL-33 in the tumor microenvironment was dynamically altered along the colorectal adenomacarcinoma sequence; and may be a potential predictor for the progression of the adenoma to the CRC.3

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“…The important fundamental concept of colorectal cancer development is the "adenoma-carcinoma sequence." This is the carcinogenesis pathway of normal mucosa involving accumulation of genetic mutations and epigenetic changes, transformation to an adenomatous colorectal polyp, and eventually transformation to colorectal cancer, in a stepwise progression (28,29). Many studies have shown that endoscopic removal of colorectal polyps prevents colorectal cancer, and their results support the sequence pathway (30,31).…”

Section: Discussionmentioning

confidence: 95%

The Effects of Physical Activity and Body Fat Mass on Colorectal Polyp Recurrence in Patients with Previous Colorectal Cancer

Park

Kim

Lee

et al. 2017

Cancer Prevention Research

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We aimed to identify the effects of physical activity and body composition on colorectal polyp recurrence in patients with previous colorectal cancer. A total of 300 patients were selected randomly from the colorectal cancer survivor cohort of Severance Hospital (Seoul, Korea). Patients reported various recreational physical activities and received surveillance colonoscopy. Body composition was measured with a body composition analyzer. We compared patients who exercised for at least 1 hour/week (active) with those who exercised less frequently or not at all (sedentary). The active exercise group ( = 203) had a lower recurrence of advanced adenoma than the sedentary group ( = 97; 6.4% vs. 14.4%, = 0.023). The prevalence of advanced adenoma recurrence decreased in an exercise dose-dependent manner ( = 0.019). In multivariate logistic analysis, the independent factors associated with advanced polyp recurrence were body fat mass [OR, 7.601; 95% confidence interval (CI), 1.583-36.485; = 0.011] and active exercise (OR, 0.340; 95% CI, 0.143-0.809; = 0.015). In Cox proportional hazards models, body fat mass (HR, 5.315; 95% CI, 1.173-24.083; = 0.030) and active exercise (HR, 0.367; 95% CI, 0.162-0.833; = 0.017) were the independent factors associated with cumulative advanced adenoma recurrence. In conclusion, exercising for at least 1 hour/week and low body fat mass were found to be related to lower rates of colorectal polyp recurrence in the surveillance of colorectal cancer survivors. .

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Colorectal adenoma-carcinoma sequence.

Cited by 7 publications

References 5 publications

Progressive cellular response in the lamina propria of the colorectal adenoma–carcinoma sequence

Progressive cellular response in the lamina propria of the colorectal adenoma–carcinoma sequence

Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer

The Effects of Physical Activity and Body Fat Mass on Colorectal Polyp Recurrence in Patients with Previous Colorectal Cancer

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