Colorectal Adenoma Risk Is Increased among Recently Diagnosed Adult Celiac Disease Patients

Abstract

Background The association between celiac disease and colorectal neoplasia has been previously studied, but the question whether recently diagnosed celiac patients show an increased colorectal adenoma prevalence remains unanswered. Aims To compare the prevalence of colorectal adenomas between adult patients with a recent diagnosis of celiac disease versus healthy controls. Materials and Methods A retrospective case-control study was undertaken. Patients with a diagnosis of celiac disease at an age of 45 years or more who undertook colonoscopy six months before or six months after the initiation of a gluten-free diet were enrolled as cases. Asymptomatic subjects undertaking screening colonoscopy were recruited as controls in a 2 : 1 fashion. The prevalence of colorectal adenomas and the prevalence of advanced adenomas were compared between groups. Results 57 celiac disease patients and 118 controls were enrolled. There was a greater prevalence of female patients among the celiac group, with no significant differences in terms of age. There were more obese patients among controls and a higher proportion of tabaquism among celiac patients. Adenoma prevalence was significantly higher among celiac patients (47.37% versus 27.97%, p = 0.01). Advanced adenoma detection was not different between groups. Conclusion Adult patients with a recent diagnosis of celiac disease have an increased prevalence of colorectal adenomas.

Curcumin Resuscitate Gliadin Induced Oxidative Damage And Altered Cellular Responses In Human Intestinal Cells Via Cross-Talk Between The Transcription Factor Nrf-2 And Multifunctional Protein APE1

“…Gliadin protein triggers the antigenic response mainly by producing excess ROS, RNS, disturbing cellular antioxidant defence system and chronic in ammation in the human intestine, which ultimately leads to the autoimmunity (Perez et al 2017). In disease condition, the mucosa of the small intestine gets disrupted by autoantibodies and create avillus condition, which nally results in malabsorption, diarrhoea and hematochezia eventually resulting in colorectal cancer (Lasa et al 2018;Pasha et al 2016).…”

Current updates on the association between celiac disease and cancer, and the effects of the gluten‑free diet for modifying the risk (Review)

“…A previous study by Lasa et al (42) demonstrated that patients with cD have an increased risk of developing colorectal cancer. consistent gluten exposure in individuals with cD may increase their risk of developing colorectal neoplasia (42).…”

“…colorectal cancer is a cancer of the colon or rectum. It is the third most common type of cancer in males and the second most prevalent among females in the USA (42). The risk of developing colorectal cancer increase with age, diet and lifestyle.…”

“…Apart from age, a family history also contributes to an increased risk of this type of cancer. It begins with the loss of the adenomatous polyposis coli (APC) gene present on chromosome 5q21 and the subsequent activation of the KRAS oncogene and mutations in the TP53 gene (42,43).…”

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