Colorectal Cancer

Nicum, Shibani; Midgley, Rachel; Kerr, David J.

doi:10.1080/02841860310000412

Cited by 24 publications

(41 citation statements)

References 54 publications

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“…Seven patients were recruited into the surgical trial, and the remaining 24 into the radiological trial. 30 patients had liver metastases, the primary sites being colorectal (22), stomach (1), breast (1), lung (1), ovary (1), oesophagus (1) and pancreas (1) and adenocarcinoma of unknown primary (2). One patient had a primary HCC.…”

Section: Methodsmentioning

confidence: 99%

“…HIFU treatment is accurate, and intra-operative assessment of treatment provides an accurate measure of the zone of ablation and correlates well with MRI follow-up. Colorectal cancer is one of the leading causes of mortality in Europe and the USA [1]. Of those diagnosed with colorectal cancer, 20-30% will have metastases in the liver at the time of diagnosis, and overall 50% will develop liver metastases during the course of their disease [2,3].…”

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confidence: 99%

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High-intensity focused ultrasound treatment of liver tumours: post-treatment MRI correlates well with intra-operative estimates of treatment volume

Leslie

Ritchie²,

Illing³

et al. 2012

BJR

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Objectives: To assess the safety and feasibility of high-intensity focused ultrasound (HIFU) ablation of liver tumours and to determine whether post-operative MRI correlates with intra-operative imaging. Methods: 31 patients were recruited into two ethically approved clinical trials (median age 64; mean BMI 26 kg m 22). Patients with liver tumours (primary or metastatic) underwent a single HIFU treatment monitored using intra-operative Bmode ultrasound. Follow-up consisted of radiology and histology (surgical trial) or radiology alone (radiology trial). Radiological follow-up was digital subtraction contrast-enhanced MRI. Results: Treatment according to protocol was possible in 30 of 31 patients. One treatment was abandoned because of equipment failure. Transient pain and superficial skin burns were seen in 81% (25/31) and 39% (12/31) of patients, respectively. One moderate skin burn occurred. One patient died prior to radiological follow-up. Radiological evidence of ablation was seen in 93% (27/29) of patients. Ablation accuracy was good in 89% (24/27) of patients. In three patients the zone of ablation lay #2 mm outside the tumour. The median cross-sectional area (CSA) of the zone of ablation was 5.0 and 5.1 cm 2 using intra-operative and post-operative imaging, respectively. The mean MRI:B-mode CSA ratio was 1.57 [95% confidence interval (CI)50.57-2.71]. There was positive correlation between MRI and B-mode CSA (Spearman's r50.48; 95% CI 0.11-0.73; p50.011) and the slope of linear regression was significantly non-zero (1.23; 95% CI50.68-1.77; p,0.0001). Conclusions: HIFU ablation of liver tumours is safe and feasible. HIFU treatment is accurate, and intra-operative assessment of treatment provides an accurate measure of the zone of ablation and correlates well with MRI follow-up. Colorectal cancer is one of the leading causes of mortality in Europe and the USA [1]. Of those diagnosed with colorectal cancer, 20-30% will have metastases in the liver at the time of diagnosis, and overall 50% will develop liver metastases during the course of their disease [2,3]. Despite this, at post-mortem, approximately one-quarter of patients are found to have metastases confined to the liver, and so the possibility of cure in such patients is available if these metastases can be treated effectively. Hepatic resection is feasible in only 10-25%, and although it is associated with an operative mortality of up to 5%, it can achieve 5-year survival rates in the region of 40% [4]. The favoured current alternative to surgery is combination chemotherapy, but this is associated with an objective response rate of just 20-50%, and relatively short median overall survival of approximately 12 months [5]. As a result there have been considerable efforts to provide minimally invasive alternatives to surgery for these patients. These alternatives include transarterial chemo-embolisation (TACE), direct percutaneous ethanol injection (PEI), and energy-based ablative techniques such as radiofrequency ablation (RFA), cryoablation, microwave th...

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

High-intensity focused ultrasound treatment of liver tumours: post-treatment MRI correlates well with intra-operative estimates of treatment volume

Leslie

Ritchie²,

Illing³

et al. 2012

BJR

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“…Colorectal cancer (CRC) is one of the leading causes of mortality and accounts for 200,000 deaths per year in Europe and USA. 36 CRC is probably the type of cancer for which the most is known about the genes affected by somatic mutations, their normal functions and their carcinogenic effects when mutated; limited evidence is available about the influence of genetic polymorphisms on clinical outcome, most of the studies have been focused on genes encoding for metabolism enzymes as well as genes encoding DNA synthesis and repair enzymes. 37 Selectins have been shown to play a critical role in tumor cell-endothelial cell interaction in CRC.…”

Section: Discussionmentioning

confidence: 99%

Role of S128R polymorphism of E‐selectin in colon metastasis formation

Alessandro

Seidita

Flugý

et al. 2007

Intl Journal of Cancer

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The extravasation of cancer cells is a key step of the metastatic cascade. Polymorphisms in genes encoding adhesion molecules can facilitate metastasis by increasing the strength of interaction between tumor and endothelial cells as well as impacting other properties of cancer cells. We investigated the Ser128Arg (a561c at the nucleotide level) polymorphism in the E-selectin gene in patients with metastatic colon cancer and its functional significance. Genotyping for a561c polymorphism was performed on 172 cancer patients and on an age-matched control population. The colon cancer group was divided into groups with (M 1 ) and without observable metastasis (M 2 ). For in vitro functional assays, Huvec transfected cells expressing wild-type (WT) or the S128R variant of E-selectin were established to study in vitro binding ability and signal transduction processes of T84 colon cancer cell line. Our results demonstrated that the Arginine 128 allele was more prevalent in the M 1 group than in the M 2 group or normal controls (p < 0.005; odds ratio, 1.56; 95% confidence interval (CI) 1.16-1.92; p < 0.001, odds ratio 5 1.65; CI 5 1.24-1.99, respectively). In vitro, S128R E-selectin transfected Huvec cells, supported increased adhesion as well as increased cellular signaling of T84 cancer cells compared to WT E-selectin and mock-transfected Huvec cells. These findings suggest that the E-selectin S128R polymorphism can functionally affect tumor-endothelial interactions as well as motility and signaling properties of neoplastic cells that may modulate the metastatic phenotype. ' 2007 Wiley-Liss, Inc.Key words: E-selectin; colon cancer; genetic polymorphisms; metastasis; cell signaling Metastasis is the main cause of death for cancer patients. Metastatic dissemination is a complex process, depending on the ability of malignant cells to escape from the primary tumor, penetrate and flow through the bloodstream, adhere to the vascular bed and then invade and proliferate in the organ parenchyma.1 Interactions of blood-borne carcinoma cells and the microvasculature are essential prerequisites for metastasis to occur. These processes involve mechanical contact and transient attachment, which are mediated by endothelial surface adhesion molecules and their ligands on the neoplastic cells.2 Factors mediating these interactions are therefore viewed as important determinants of the metastatic phenotype. Among the molecules mediating tumor-endothelium interactions are selectins. [3][4][5][6][7] The selectins are a small family of intercellular adhesion molecules with 3 members: E-, P-and Lselectin. They share a mosaic structure consisting of an amino-terminal domain followed by an epidermal growth factor (EGF)-like domain, a variable number of complement regulatory repeats, a transmembrane domain and a short cytoplasmic domain. E-selectin (ELAM-1) is expressed by endothelial cells, which are activated by cytokines released during the inflammatory process and plays an important role in neutrophil extravasation into injured tissues as w...

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“…Sanayileşmiş Batı toplumlarında kolorektal kanserler ölüm nedenleri arasında halen 3. sırada yer almakta ve KRK sıklığı bu ülkelerde giderek artmaktadır (4,5) . KRK'in yüksek mortalite ve morbidite oranları KRK için tarama ve primer korunma stratejilerinde çalışılması zaruretini getirmektedir.…”

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