Colorectal cancer: a comprehensive review of carcinogenesis, diagnosis, and novel strategies for classified treatments

Abedizadeh, Roya; Majidi, Fateme; Khorasani, Hamid Reza; Abedi, Hassan; Sabour, Davood

doi:10.1007/s10555-023-10158-3

Cited by 11 publications

(1 citation statement)

References 164 publications

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“…The continuous development of treatment technologies has enabled patients with early-stage CRC to achieve long-term survival through surgical tumor resection. However, those with advanced-stage CRC still have no chance of recovery 2 , 3 . Therefore, early preoperative diagnosis can provide vital information for treatment-related decision-making.…”

Section: Introductionmentioning

confidence: 99%

Changes in subset distribution and impaired function of circulating natural killer cells in patients with colorectal cancer

Zu,

Lu,

Xing

et al. 2024

Sci Rep

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Natural killer (NK) cells are closely associated with malignant tumor progression and metastasis. However, studies on their relevance in colorectal cancer (CRC) are limited. We aimed to comprehensively analyze the absolute counts, phenotypes, and function of circulating NK cells in patients with CRC using multiparametric flow cytometry. The distribution of NK cell subsets in the peripheral circulation of patients with CRC was significantly altered relative to the control group. This is shown by the decreased frequency and absolute count of CD56dimCD16+ NK cells with antitumor effects, contrary to the increased frequency of CD56bright NK and CD56dimCD16- NK cells with poor or ineffective antitumor effects. NK cells in patients with CRC were functionally impaired, with decreased intracellular interferon (IFN)-γ secretion and a significantly lower percentage of cell surface granzyme B and perforin expression. In addition, IFN-γ expression decreased significantly with the tumor stage progression. Based on a comprehensive analysis of the absolute counts, phenotypes, and functional markers of NK cells, we found an altered subset distribution and impaired function of circulating NK cells in patients with CRC.

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Section: Introductionmentioning

confidence: 99%