Colorectal Cancer: A Large Unselected Australian Series

Davis, NevilleC.; Evans, Elizabeth; Cohen, J.; Theile, David E.; Job, DavidM.

doi:10.1111/j.1445-2197.1987.tb01326.x

Cited by 13 publications

(2 citation statements)

References 17 publications

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“…Most cancer related deaths are not caused by the primary cancer site, but by distant metastasis. However, patients without distant metastasis at the time of surgery (UICC I to III) still have improvable 5-year survival rates between 41% and 96% [2,3]. …”

Section: Introductionmentioning

confidence: 99%

Is the lymph node ratio superior to the Union for International Cancer Control (UICC) TNM system in prognosis of colon cancer?

et al. 2013

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BackgroundDecision making for adjuvant chemotherapy in stage III colon cancer is based on the TNM system. It is well known that prognosis worsens with higher pN classification, and several recent studies propose superiority of the lymph node ratio (ln ratio) to the TNM system. Therefore, we compared the prognosis of ln ratio to TNM system in our stage III colon cancer patients.MethodsA total of 939 patients underwent radical surgery for colorectal cancer between January 2000 and December 2009. From this pool of patients, 142 colon cancer stage III patients were identified and taken for this analysis. Using martingale residuals, this cohort could be separated into a group with a low ln ratio and one with a high ln ratio. These groups were compared to pN1 and pN2 of the TNM system.ResultsFor ln ratio, the cutoff was calculated at 0.2. There was a good prognosis of disease-free and cancer-related survival for the N-category of the TNM system as well as for the lymph node ratio. There was no statistical difference between using the N-category of the TNM system and the ln ratio.ConclusionsThere might not be a benefit in using the lymph node ratio rather than the N category of the TNM system as long as the number of subgroups is not increased. In our consideration, there is no need to change the N categorization of the TNM system to the ln ratio.

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Section: Introductionmentioning

confidence: 99%

Is the lymph node ratio superior to the Union for International Cancer Control (UICC) TNM system in prognosis of colon cancer?

et al. 2013

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“…Most cancer-related deaths are not caused by the primary cancer site, but by distant metastasis. However, patients without distant metastasis at the time of surgery (International Union Against Cancer (UICC) stages I to III) still have unsatisfying five-year survival rates between 41% and 96% [2,3]. …”

Section: Introductionmentioning

confidence: 99%

A novel sialyl LeX expression score as a potential prognostic tool in colorectal cancer

et al. 2012

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BackgroundTreatment decisions in colorectal cancer subsequent to surgery are based mainly on the TNM system. There is a need to establish novel prognostic markers based on the molecular characterization of tumor cells. Evidence exists that sialyl LeX expression is correlated with an unfavorable outcome in colorectal cancer. The aim of this study was to establish a simple sialyl LeX staining score and to determine a potential correlation with the prognosis in a series of advanced colorectal carcinoma patients.MethodsIn order to implement routine use of sialyl LeX immunohistology, we established a new, easily reproducible score and defined a cutoff which discriminated groups with better or worse outcome, respectively. We then correlated sialyl LeX expression of 215 UICC stage III and IV patients with disease-free and cancer-related survival.ResultsA five-stage score could be established based on automated immunohistochemical stainings. Using a statistical model, we calculated a cutoff to discriminate between weak and strong staining positivity of sialyl LeX. Patients with strong positive specimens had a worse cancer-related survival (P = 0.004) but no difference was observed for disease-free survival (P = 0.352).ConclusionsThese results demonstrate a strong correlation between high sialyl LeX-expression in colorectal carcinomas and cancer-related survival. Our highly standardized and easy-to-use staining score is suitable for routine use and hence it could be recommended to evaluate sialyl LeX-expression as part of the standard histopathological analysis of colorectal carcinomas and to validate the score prospectively based on a larger population.

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High-Dose Preoperative Radiation and Radical Sphincter-Preserving Surgery for Rectal Cancer

Marks

Mohiuddin²,

Eitan³

et al. 1991

Arch Surg

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To reduce local recurrence associated with rectal cancer and to extend the scope of anal sphincter preservation, a selective program of high-dose preoperative radiation therapy and sphincter-preserving surgery was initiated in 1976. High-energy photon therapy (40 to 60 Gy) was administered in doses of 1.8 to 2.5 Gy during a period of 4 1/2 to 6 weeks and followed in 4 to 6 weeks with curative sphincter-preserving surgery for clinicopathologically unfavorable and low rectal cancers. None of the 143 patients in the study died during the postoperative period. Fifteen (13%) of 117 patients followed up for at least 24 months experienced local recurrence. Acceptable sphincter function was retained in 130 patients (91%). Our program of high-dose preoperative radiation therapy and sphincter-preserving surgery for the treatment of high-risk cancers, including those in the distal third of the rectum, resulted in better-than-expected survival and control of local recurrence with acceptable morbidity and no mortality.

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Colorectal Cancer: A Large Unselected Australian Series

Cited by 13 publications

References 17 publications

Is the lymph node ratio superior to the Union for International Cancer Control (UICC) TNM system in prognosis of colon cancer?

Is the lymph node ratio superior to the Union for International Cancer Control (UICC) TNM system in prognosis of colon cancer?

A novel sialyl LeX expression score as a potential prognostic tool in colorectal cancer

High-Dose Preoperative Radiation and Radical Sphincter-Preserving Surgery for Rectal Cancer

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