Colorectal cancer among farmers in the AGRICAN cohort study

Talibov, Madar; Tual, Séverine; Morlais, Fabrice; Meryet‐Figuiere, Matthieu; Boulanger, Mathilde; Bouvier, Véronique; Perrier, Stéphanie; Clin, Bénédicte; Baldi, Isabelle; Lebailly, Pierre; Dabakuyo-Yonli, S.; Bara, Simona; Bouvier, Anne; Busquet, T.; Colonna, Marc; Coureau, Gaëlle; Delanoe, Marc; Grosclaude, Pascale; Guizard, Anne‐Valérie; Herbrecht, P.; Laplante, Jean‐Jacques; Lapôtre-Ledoux, Bénédicte; Launoy, Guy; Lenoir, Didier; Hammas, K.; Marcotullio, Elisabeth; Maynadié, Marc; Molinié, F.; Monnereau, Alain; Paumier, A.; Jarriges, J.; Thibaudier, J.M.; Troussard, Xavier; Velten, Michel; Wavelet, E.; Woronoff, Anne‐Sophie

doi:10.1016/j.canep.2022.102125

Cited by 4 publications

(3 citation statements)

References 41 publications

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“…At this stage, it would be arbitrary to infer any causal relationship between the alterations in DNA damage we observe and a specific cancer risk. Moreover, our study, unlike most others, is reporting results specific for women, who can experience cancer risks different from men for similarly reported exposures, such as for CRC and pig farming (Talibov et al 2022 ), or for bladder cancer where the risk reported in women is higher than in men for field-grown vegetables workers (Boulanger et al 2017 ). If anything, observed modifications in the level of DNA damage associated with exposure to meadows, poultry and pig farming, underline that these exposures do impact women biology at the level of DNA damage in circulating PBMC, and hence alter genome stability.…”

Section: Discussionmentioning

confidence: 68%

“…However, poultry (Beane Freeman et al 2012 ) and pig (Hofmann et al 2018 ) farming were associated with a decreased risk of lung cancer in the AHS cohort, whereas such associations were not present in the AGRICAN cohort (Tual et al 2017 ). Additionally, raising poultry was associated with a greater risk of colorectal cancer (CRC) in AHS (Beane Freeman et al 2012 ) and AGRICAN (Talibov et al 2022 ), and pig farming with an increase in meningioma (Piel et al 2017 ) and CRC risk (Talibov et al 2022 ) in AGRICAN, although this last association does not last when only women are considered.…”

Section: Discussionmentioning

confidence: 99%

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Agricultural exposures and DNA damage in PBMC of female farmers measured using the alkaline comet assay

Evenden,

Vandoolaeghe,

Lecluse

et al. 2024

Int Arch Occup Environ Health

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Objective Several studies investigated the link between agricultural occupational exposures and DNA damage, in an attempt to bring elements of biological plausibility to the increased cancer risk associated with them. However, only a few of these studies focused on females. Methods The comet assay was performed on PBMC (Peripheral Blood Mononuclear Cells) samples from 245 females working in open field farming and cattle raising, located in the Normandy area of France. Individual questionnaires on tasks performed were administered at the time of sampling to directly assess exposures. Environmental exposures were issued from a questionnaire assessing the farm productions. Linear regression analyses were done using the DNA damage scores. Results Regarding direct exposures, several tasks associated with exposure to potentially harmful chemicals were not associated with DNA damage, but a longer duration of use of herbicide on meadows (p = 0.05) or of cleaning and upkeep of agricultural equipment (p = 0.06) revealed higher DNA damage levels, although the number of exposed women was low. Several indirect and/or environmental exposures were associated with DNA damage in multivariate analyses: a larger surface of meadows (p = 0.006) or the presence of poultry (p = 0.03) was associated with less DNA damage, while the presence of swine (p = 0.01) was associated with higher DNA damage. Smokers and former smokers had less DNA damage than non-smokers (p = 0.0008 and p = 0.03). Conclusions We report modified levels of DNA damage for those environmentally exposed to meadows, poultry and pig farming, underlining the need for a better knowledge of the potential health risks experienced by females in this setting.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Agricultural exposures and DNA damage in PBMC of female farmers measured using the alkaline comet assay

Evenden,

Vandoolaeghe,

Lecluse

et al. 2024

Int Arch Occup Environ Health

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“…Human exposure to pesticides has been linked to age-associated diseases, such as cancer, − particularly for chronically exposed rural workers. − Cancers of the thyroid, skin, kidneys, lymph nodes, larynge, lung, colon, and prostate have been reported to have a significantly higher incidence in pesticide-spraying farmers.…”

Section: Introductionmentioning

confidence: 99%

Exposure to Pesticides and Breast Cancer in an Agricultural Region in Brazil

Panis,

Candiotto,

Gaboardi

et al. 2024

Environ. Sci. Technol.

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Rural workers are disproportionally exposed to pesticides and might be at an increased risk of developing chronic diseases. Here, we investigated the impact of pesticide exposure on breast cancer (BC) risk and disease profile in rural female workers. This is a case-control study that prospectively included 758 individuals. The study was conducted in the Southwest region of Paranástate in Brazil, a region characterized by familybased agriculture and intensive use of pesticides. We found that this region has a 41% higher BC diagnosis rate and 14% higher BC mortality rate than the mean rates in Brazil, as well as a pesticide trade volume about 6 times higher than the national average. We showed substantial exposure in this population and found that even women who did not work in the fields but performed equipment decontamination and clothes washing of male partners who worked in the fields had urine samples positive for glyphosate, atrazine, and/or 2,4-D. The crude association showed a significantly higher risk of BC among women exposed to pesticides (OR: 1.58, 95% CI 1.18−2.13). Adjusted analyses showed a lower and nonstatistically significant association (OR: 1.30, 95% CI 41 0.87−1.95). Stratification on disease profile showed a significantly higher risk of lymph node metastasis (adjusted OR: 2.19, 95% CI 1.31−3.72) in women exposed to pesticides. Our findings suggest that female populations exposed to pesticides are at a higher risk of developing BC with a more aggressive profile and draw attention to the need to monitor rural populations potentially exposed to pesticides in the field or at home.

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