Colorectal Cancer and its Association with the Metabolic Syndrome: a Malaysian Multi-Centric Case-Control Study

Ulaganathan, Vaidehi; Kandiah, Mirnalini; Shariff, Zalilah Mohd; Faizal, J. A.; Fijeraid, Henry; Normayah, K; Gooi, Boon-Hui; Othman, Radwa E.

doi:10.7314/apjcp.2012.13.8.3873

Cited by 19 publications

(15 citation statements)

References 19 publications

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“…However, the standard protocol recommends that screening is initiated after the age of 50 years. Previous studies have suggested that there is a certain degree of correlation between metabolic syndrome and colorectal adenoma, a precancerous lesion of CRC (12)(13)(14), our study aimed to develop a risk determinant for younger patients who may benefit from screening on the basis of their metabolic profiles and associated clinical history. The general adenoma detection rate of 20% for both sexes, 23% in males and 17% in females, is in line with standard quality indicators in colonoscopic practice (15).…”

Section: Discussionmentioning

confidence: 99%

Predicting the occurrence of cancer-associated colorectal polyp using a metabolic risk score

Orannapalai

Attawettayanon

Kanngern

et al. 2013

Molecular and Clinical Oncology

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Abstract. This study was conducted with the aim of developing a metabolic risk score to help identify patients who are likely to have a cancer-associated polyp (CAP) on colonoscopy, based on a metabolic syndrome-related clinical profile. The clinical history and anthropometric and metabolic profiles of patients who came for a screening colonoscopy at our institute between June, 2010 and December, 2012 were prospectively collected. The data were analyzed for their association with the occurrence of CAP. Subsequently, six parameters were selected in order to construct a metabolic risk score that correlated with the presence of CAP. A total of 286 subjects (132 males and 154 females), with an age range of 19-85 years, were included in this study. The colonoscopy detected polyps in 56 cases (19.6%). Anthropometric parameters that were significantly associated with CAP included a body mass index (BMI) of >23.4 kg/m 2 and a waist circumference of >32 inches in females. Laboratory profiles that were significantly associated with CAP were fasting blood sugar (FBS) >110 mg%, hemoglobin A1C (HbA1C) >7%, aspartate transaminase (SGOT) >40 IU̸l, alanine transaminase (SGPT) >50 IU̸l and uric acid >7 mg%. When a metabolic risk score was constructed, it was observed that moderate (2-3) and high risk (4-6) was significantly associated with CAP [odds ratio (OR)=4.9, 95% confidence interval (CI): 2.0-12.0 and OR=13.7, 95% CI: 4.4-43.0, respectively]. The association between the risk score and CAP was stronger in the subgroup of patients aged <65 years, in whom the moderate and high metabolic risk groups exhibited ORs of 5.6 (95% CI: 1.8-17.9) and 39.0 (95% CI: 8.2-186.6), respectively. In conclusion, this study demonstrated that it is possible to use a metabolic profile to construct a reliable scoring method to identify patients at higher risk of having CAP who should be fast-tracked for a colonoscopy.

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Section: Discussionmentioning

confidence: 99%

Predicting the occurrence of cancer-associated colorectal polyp using a metabolic risk score

Orannapalai

Attawettayanon

Kanngern

et al. 2013

Molecular and Clinical Oncology

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“…As for survivors of adult-onset solid tumors, most studies were limited to some specific cancer types such as testicular cancer and prostate cancer (Nuver et al, 2005;Braga-Basaria et al, 2006;Haugnes et al, 2007). Several studies from adult-onset solid tumors have demonstrated that the results were inconsistent according to types of cancer and treatment modalities (Nuver et 1774 Haugnes et al, 2007;Liavaag et al, 2009;Ulaganathan et al, 2012). A recent meta-analysis showed no significant association with metabolic syndrome for non-hematologic malignancies (Jung et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of the Metabolic Syndrome and Associated Factors in Korean Cancer Survivors

Lee¹,

Park²,

Song³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…According to the definition of American Heart Association/The National Heart Lung and Blood Institute (AHA/NHLBI), which is the widely accepted one of numerous MetS definitions,damage/repair malfunction, local inflammation and insulin-like growth factor 1 (Guo et al, 2013;. It has been linked to certain types of cancer including breast cancer (Ronco et al, 2012), biliary tract cancer (Wu et al, 2012), colorectal cancer (Morita et al, 2005;Kaneko et al, 2010;Forootan et al, 2012;Ulaganathan et al, 2012) and aggressive urologic cancers involving prostate (Hammarsten and Peeker, 2011; and bladder . However, less is known about the possible link between MetS and RCC.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Syndrome Prevalence in Renal Cell Cancer Patients

Bulut¹,

Aktaş²,

Erkmen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Colorectal Cancer and its Association with the Metabolic Syndrome: a Malaysian Multi-Centric Case-Control Study

Cited by 19 publications

References 19 publications

Predicting the occurrence of cancer-associated colorectal polyp using a metabolic risk score

Predicting the occurrence of cancer-associated colorectal polyp using a metabolic risk score

Prevalence of the Metabolic Syndrome and Associated Factors in Korean Cancer Survivors

Metabolic Syndrome Prevalence in Renal Cell Cancer Patients

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