2022
DOI: 10.3390/nu14194185
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Colorectal Cancer and the Role of the Gut Microbiota—Do Medical Students Know More Than Other Young People?—Cross-Sectional Study

Abstract: (1) Background: Malignant neoplasms account for an increasing share of the disease burden of the world population and are an increasingly common cause of death. In the aspect of colorectal cancer, increasing attention is paid to the microbiota. According to current knowledge, the composition of gut microbiota in patients diagnosed with colorectal cancer significantly differs from the composition of microorganisms in the intestines of healthy individuals. (2) Material and methods: The survey included 571 studen… Show more

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Cited by 6 publications
(3 citation statements)
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“…In addition alterations in the microbiota in the gut may also be responsible for the increased risk of IBS with oral ulcers (21). The human gut contains a diverse microbial ecosystem, collectively known as the gut microbiota (22), which plays an important role in digestion, metabolism and immune system regulation (23). Disturbances in this ecosystem can trigger various pathological processes, including in ammation and immune dysregulation.…”
Section: Discussionmentioning
confidence: 99%
“…In addition alterations in the microbiota in the gut may also be responsible for the increased risk of IBS with oral ulcers (21). The human gut contains a diverse microbial ecosystem, collectively known as the gut microbiota (22), which plays an important role in digestion, metabolism and immune system regulation (23). Disturbances in this ecosystem can trigger various pathological processes, including in ammation and immune dysregulation.…”
Section: Discussionmentioning
confidence: 99%
“…An important factor modulating the composition of the gut microbiota is a well-balanced diet based on whole-grain products and large amounts of vegetables and fruit, which are sources of dietary fiber. In contrast, the 'Western' dietary model, which includes a high intake of processed and high-fat products, positively correlates with the development of intestinal dysbiosis, which can cause gastrointestinal symptoms [18][19][20]. In addition, the presence of gastrointestinal dysbiosis influences the increased incidence of abnormal eating behaviors, which in most cases include irregular food intake as well as food avoidance.…”
Section: The Brain-gut Axis In the Context Of Gastrointestinal (Gi) T...mentioning
confidence: 99%
“…Meanwhile, a growing body of research suggests an inseparable relationship between the occurrence and development of adult tumors and the gut microbiota. For instance, resident gut bacteria can influence patients' response to cancer immunotherapy ( 23 ), the gut microbiota possesses a unique ability to influence the tumor microenvironment as well as the metabolism of chemotherapy drugs or medications ( 24 ), the gut microbiota can modulate melanoma patients' response to PD-1 immunotherapy ( 25 ), the gut microbiota and its metabolites change with different stages of lung cancer development ( 26 ), the composition of the gut microbiota in patients diagnosed with colorectal cancer differs significantly from that of healthy individuals ( 27 ), based on specific changes in the gut microbiota, it is possible to screen for gut microbiota-targeted biomarkers and establish a diagnostic model, potentially serving as a non-invasive tool for distinguishing hepatocellular carcinoma ( 28 ), However, many aspects, including the mechanisms of onset, age of onset and characteristic features, differ between pediatric tumors and adult tumors. For instance, compared to adult tumors, childhood tumors generally exhibit a lower overall mutation burden ( 9 ).…”
Section: Introductionmentioning
confidence: 99%