Colorectal Cancer-Associated Spontaneous Tumor Lysis Syndrome: a Case Report and Review of the Current Literature

Kearney, Matthew; Chen, Emerson Y.; Stenzel, Peter; Corless, Christopher L.; DeLoughery, Thomas G.; Zivney, Mark; Lopez, Charles D.

doi:10.1007/s12029-018-0102-7

Cited by 7 publications

(7 citation statements)

References 32 publications

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“…Additionally, they found extensive necrosis within a large pulmonary tumor [26]. Moreover, similar findings were reported by Kearney et al where an autopsy in a patient with STLS revealed extensive tumor necrosis, widespread tumor thrombi in portal venous branches, pulmonary tumor deposits, and near-total replacement of lymph nodes with tumor and necrosis [27]. These findings indicate that TLS stemming from a solid tumor likely induces necrosis within both tumor and non-tumor cells that are distant from the tissue of origin.…”

Section: Human Autopsy Studiessupporting

confidence: 78%

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Tumor Lysis Syndrome in Solid Tumors: A Comprehensive Literature Review, New Insights, and Novel Strategies to Improve Outcomes

Findakly

Luther

Wang

2020

Cureus

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Tumor lysis syndrome (TLS) is a life-threatening oncological condition that is typically characterized by metabolic derangements that are often labeled as an acute kidney injury. The recent advancement in cancer treatment has led to the mounting rate of TLS in solid tumors that were previously rarely linked to this complication. Given that its prognosis is dismal, it is essential to increase recognition of this condition by describing more sensitive markers. Currently, the management of TLS is mainly supportive due to the lack of specific therapy targeting its specific pathology. This review aims to summarize the most recent literature on the underlying mechanism of TLS and the potential implications for novel TLS therapy.

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Section: Human Autopsy Studiessupporting

confidence: 78%

“…Several documented case reports of TLS in humans appear to echo animal model findings, as microemboli appear to play a direct role in widespread tissue damage [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. The demographics, clinicopathologic features, autopsy findings, and outcomes are summarized in Table 2.…”

Section: Human Autopsy Studiesmentioning

confidence: 99%

Tumor Lysis Syndrome in Solid Tumors: A Comprehensive Literature Review, New Insights, and Novel Strategies to Improve Outcomes

Findakly

Luther

Wang

2020

Cureus

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“…Tumor lysis syndrome results from the massive destruction of neoplastic cells, most often following a chemotherapy or radiation therapy [1,4,5]. More rarely, it can occur spontaneously or following hormone therapy, immunotherapy or corticosteroid therapy [3][4][5]. This syndrome most often associates hyperuricemia hyperkalemia, hyperphosphatemia, hypocalcemia and renal failure [1].…”

Section: Discussionmentioning

confidence: 99%

“…The low prevalence of this syndrome in the case of solid tumors is mainly explained by their low proliferative index and their relatively slow response to specifi c treatments [6][7][8]. Most cases of solid tumors complicated by lysis syndrome are of endocrine origin with small cells, especially of bronchial localization [3,4,9]. Other histological types have also been described, such as choriocarcinoma or leimyosarcoma [3].…”

Section: Discussionmentioning

confidence: 99%

Tumor lysis syndrome after chemotherapy for metastatic colic carcinoma: About two adult cases

Abaza¹,

Sallami²,

A³

et al. 2020

Arch Clin Gastroenterol

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Tumor Lysis Syndrome (TLS) is a major oncological emergency involving metabolic perturbations. It occurs when tumor cells release their contents into the bloodstream, either spontaneously or in response to therapy. TLS is characterized by hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia following massive lysis of malignant cells. Although this syndrome is well described, it is rarely seen or suspected in solid malignancies. The frequency and severity of TLS is partly dependent upon the biology of the disease and type of therapy administered. We report in this work two cases of tumor lysis syndrome occurring after chemotherapy for endocrine colon carcinoma with small metastatic cells.

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“…When the balance between the oncogene and the tumor suppressor gene is disrupted, the expression of the oncogene that controls cell proliferation is sustained or upregulated and the tumor suppressor gene is not expressed or is inactivated; thus, the cancerous cell escapes the control of the body’s immune mechanism and forms a tumor. 5 This leads to the deterioration and metastasis of cells. The detection of cancer-related genes is of clinical significance in predicting the occurrence, development, therapeutic effect, and prognosis of colon cancer.…”

Section: Introductionmentioning

confidence: 99%

Upregulation of SOX18 in colorectal cancer cells promotes proliferation and correlates with colorectal cancer risk

Miao¹,

Deng²,

Shuai³

et al. 2018

OTT

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BackgroundSince colorectal cancer (CRC) is one of the most common malignant tumors worldwide, we aimed to identify the role of sex determining region Y (SRY)-box 18 (SOX18) in CRC.MethodsRT-PCR and immunohistochemistry were employed to detect the expression of SOX18 in CRC samples. We then identified the effect of SOX18 on cell proliferation, cell cycle, and apoptosis by cell counting kit-8 (CCK-8), flow cytometry, and annexin V/PI staining, respectively. The effect of silencing SOX18 expression in CRC development was evaluated by using a xenograft mouse model.ResultsFirst, we found that SOX18 was overexpressed in CRC tissues and cell lines and that SOX18 levels in CRC tissues were positively associated with advanced clinical stages, vascular invasion, and lymph node metastasis. Furthermore, patients with higher expression of SOX18 had a lower survival rate. Overexpression of SOX18 significantly promoted cell proliferation, promoted S cell cycle progression, and inhibited cell apoptosis. Conversely, downregulation of SOX18 clearly weakened cell proliferation, induced G0/G1 cell cycle phase arrest, and gave rise to cell apoptosis. The results showed that shSOX18 significantly inhibited tumor growth and weight. Ki67 expression was also decreased by SOX18 silencing treatment.ConclusionOur study indicates that SOX18 may have a carcinogenic effect on CRC, which might provide novel insights into CRC prevention and treatment.

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Colorectal Cancer-Associated Spontaneous Tumor Lysis Syndrome: a Case Report and Review of the Current Literature

Cited by 7 publications

References 32 publications

Tumor Lysis Syndrome in Solid Tumors: A Comprehensive Literature Review, New Insights, and Novel Strategies to Improve Outcomes

Tumor Lysis Syndrome in Solid Tumors: A Comprehensive Literature Review, New Insights, and Novel Strategies to Improve Outcomes

Tumor lysis syndrome after chemotherapy for metastatic colic carcinoma: About two adult cases

Upregulation of SOX18 in colorectal cancer cells promotes proliferation and correlates with colorectal cancer risk

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