Colorectal cancer care knowledge mapping: identifying priorities for knowledge translation research

Gagliardi, Anna R.; Wright, Frances C.; Grunfeld, Eva; Davis, Dave

doi:10.1007/s10552-008-9126-9

Cited by 4 publications

(5 citation statements)

References 140 publications

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“…However, the data presented hints that the former may be the situation since acquisition of resistance correlated better with loss of POU5F1 rather than NANOG in the NT2-NANOG cells with increasing RA treatment. This would be consistent with the recent findings of Gutekunst et al [6] who showed that POU5F1 expression is essential to provide the pro-apoptotic environment needed to maintain drug sensitivity in undifferentiated NT2-D1 cells.…”

Section: Discussionsupporting

confidence: 93%

“…Mueller et al [33] previously reported that loss of POU5F1 expression induced by differentiating GCT cell lines with a medium containing fetal bovine serum and steroids resulted in cDDP resistance, and this has been confirmed by knockdown of POU5F1 [6]. This is consistent with other studies reporting that differentiation of embryonal carcinoma cells leads to induction of resistance [20].…”

Section: Discussionsupporting

confidence: 81%

“…Attempts to identify mechanisms underlying the initial sensitivity of GCTs to the Pt drugs have included studies of: 1) drug accumulation; 2) drug detoxification; 3) DNA repair; and, 4) apoptotic mechanisms [1], [2]. However, results have been conflicting and there remains uncertainty as to what cellular pathways are the most important with regard to the initial sensitivity of the tumor or the emergence of resistance during treatment [3]–[6].…”

Section: Introductionmentioning

confidence: 99%

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Cisplatin Induces Resistance by Triggering Differentiation of Testicular Embryonal Carcinoma Cells

Abada

Howell

2014

PLoS ONE

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Although testicular germ cell tumors are generally quite responsive to treatment with cisplatin, a small fraction of them acquire resistance during therapy. Even when cisplatin treatment is successful the patient is often left with a residual teratoma at the site of the primary tumor suggesting that cisplatin may trigger differentiation in some tumors. Using the human embryonal carcinoma cell line NTera2/D1, we confirmed that exposure to the differentiating agent retinoic acid produced a reduction in pluripotency markers NANOG and POU5F1 (Oct3/4) and an acute concentration-dependent increase in resistance to both cisplatin and paclitaxel that reached as high as 18-fold for cisplatin and 61-fold for paclitaxel within four days. A two day exposure to cisplatin also produced a concentration-dependent decrease in the expression of the NANOG and POU5F1 and increased expression of three markers whose levels increase with differentiation including Nestin, SCG10 and Fibronectin. In parallel, exposure to cisplatin induced up to 6.2-fold resistance to itself and 104-fold resistance to paclitaxel. Paclitaxel did not induce differentiation or resistance to either itself or cisplatin. Neither retinoic acid nor cisplatin induced resistance in cervical or prostate cancer cell lines or other germ cell tumor lines in which they failed to alter the expression of NANOG and POU5F1. Forced expression of NANOG prevented the induction of resistance to cisplatin by retinoic acid. We conclude that cisplatin can acutely induce resistance to itself and paclitaxel by triggering a differentiation response in pluripotent germ cell tumor cells.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

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Cisplatin Induces Resistance by Triggering Differentiation of Testicular Embryonal Carcinoma Cells

Abada

Howell

2014

PLoS ONE

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“…Academic family medicine departments are increasingly recognizing the importance of educational research and are creating support structures for its advancement. Researchers have advocated for the development of programs of research rather than the conduct of single studies [ 16 , 17 ]. Regehr [ 5 ] noted that there is a distinction between scholars working on the same topic and scholars working toward a shared goal.…”

Section: Introductionmentioning

confidence: 99%

A scoping review of medical education research in family medicine

Webster

Krueger

MacDonald³

et al. 2015

BMC Med Educ

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BackgroundLittle is known about the state of education research within family medicine. As family medicine education models develop, it is important to develop an understanding of the current state of this research and develop ways to advance the field.MethodsWe conducted a scoping review of family medicine education research to describe 1) research topic areas and 2) the methodologies and methods used to study these topics. MEDLINE, Social Sciences Abstracts and ERIC electronic databases were searched. 817 full text articles from 2002 to 2012 were screened; 624 articles were included in the review.ResultsThe following research topic areas were identified: continuing education, curriculum development, undergraduate education, teaching methods, assessment techniques, selection of entrants, non-clinical skills, professional and faculty development, clinical decision-making and resident well-being. Quantitative studies comprised the large majority of research approaches; overall minimal methodological details were provided.ConclusionsOur review highlights an overall need for increased sophisticated in methodological approaches to education research in family medicine, a problem that could be ameliorated by multiple strategies including better engagement of methodologists throughout the research process. The results provide guidance for future family medicine education research programs.

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“…Most strategies are not routinely applied outside of experimental studies and few program evaluations are published which would provide information about the impact and implications of these strategies in a variety of contexts. By systematic review we found no studies evaluating implementation of breast cancer management guidelines [23], and only two studies evaluating implementation for colorectal cancer management guidelines [24]. Therefore, little data about cost and contextual effectiveness is available to guide decisions about which implementation strategies are most useful in the real world.…”

Section: Introductionmentioning

confidence: 99%

“More bang for the buck”: exploring optimal approaches for guideline implementation through interviews with international developers

Gagliardi

2012

BMC Health Serv Res

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BackgroundPopulation based studies show that guidelines are underused. Surveys of international guideline developers found that many do not implement their guidelines. The purpose of this research was to interview guideline developers about implementation approaches and resources.MethodsSemi-structured telephone interviews were conducted with representatives of guideline development agencies identified in the National Guideline Clearinghouse and sampled by country, type of developer, and guideline clinical indication. Participants were asked to comment on the benefits and resource implications of three approaches for guideline implementation that varied by responsibility: developers, intermediaries, or users.ResultsThirty individuals from seven countries were interviewed, representing government (n = 12) and professional (n = 18) organizations that produced guidelines for a variety of clinical indications. Organizations with an implementation mandate featured widely inconsistent funding and staffing models, variable approaches for choosing promotional strategies, and an array of dissemination activities. When asked to choose a preferred approach, most participants selected the option of including information within guidelines that would help users to implement them. Given variable mandate and resources for implementation, it was considered the most feasible approach, and therefore most likely to have impact due to potentially broad use.ConclusionsWhile implementation approaches and strategies need not be standardized across organizations, the findings may be used by health care policy makers and managers, and guideline developers to generate strategic and operational plans that optimize implementation capacity. Further research is needed to examine how to optimize implementation capacity by guideline developers, intermediaries and users.

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Colorectal cancer care knowledge mapping: identifying priorities for knowledge translation research

Cited by 4 publications

References 140 publications

Cisplatin Induces Resistance by Triggering Differentiation of Testicular Embryonal Carcinoma Cells

Cisplatin Induces Resistance by Triggering Differentiation of Testicular Embryonal Carcinoma Cells

A scoping review of medical education research in family medicine

“More bang for the buck”: exploring optimal approaches for guideline implementation through interviews with international developers

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