Colorectal Cancer Cells Adhere to Traumatized Peritoneal Tissue in Clusters, An Experimental Study

Abstract

The use of human peritoneal tissue in an ex vivo model would appear to be a potentially useful tool for the study of interaction between human peritoneal membrane and free tumor cells. Experimental surgical trauma increases the ability of tumor cells to adhere to the peritoneal membrane. This ex vivo model should be useful in future studies on biological interactions between peritoneum and tumor cells in the search for novel forms of peritoneal cancer therapy.

A human ex vivo coculture model to investigate peritoneal metastasis and innovative treatment options

“…This is an important observation with potential clinical impact, as it shows that tumor cells that are shed off from the primary tumor could attach to and grow into injured sites of the peritoneum, which was already seen in animal models [ 23 ], [ 24 ], [ 25 ], [ 26 ]. In accordance with that, previous investigations observed a tendency of colorectal tumor cell lines to adhere to traumatized sites of the peritoneum or ex vivo cultured human mesothelial cells [ 27 ].…”