Colorectal Cancer in Egypt: Clinical, Life-Style, and Socio-Demographic Risk Factors

Hassan, Ahmed M.; Khalaf, A. M.; Elias, Abd Al-Kareem

doi:10.21608/aimj.2021.79043.1490

Cited by 7 publications

(7 citation statements)

References 46 publications

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“…The third most fatal disease in the world, colorectal cancer (CRC), is regarded as one of the most common malignancies in the world. Adaptive intra-tumor immunity may help the tumor either disappear or grow 1 . CRC is regarded as the second most deadly disease, believed to be responsible for almost 935,000 cancer deaths, and it accounts for approximately 1.9 million new instances of epithelial malignancy globally, ranking third 2 .…”

Section: Introductionmentioning

confidence: 99%

Study Of Biomarkers In Colorectal Cancer Invasion To The Liver

Abdel-Hamid,

El-Awady,

Abdel- Hamid

et al. 2024

Azhar International Journal of Pharmaceutical and Medical Scien

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Objective: Colorectal liver metastases (CRLM) is the preferred target site for CRC distal metastasis, which is always a cause for high mortality rates. Additionally, metastasis is frequently accompanied by low survival rates and renders standard therapies ineffective. Finding markers for CRLM identification is thus crucial for the early detection of CRLM. Methods: In order to validate our idea, we recruited patients with CRC. Ninety-six human participants were chosen along with a case-control study. The participants were divided into 3 groups: group 1 contains 62 CRC patients, group 2 contains 34 CRLM patients, and group 3 contains 80 healthy people. Bilirubin, SGOT, SGPT, CEA, and CA19.9 were investigated in all participants. Results: In comparison to control persons, CRC patients' serum levels of CEA and CA 19-9 were considerably higher. When CRLM patients were compared to non-distant metastatic patients, CEA and CA19.9 tumor markers showed significantly higher levels. Conclusion: Our findings showed that serum levels of CEA and CA19.9 are useful diagnostic markers for CRC for detection of metastasis using disturbed liver functions as a correlative indicator.

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Section: Introductionmentioning

confidence: 99%

Study Of Biomarkers In Colorectal Cancer Invasion To The Liver

Abdel-Hamid,

El-Awady,

Abdel- Hamid

et al. 2024

Azhar International Journal of Pharmaceutical and Medical Scien

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“…About 9.4% of cancerrelated deaths were attributed to CRC in 2020 (2). In Egypt, CRC is the seventh most common cancer and the third most common male neoplasm and fifth most common female neoplasm (3).…”

Section: Introductionmentioning

confidence: 99%

Significance of Transmembrane 9 Superfamily 4 (TM9SF4) immunohistochemical expression and nuclear morphometry in premalignant colonic lesions and colorectal carcinoma

H .Shalan,

Morgan,

M.Abdrabh

et al. 2024

Benha Medical Journal

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Background: Although different markers are used as diagnostic methods for colorectal carcinoma (CRC) such as; carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9), low sensitivity and low specificity of these markers revealed the importance of searching for other markers. Transmembrane 9 Superfamily 4 (TM9SF4) is autophagic protein involved in multiple stages of tumorigenesis and development. Nuclear morphometry is a method for digital histological analysis which has been subjected to significant technological advances in the last years. Aim: To evaluate the role of Transmembrane 9 Superfamily 4 (TM9SF4) and nuclear morphometry in premalignant colonic lesions and colorectal carcinoma. Material and methods:This is a retrospective study carried on 11 ulcerative colitis cases, 16 colonic adenoma cases and 23 colorectal adenocarcinoma cases with 6 normal colon specimens as a control. Clinicopathological characteristics of examined cases were correlated with IHC of TM9SF4 and nuclear morphometry. Results: There is a significant statistical correlation between TM9SF4 scoring and different histopathological types of studied cases, lymphovascular invasion, lymph node metastasis, distant metastasis and stage of CRC. There is a significant statistical correlation between nuclear morphometry and different histopathological types of studied cases. Also, there is a significant statistical correlation between area and perimeter nuclear morphometry and perineural invasion and grade of colorectal adenocarcinoma respectively. Conclusion: TM9SF4 may have role in tumorigenesis and development of CRC and also it has a prognostic role in CRC. Nuclear morphometry may have a diagnostic role in CRC.

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“…2 Obesity, diabetes, Irritated bowel disease, precancerous colonic lesions, and family history of CRC were the highly considerable risk factors. 2 Extensive research has recommended that nutrition may play both a causal and protective role in the development of colon cancer. 3 MicroRNAs (miRNAs) are regulatory RNAs with 18-25 endogenous non-coding nucleotides that show posttranscription gene regulation.…”

Section: Introductionmentioning

confidence: 99%

Potential diagnostic role of circulating MiRNAs in colorectal cancer

Abo-Elela

Salem

Swellam³

et al. 2023

Int J Immunopathol Pharmacol

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Objectives Colorectal cancer (CRC) is the third most common and fourth most deadly cancer worldwide despite its various screening method. Thus, the search for novel and better markers is continuous. This study aimed to assess the combined expression levels of miR-133a, miR-574-3p, and miR-27a in early diagnosis of colorectal cancer in comparison to traditional tumor markers (CEA and CA19.9). Methods miR-133a, miR-574-3p, and miR-27a were assessed in sera of 120 participants categorized into healthy control group ( n = 20), benign group ( n = 30) and malignant group ( n = 70) using real-time PCR. Results miR-133a, miR-574-3p, and miR-27a expressions showed significant difference among different staging, grading and tumor size of CRC. The sensitivities of the three miRNAs whether combined or individually used were better than routinely used tumor markers (CEA and CA19.9) leading to more accurate and faster diagnosis of CRC. Conclusion Synergetic detection of miRNA-133a, miRNA-574-3p, and miRNA-27a may serve as better noninvasive biomarkers with higher combined sensitivity for early diagnosis of CRC than individual detection of miRNAs.

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Colorectal Cancer in Egypt: Clinical, Life-Style, and Socio-Demographic Risk Factors

Abstract: Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles under the following conditions: Creative Commons Attribution-Share Alike 4.0 International Public License (CC BY-SA 4.0).

Cited by 7 publications

References 46 publications

Study Of Biomarkers In Colorectal Cancer Invasion To The Liver

Study Of Biomarkers In Colorectal Cancer Invasion To The Liver

Significance of Transmembrane 9 Superfamily 4 (TM9SF4) immunohistochemical expression and nuclear morphometry in premalignant colonic lesions and colorectal carcinoma

Potential diagnostic role of circulating MiRNAs in colorectal cancer

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