Colorectal cancer in Egypt is commoner in young people: Is this cause for alarm?

Gado, Ahmed; Ebeid, Basel; Abdelmohsen, Aida; Axon, A. T. R.

doi:10.1016/j.ajme.2013.03.003

Cited by 76 publications

(90 citation statements)

References 16 publications

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“…This is a common CRC demographic feature in Egypt [17,18,24]. Also, most of positive FOBT (92.8%) had CRC, which confirms its reliability in diagnosis [25,26].…”

Section: Discussionsupporting

confidence: 68%

“…This agreed with another Egyptian studies [17,18,24]. On the contrary, Khafagy et al found the rectum the commonest site affected [27].…”

Section: Discussionsupporting

confidence: 62%

“…On the contrary, Khafagy et al found the rectum the commonest site affected [27]. One third of cases (32%) had stricture, and 4% presented with mass, which was contrary to Gado et al [17]. In addition, all cases were diagnosed as adenocarcinoma, 12% of which were mucinous adenocarcinoma.…”

Section: Discussionmentioning

confidence: 91%

“…CRC is common among Egyptian patients undergoing colonoscopy, its incidence range 10.6-14% [2,17] and its rates are high in patients younger than 40 years [17]. CRC was the 6th cancer in Egypt, representing 4% of the total cancers and 53% of GIT cancers [18].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of microRNAs-29a, 92a and 145 in colorectal carcinoma as candidate diagnostic markers: An Egyptian pilot study

Ramzy

Hasaballah

Marzaban

et al. 2015

Clinics and Research in Hepatology and Gastroenterology

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“…This is a common CRC demographic feature in Egypt [17,18,24]. Also, most of positive FOBT (92.8%) had CRC, which confirms its reliability in diagnosis [25,26].…”

Section: Discussionsupporting

confidence: 68%

“…This agreed with another Egyptian studies [17,18,24]. On the contrary, Khafagy et al found the rectum the commonest site affected [27].…”

Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of microRNAs-29a, 92a and 145 in colorectal carcinoma as candidate diagnostic markers: An Egyptian pilot study

Ramzy

Hasaballah

Marzaban

et al. 2015

Clinics and Research in Hepatology and Gastroenterology

View full text Add to dashboard Cite

“…The proportion of patients under 40 years (9%), observed in this study is higher compared with those observed in developed countries such as the USA and France, where CRC in young patients is very rare before 40 years and accounts for 1-4% [44,48,50]. CRC in young patients is more common in Maghreb countries with a proportion of 11% in Morocco and much higher in the Middle East with 18% in Turkey and 38% in Egypt [51][52][53]. CRC in young adults (under 40) is important to consider because of their poor prognosis and their family character.…”

Section: Discussionmentioning

confidence: 50%

Colorectal cancer incidence and clinicopathological features in northern Tunisia 2007–2009

Khiari

Hsaïri

2018

Colorect. Cancer

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Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. The aim of this study was to determine CRC incidence and to describe clinicopathological features in north Tunisia for the period 2007–2009. The North Tunisia Cancer Registry was the source of data for the identification of patients. The age-standardized incidence rates (ASRs) were respectively 13.6 cases (7.5/100,000 for colon cancer and 6.2 for rectal cancer) and 11.1 cases (6.5/100,000 for colon cancer and 4.4 for rectal cancer) per 100,000 among male and female. The ASR varied widely by regions in northern Tunisia. The most common site in colon cancer was the distal colon comparing to the proximal one (49.0 and 29.9% respectively). Adenocarcinoma was the most common histological type. CRC screening should be strengthened in Tunisia to achieve a reduction of CRC incidence and mortality.

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MicroRNAs expression profiling in Egyptian colorectal cancer patients

et al. 2019

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Egypt has increased incidence and high rate of early onset colorectal cancer (CRC). This study aimed to profile the expression levels of 84 circulating microRNAs (miRNAs) in Egyptian CRC patients and to evaluate the diagnostic accuracy of some selected miRNAs as diagnostic biomarkers for CRC patients. A total of 129 subjects (84 CRC patients and 45 healthy controls) were enrolled in two independent sample sets: the screening set (39 subjects) and the validation set (90 subjects). The expression profiles of 84 miRNAs were studied by miRNA PCR array in the screening set. Then four miRNAs (let‐7c, 21, 26a, 146a) were selected to be studied by quantitative real‐time PCR in the validation set. The PCR array results revealed significant up regulation of 20 miRNAs and downregulation of two miRNAs in CRC patients compared to the healthy subjects. Moreover, the expression levels of the four selected miRNAs were significantly higher in CRC serum samples than controls. The ROC analysis revealed that miRNAs (let‐7c, 21, 26a and 146a) can effectively discriminate between CRC patients and the controls. The combination of the four miRNAs showed AUC of 0.950 (95% CI [0.898–1.002], p = .001). However, the combination of miR‐21 and miR‐26a showed the best diagnostic accuracy with AUC of 0.953 (95% CI [0.908–0.999], p = .001). The current data suggest that miRNAs (let‐7c, 21, 26a, 146a) could play an important role in CRC development and they can be used as diagnostic biomarkers for CRC.

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Colorectal cancer in Egypt is commoner in young people: Is this cause for alarm?

Cited by 76 publications

References 16 publications

Evaluation of microRNAs-29a, 92a and 145 in colorectal carcinoma as candidate diagnostic markers: An Egyptian pilot study

Evaluation of microRNAs-29a, 92a and 145 in colorectal carcinoma as candidate diagnostic markers: An Egyptian pilot study

Colorectal cancer incidence and clinicopathological features in northern Tunisia 2007–2009

MicroRNAs expression profiling in Egyptian colorectal cancer patients

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