Colorectal cancer in inflammatory bowel disease: Results of the 3rd ECCO pathogenesis scientific workshop (I)

Abstract

Epidemiological studies demonstrate an increased risk of colorectal cancer in patients with inflammatory bowel disease (IBD). A detailed literature review was conducted on epidemiology, risk factors, pathophysiology, chemoprevention and outcomes of colorectal cancer (CRC) in IBD as part of the 3rd ECCO scientific pathogenesis workshop.

Desarrollo de neoplasia en pacientes con enfermedad inflamatoria intestinal

“…con la disminución en el riesgo de CCR 2,22 , dos meta-análisis recientes concluyeron que tanto la mesalazina como los tiopurínicos no tendría un rol en la prevención de CCR 23,24 . El colangiocarcinoma se ha asociado a múltiples factores de riesgo, destacando la CEP y la EII 4,25 .…”

“…Se ha señalado que pacientes con EII presentan un mayor riesgo de desarrollar neoplasias. Esto se debería, en parte, por la inflamación crónica de la mucosa intestinal, pero también secundario a manifestaciones extraintestinales de la enfermedad y al tratamiento inmunosupresor que reciben estos pacientes [1][2][3] . La EII se ha asociado a tumores malignos gastrointestinales, destacando el cáncer colorrectal (CCR) y el colangiocarcinoma, este último asociado a colangitis esclerosante primaria (CEP) 1,4 .…”

Potential markers for early diagnostics of Colorectal cancer and Inflammatory bowel disease in humans : intestinal microorganisms and immune system (teammates or rivals)

“…Enhanced inflammation in these mice resulted in increased carcinogenesis after azoxymethane (AOM) injection in comparison with wild-type mice [12]. In patients with IL-10 receptor mutation (abrogation of IL-10 signaling), timely and aggressive tumor progression was observed [25].…”

“…The suggested mechanism was the up regulation of anti-apoptotic factors. In blood sera and tumor biopsies of CRC patients, increased IL-6 concentrations were detected [25,26].…”

Colorectal Adenocarcinoma and Inflammatory Bowel Disease: An Update and Review

“…In IBD the outcomes may be worse than in the general population, with a 2 fold increase in mortality associated with IBD-associated CRC compared to sporadic cancers [10]. Although an increased CRC risk associated with IBD has been suspected, the exact effect, and its magnitude, has been difficult to determine.…”