Colorectal cancer in Iran: immunohistochemical profiles of four mismatch repair proteins

Molaei, Mahsa; Mansoori, Babak Khoshkrood; Ghiasi, Somayeh; Khatami, Fatemeh; Attarian, Hamid; Zali, Mohammad Reza

doi:10.1007/s00384-009-0784-1

Cited by 18 publications

(17 citation statements)

References 35 publications

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“…[13][14][15][16][17] Proximal tumors, which have long been associated with the MSI phenotype, were significantly overrepresented in this group. 4 Fifteen tumors had LoE of one or both components of the MLH1-PMS2 heterodimer, and the 18 had LoE of one or both components of the MSH2-MSH6 heterodimer.…”

Section: Discussionmentioning

confidence: 89%

Immunohistochemistry to Detect Hereditary Nonpolyposis Colorectal Cancer in Young Patients: the 7-Year Auckland Experience

Wright

Arnold

Parry

et al. 2011

Diseases of the Colon &Amp; Rectum

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Section: Discussionmentioning

confidence: 89%

Immunohistochemistry to Detect Hereditary Nonpolyposis Colorectal Cancer in Young Patients: the 7-Year Auckland Experience

Wright

Arnold

Parry

et al. 2011

Diseases of the Colon &Amp; Rectum

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“…Immunohistochemical staining for products of mismatch repair genes, MLH1, MSH2 and MSH6, was done according to a previously described method [15]. Intramucosal lymphocytes were used as positive controls.…”

Section: Methodsmentioning

confidence: 99%

Profile and Frequency of p53 Gene Alterations in Gastritis Lesions from Iran

Sadeghi¹,

Azimzadeh²,

Vahedi³

et al. 2010

Digestion

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Background: It has been frequently shown that p53 alterations have an important role in the development of gastric cancers but there is no data on p53 alteration in gastric cancer and its precancerous lesions from Iran although this country experiences one of the highest gastric cancer incidence and mortality rates in the world. The purpose of this study was to do a comprehensive assessment of p53 alterations in the Iranian population of gastritis patients and to evaluate the association between p53 alterations, microsatellite status and clinicopathological aspects. Methods: After DNA extraction, PCR sequencing was done for exons 2–7. Also microsatellite status was evaluated using five microsatellite markers: NR-27, NR-21, NR-24, BAT-25 and BAT-26. Results: The highest rate of alteration was seen in codons 72 (85.6%, SNP) and 248 (30.9%, mutation). Also, we found 2 new mutations in codons 9 and 146. In contrast with previous work, transition at the CpG codons was relatively rare. Nucleotide alterations were more prevalent in the Helicobacter pylori-positive group but not significantly. Neither nuclear staining for p53 protein nor microsatellite instability was seen in gastritis lesions. Conclusion: p53 alterations might contribute to the pathogenesis of gastritis and perhaps gastric cancer in Iran. However, the different spectrum seen here implies other mechanism(s) in gastritis and gastric cancer development in the Iranian population.

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“…The basic tests identify five markers (NR-21, BAT-26, BA T -25, NR-27 and NR-24) to devise the simplest diagnostic assay (9). Previous reports have shown significant diversity regarding the most common marker for microsatellite testing; BAT 25, BAT26 and NR21 have been reported in HNPCC and sporadic CRCs (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). Table 1 shows the reports from Iran that studied the frequency of MMR genes in both hereditary and sporadic colorectal cancers.…”

Section: Microsatellite Instability (Msi)mentioning

confidence: 99%

“…Table 1 shows the reports from Iran that studied the frequency of MMR genes in both hereditary and sporadic colorectal cancers. As it shows, the frequency of MSI in patients with HNPCC has been 29% -62.5% (9-25), there are not so many studies about the frequency of MSI in sporadic CRC from Iran; however, the reported frequencies of MMR have been from 19.4% to 66.6% (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25).…”

Section: Microsatellite Instability (Msi)mentioning

confidence: 99%

Molecular Biomarkers of Colorectal Cancer: A Review of Published Articles From Iran

Geramizadeh

2015

Ann Colorectal Res

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Context: Colorectal cancer is one of the most common cancers worldwide (the third most common cancer in the world) and is especially more common in Western countries; however, its incidence has been increased significantly during the last few years in Eastern countries such as Iran and considered as one of the five common cancers in this country. According to molecular pathways, numerous biomarkers have been identified for colorectal cancers which help patients' management. Evidence aquisition: In this study, we tried to review published articles about the molecular biomarkers of colorectal cancer from Iran. We searched medical databases such as google scholar, Scopus, PubMed, Magiran, SID and Iran Medex for keywords of "colon cancer, KRAS, BRAF, mismatch repair gene, Microsatellite instability, molecular genetics, molecular pathogenesis, biomarker and Iran" to find studies published about colorectal cancers from Iran regarding molecular biomarkers. Conclusion: This study showed that molecular biomarkers in colorectal cancer of Iranian patients are not so different from Western population.

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Colorectal cancer in Iran: immunohistochemical profiles of four mismatch repair proteins

Abstract: Along with the recommendations of the National Institute of Cancer, we recommend immunohistochemistry staining for MLH1, MSH2, PMS2, and MSH6 for determining the eligibility of patients for mutation analysis of MMR genes.

Cited by 18 publications

References 35 publications

Immunohistochemistry to Detect Hereditary Nonpolyposis Colorectal Cancer in Young Patients: the 7-Year Auckland Experience

Immunohistochemistry to Detect Hereditary Nonpolyposis Colorectal Cancer in Young Patients: the 7-Year Auckland Experience

Profile and Frequency of p53 Gene Alterations in Gastritis Lesions from Iran

Molecular Biomarkers of Colorectal Cancer: A Review of Published Articles From Iran

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