Colorectal cancer in Iran: Molecular epidemiology and screening strategies.

Dolatkhah, Roya; Dastgiri, Saeed; Bonyadi, Morteza; Kermani, Iraj Asvadi; Farassati, Faris

doi:10.1200/jco.2015.33.15_suppl.e12513

Cited by 29 publications

(36 citation statements)

References 39 publications

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“…The survival rate of CRC patient in Iran like other patients in the world depends on various factors such as demographic, pathologic and tumor characteristics, geographical distribution and gene mutation or having a family history (Dolatkhah et al, 2015;Rafiemanesh et al, 2016). But the most important factor for Iranian CRC patient is that they disease diagnosed in advanced stage (Aryaie et al, 2013;Dolatkhah et al, 2015). So this significant difference in 5-year survival rate may be due to, poorly established screening program like the fecal occult blood test, sigmoidoscopy and colonoscopy and limited accessibility in developing region (Sankaranarayanan et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Survival Rate of Colorectal Cancer in Iran: A Systematic Review and Meta-Analysis

Maajani

Khodadost

Fattahi

et al. 2019

Asian Pac J Cancer Prev

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2015). CRC is one of the most common cancers in Iran, which has increased in recent years. The incidence of this cancer in Iran is lower than other developed countries; however, in-recent decades, this rate has increased significantly. According to national reports of Iran cancer registration in 2009, colorectal cancer is the third most common cancer in women and the fourth most common cancer in men

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Section: Discussionmentioning

confidence: 99%

Survival Rate of Colorectal Cancer in Iran: A Systematic Review and Meta-Analysis

Maajani

Khodadost

Fattahi

et al. 2019

Asian Pac J Cancer Prev

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“…The overall incidence rate of CRC has been reported to significantly increase from 2004 to 2013 in both men and women 14 . CRC accounts for 9.7% of all cancers incidences 15 , which is increasing continuously 4 . Furthermore, it shows a younger age distribution in Iranian population rather than western countries 16 .…”

Section: Discussionmentioning

confidence: 99%

Investigating the prevalence of point mutations in the human mutL homolog 1 gene in colorectal cancer patients in the Northwest of Iran

Gholami¹,

Khaniani²,

Derakhsjan³

et al. 2019

GAMO

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Background/aims: Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of colorectal cancer (CRC) syndrome, in which the mutations in mismatch repair genes have been implicated in the disease etiopathogenesis. The aim of this study was to investigate the prevalence of human mutL homolog 1 (hMLH1) gene point mutations in patients with HNPCC in Northwest of Iran. Methodology: In this study, 30 patients with HNPCC were selected who fulfilled the Amsterdam II criteria. Moreover, 30 subjects were selected as the control group. Total RNA was extracted from peripheral blood sample, and complementary DNA (cDNA) was synthesized using specific primers. Screening of germline mutations within the hMLH1 gene was performed by direct cDNA sequencing. Functional evaluation was conducted through real-time polymerase chain reaction mRNA expression using the TaqMan Gene Expression Assay. Results: In this study, c.655A >G polymorphism was found in 13.3% of patients and 10% of the control group, while c.1959G > T polymorphism was found in only one of the patients. Two novel variants, including c.973C > A and c.1086C > A, were found in 13.3% and 20% of patients, respectively, that were identified for the 1 st time in this study. Moreover, the mRNA expression of hMLH1 gene in patients carrying the c.973C > A and c.1086C > A mutations showed no statistically significant difference in comparison to patients with no mutation and healthy controls. Conclusions: This study establishes that the frequency and type of mutations do not follow a similar pattern in other populations due to genetic and geographical differences.

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“…Colonoscopy is strongly recommended as a screening and early diagnostic tool, which dramatically benefits a reduction in CRC incidence and death rates in developed countries [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Hospital Prevalence of Colorectal Cancer among Colonoscopy Recipients Attending a Tertiary Hospital in Oman: A Cross-Sectional Study

Alsumait

Farsi

Waly

et al. 2020

The Scientific World Journal

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Purpose. Evidence from industrialized/developed countries showed that colorectal cancer (CRC) incidence rates have significantly dropped due to the widespread use of colonoscopy. In Arab countries, however, the CRC had been reported to have increased. Despite the concerted effort in the primary prevention and widespread use of colonoscopy, to our knowledge, there have been no reports of the prevalence rate of CRC among colonoscopy recipients from Oman. This study aims to explore the CRC prevalence estimates over selected sociodemographic characteristics among colonoscopy-recipients at a tertiary hospital in Oman over five years of follow-up. The regional variations in Oman were also examined in this study. Methods. This hospital-based cross-sectional study reviewed reports of colonoscopies performed over 5-years of retrospective follow-up at a tertiary hospital in Oman. CRC prevalence estimates were calculated over age, gender, governorate, and time of follow-up. Results. A total of 442 CRC cases were enumerated among 3701 colonoscopies, with an overall CRC prevalence estimate of 11.9 per 100 colonoscopies (95% CI: 10.9, 13.0). Gender-specific CRC prevalence was higher among males compared with females (13.3 vs. 10.5). Age-specific CRC prevalence increased with advancing age, from 2.8 among those less than 40 years of age to 26.5 among aged 70 years or more. Regional CRC prevalence was highest among residents in Batinah Governorate. Over the 5-years of follow-up, there was a slow rise in CRC prevalence with an annual increment of 0.59%. Conclusion. The study provides supportive evidence for a steady increase in CRC prevalence over age categories and years of follow-up and depicted the variations of gender-specific CRC prevalence estimates over increasing age categories. The study calls for timely formulation and adoption of national CRC screening programs centered on the colonoscopy use as primary prevention and maximizing its utilization and efficiency.

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Colorectal cancer in Iran: Molecular epidemiology and screening strategies.

Cited by 29 publications

References 39 publications

Survival Rate of Colorectal Cancer in Iran: A Systematic Review and Meta-Analysis

Survival Rate of Colorectal Cancer in Iran: A Systematic Review and Meta-Analysis

Investigating the prevalence of point mutations in the human mutL homolog 1 gene in colorectal cancer patients in the Northwest of Iran

Hospital Prevalence of Colorectal Cancer among Colonoscopy Recipients Attending a Tertiary Hospital in Oman: A Cross-Sectional Study

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