Colorectal Cancer in Northwestern Iran

Abstract

Background. Colorectal cancer is the third most prevalent cancer worldwide, which is less common in the Middle East; its prevalence demonstrated to be 7 persons per 100,000 populations in Iran. In this study, we aimed to investigate the clinicopathologic features of CRC patients in West Azerbaijan province of Iran. Methods. In this crosssectional study, 546 patients who underwent surgical procedures with the pathologic diagnosis of colorectal cancer in both academic and private hospitals of Urmia were enrolled. Results. The mean age at diagnosis was 55.2 ± 11.5 years. 23% had an age lower than forty years old. Rectal bleeding (26%), abdominal pain (25%), and large bowel obstruction (23%) were three most common presenting symptoms. 26% of patients presented with acute abdomen. 95% of tumors were adenocarcinoma, 4% were lymphoma, and 1% was other rare tumors. Regarding the stage of cancer according to TNM staging system, 6% of patients were in stage I, followed by 37% in stage II, 33% in stage III, and 24% in stage IV. In 44.5% of patients, the tumor was located in rectum. Conclusion. In west Azerbaijan province of Iran, patients with colorectal cancer present in younger age and more advanced stages in comparison with the developed countries.

An Overview of Clinical and Pathological Characteristics and Survival Rate of Colorectal Cancer in Iran

“…Accordingly, by excluding the patients with unknown staging status, the mean proportion of the patients with stage 0-I was 9%. The mean values for stages II, III, and IV were 39%, 36%, and 16%, respectively (11,13,15,19,20,24,29,31,32,37).…”

“…In these studies, 1229 patients had unknown tumor grade. Therefore, the distribution of tumor grade among the 4504 patients was as follows: grade 1, 52%; grade 2, 37%; and grade 3.11% (11,13,15,19,20,22,24,26,31,32,37,39). …”

“…By adding the rectosigmoid junction to rectal primary site, the mean proportion of the rectum as the primary site increased to 42%. Only 4 studies, including 7561 patients provided a detailed information regarding the sublocation of colon primary site as follows: Sigmoid colon 43%, ascending clon 21%, cecum 21%, descending colon 12%, and transverse colon 3% (11,13,15,16,(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). Out of the scope of the study (n = 21)a Eligible articles for review (n=27) a, Screening and diagnostic methods and colorectal polyps were the most frequent in this category.…”

Colorectal Cancer in Marrakech Tensift Elhaouz, Epidemiological and Anatomopathological Aspects, About 2584 Cases in 19 Years.

“…The CRC is generally in the histological 1038 form of adenocarcinoma. Nevertheless, other histological types exist but are much less common, such as neuroendocrine tumors, lymphomas, sarcomas, and squamous cell carcinomas, which can also be found in the rectum [49][50][51][52]. The incidence of each of these forms is difficult to calculate.…”

Detection of aberrant methylated SEPT9 and NTRK3 genes in sporadic colorectal cancer patients as a potential diagnostic biomarker

“…CRC is the 3rd and the 4th commonly diagnosed cancer in Iranian men and women, respectively (3). The lack of clinical manifestations in CRC patients until the late stages of cancer is a common disease characteristic, which results in poor prognosis and high mortality.…”