Colorectal cancer in patients with diabetes - epidemiology, pathophysiology and applications for clinical practice

Romanová, Alexandra; Malinovská, Jana; Lustigová, Michala; Urbanová, Jana; Brunerová, Ludmila; Vejtasová, Veronika; Verma, Anil; Duong, Tung A.; Šťovíček, Jan; Brož, Jan

doi:10.36290/vnl.2022.022

Cited by 3 publications

(1 citation statement)

References 57 publications

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“…Some studies reported induction of carcinogenesis in the individuals with diabetes pointing toward possible association 2 . In some cases, cancer and DM are diagnosed in the same individual 3,4 . DM has also been linked with different type of cancer such as colon, breast, rectal, pancreatic, gastric and several others 5 .…”

Section: Introductionmentioning

confidence: 99%

Interlinking of diabetes mellitus and cancer: An overview

Ahmad

Suhail

Ahmad

et al. 2023

Cell Biochemistry & Function

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Cancer and diabetes mellitus (DM) are among the leading causes of mortality and morbidity in the global arena. Lately, several studies demonstrated that DM could promote cancer. However, the exact mechanism(s) highlighting this association are largely untouched and require comprehensive detailing. In the present review, we aimed to explore and decipher the possible mechanism of DM an cancer association. Hyperglycemia could be a subordinate plausible explanation of carcinogenesis in the diabatic patient. It is well known that high glucose levels may help in cancer proliferation. In addition, chronic inflammation, the other well‐known factor of diabetes, could also play a role in carcinogenesis. Moreover, the numerous medicines to treat diabetes either increase or reduce cancer risk. Insulin is one of the potent growth factors that promotes cell propagation and induces cancer directly or via insulin like growth factor‐1. On the other hand, hyperinsulinemia leads to an increased activity of growth factor‐1 by inhibiting growth factor binding protein‐1. To improve cancer prognosis, individuals with diabetes should be screened to discover cancer at an early stage and treated appropriately.

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Section: Introductionmentioning

confidence: 99%

Interlinking of diabetes mellitus and cancer: An overview

Ahmad

Suhail

Ahmad

et al. 2023

Cell Biochemistry & Function

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Cutting-edge technology in medicine: preparation for colonoscopy in a patient with type 1 diabetes mellitus treated with a hybrid closed-loop insulin pump-continuous glucose monitor - case report and framework recommendations

Večeřová,

Neščáková,

Wasserbauer

et al. 2024

Vnitř Lék

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Koloskopické vyšetření je klíčová metoda pro prevenci, diagnostiku i léčbu onemocnění tlustého střeva. Součástí koloskopického vyšetření je příprava střeva před samotným zákrokem, spočívající ve vyprázdnění střeva pomocí perorálně užívaných lavážujících látek a s tím související přechodná změna diety. Tato příprava může u pacientů s diabetes mellitus vést k rozkolísání glykemie a riziku hypoglykemie. Kazuistika popisuje případ pacienta s diabetes mellitus 1. typu léčeného pomocí hybridního uzavřeného okruhu, který v rámci přípravy na koloskopické vyšetření využíval na základě dat z kontinuální monitorace glykemie sáčky s 5 gramy sacharózy k doplnění energie a stabilizaci glykemie. Glykemie se v průběhu přípravy pohybovaly v rozmezí 3,9-10,0 mmol/l, udržely se v doporučených hodnotách, pacient se tedy vyvaroval epizod hypoglykemií.Klíčová slova: kolonoskopie, diabetes mellitus 1. typu, hypoglykemie, uzavřený okruh pro dodávku inzulinu.Cutting-edge technology in medicine: preparation for colonoscopy in a patient with type 1 diabetes mellitus treated with a hybrid closed-loop insulin pump-continuous glucose monitor -case report and framework recommendations Colonoscopy is a key method for preventing, diagnosing, and treating colon diseases. The colonoscopic examination includes preparing the colon before the procedure, which involves emptying the bowel with orally administered lavage agents and the associated temporary change in diet. This preparation can lead to glycemic fluctuations and the risk of hypoglycemia in patients with diabetes mellitus. This case report describes the case of a patient with type 1 diabetes mellitus treated with a hybrid closed-loop system who used 5 grams of sucrose sachets during colonoscopic preparation to replenish energy and stabilize glucose based on continuous glucose monitoring data. Glycemia during preparation kept within recommended values 3.9-10.0 mmol/l.

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