Colorectal cancer in the elderly—surgical treatment and long-term survival

Schiffmann, Leif; Özcan, Sedat; Schwarz, Fabian; Lange, Jessica; Prall, Friedrich; Klar, E.

doi:10.1007/s00384-008-0457-5

Cited by 40 publications

(37 citation statements)

References 8 publications

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“…The higher postoperative morbidity rate in the older age patient group is because of the significant enhancement in common postoperative complications. Consistent with our observation, Schiffmann et al also revealed that the worse prognosis was in older CRC patients [24]. Older age may be associated with cardiovascular diseases or other medical illness [26], and with the significantly higher American Society of Anesthesiologists (ASA) classifications [27]; hence, older age is associated with poor overall survival, but not cancer-specific survival, in CRC patients.…”

Section: Discussionsupporting

confidence: 88%

Preoperative serum carcinoembryonic antigen, albumin and age are supplementary to UICC staging systems in predicting survival for colorectal cancer patients undergoing surgical treatment

Sun¹,

Chu²,

Cheng³

et al. 2009

BMC Cancer

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BackgroundThe aim of this study was to determine influence of prognostic factors in addition to UICC staging systems, on cancer-specific and overall survival rates for patients with colorectal cancer (CRC) undergoing surgical treatment.MethodsBetween January 1996 and December 2006, a total of 1367 CRC patients who underwent surgical treatment in Kaohsiung Medical University Hospital were analyzed. We retrospectively investigated clinicopathologic features of these patients. All patients were followed up intensively, and their outcomes were investigated completely.ResultsOf 1367 CRC patients, there were seven hundred and fifty-seven males (55.4%) and 610 (44.6%) females. The median follow-up period was 60 months (range, 3–132 months). A multivariate analysis identified that low serum albumin level (P = 0.011), advanced UICC stage (P < 0.001), and high carcinoembryonic antigen (CEA) level (P < 0.001) were independent prognostic factors of cancer-specific survival. Meanwhile, a multivariate analysis showed age over 65 years (P < 0.001), advanced UICC stage (P < 0.001), and high CEA level (P < 0.001) were independent prognostic factors of overall survival. Furthermore, combination of UICC stage, serum CEA and albumin levels as predictors of cancer-specific survival showed that the poorer the prognostic factors involved, the poorer the cancer-specific survival rate. Likewise, combination of UICC stage, age and serum CEA level as predictors of overall survival showed that the poorer the prognostic factors involved, the poorer the overall survival rate. Of these prognostic factors, preoperative serum CEA level was the only significant prognostic factor for patients with stage II and III CRCs in both cancer-specific and overall survival categories.ConclusionPreoperative serum albumin level, CEA level and age could prominently affect postoperative outcome of CRC patients undergoing surgical treatment. In addition to conventional UICC staging system, it might be imperative to take these additional characteristics of factors into account in CRC patients prior to surgical treatment.

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Section: Discussionsupporting

confidence: 88%

Preoperative serum carcinoembryonic antigen, albumin and age are supplementary to UICC staging systems in predicting survival for colorectal cancer patients undergoing surgical treatment

Sun¹,

Chu²,

Cheng³

et al. 2009

BMC Cancer

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“…In contrast, data on 5-year cancer-specific survival in the elderly are conflicting. Some studies present similar cancer-specific and diseasefree survival figures in all age groups undergoing curative surgery for colorectal cancer [7,8], while others have found impaired survival in the elderly [9]. These results suggest that elderly patients should be treated with the same surgical strategy as their younger counterparts, at least as long as there is no severe comorbidity.…”

Section: Introductionmentioning

confidence: 88%

Management of colon cancer in the elderly: a population‐based study

et al. 2014

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“…[6][7][8][9][10] However, the information on tumor features and prognosis for older patients from the developing countries is relatively scarce. In addition, the clinicopathological attributes of this disease in Asian patients are different from the rest of the world.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Factors Associated with Prognosis After Colorectal Cancer Resection in 174 Chinese Elderly Patients

Jiang

Qiu

et al. 2011

Journal of Gastrointestinal Surgery

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Colorectal cancer in the elderly—surgical treatment and long-term survival

Abstract: The age of patients does not seem to be a prognostic factor for perioperative results; furthermore, the long-term results rather depend on the stage of disease and on adjuvant or palliative treatment, respectively, than on age.

Cited by 40 publications

References 8 publications

Preoperative serum carcinoembryonic antigen, albumin and age are supplementary to UICC staging systems in predicting survival for colorectal cancer patients undergoing surgical treatment

Preoperative serum carcinoembryonic antigen, albumin and age are supplementary to UICC staging systems in predicting survival for colorectal cancer patients undergoing surgical treatment

Management of colon cancer in the elderly: a population‐based study

Analysis of Factors Associated with Prognosis After Colorectal Cancer Resection in 174 Chinese Elderly Patients

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