Colorectal Cancer Localization in Young Patients: Should We Expand the Screening Program?

Savas, Nurten; Dağli, U; Akbulut, Sabiye; Yüksel, Osman; Şahın, Burhan

doi:10.1007/s10620-006-9432-6

Cited by 22 publications

(18 citation statements)

References 25 publications

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“…In our study, the proportion of patients who were less than 40 years-of-age was 11%. This proportion in a Turkish study was 13% (Savas et al, 2007). Recent studies in Indian population showed that even within a country, this proportion might highly vary from 12.6% to 39% (Nath et al, 2009;Peedikayil et al, 2009;Gupta et al, 2010).…”

Section: Discussionmentioning

confidence: 83%

Clinical, Endoscopic and Pathogical Characteristics of Early-Onset Colorectal Cancer in Vietnamese

Quach¹,

Nguyen²

2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 83%

Clinical, Endoscopic and Pathogical Characteristics of Early-Onset Colorectal Cancer in Vietnamese

Quach¹,

Nguyen²

2012

Asian Pacific Journal of Cancer Prevention

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“…[5][6][7][8][9] Other reports have found an equivalent or better cancer-specific survival rates in young patients compared with older patients despite presenting with advanced stage disease. 8,10 The limited literature data are also conflicting with regards to the more common locations of colorectal carcinoma, with some indicating increased frequency of proximal right-sided colorectal carcinoma 11 while others demonstrating increased frequency of rectal and rectosigmoid carcinoma. 3,12 Most of the published data are confounded by inclusion of hereditary colorectal carcinoma, particularly Lynch syndrome-associated colorectal carcinomas, which have differing genetic events leading to tumorigenesis and often have improved survival compared with non-syndromic colorectal carcinoma.…”

mentioning

confidence: 99%

Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features

et al. 2012

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Recent literature suggests an increasing incidence of colorectal carcinoma in young patients. We performed a histologic, molecular, and immunophenotypic analysis of patients with sporadic early-onset (r40 years of age) colorectal carcinoma seen at our institution from the years 2000-2010 and compared these tumors to a cohort of consecutively resected colorectal carcinomas seen in patients 440 years of age. A total of 1160 primary colorectal adenocarcinomas were surgically resected for the years 2000 through 2010. Of these, 75 (6%) were diagnoses in patients r40 years of age of which 13 (17%) demonstrated abnormalities in DNA mismatch repair, 4 (5%) were in patients with known germline genetic disorders (two patients with familial adenomatous polyposis, one patient with juvenile polyposis, and one patient with Li-Fraumeni syndrome), and three patients (4%) had long-standing chronic inflammatory bowel disease. The sporadic early-onset colorectal carcinoma group comprised a total of 55 patients (55/1160, 5%) and were compared with a control group comprising 73 consecutively resected colorectal carcinomas with proficient DNA mismatch repair in patients 440 years of age. For the early-onset colorectal carcinoma group, most cases (33/55, 60%) were diagnosed between the age of 35 and 40 years of age. Compared with the control group, the early-onset colorectal carcinoma group was significantly different with respect to tumor location (Po0.007) with 80% (44/55 cases) identified in either the sigmoid colon (24/55, 44%) or rectum (20/55, 36%). Morphologically, early-onset colorectal carcinomas more frequently displayed adverse histologic features compared with the control colorectal carcinoma group such as signet ring cell differentiation (7/55, 13% vs 1/73, 1%, P ¼ 0.021), perineural invasion (16/55, 29% vs 8/73, 11%, P ¼ 0.009) and venous invasion (12/55, 22% vs 4/73, 6%, P ¼ 0.006). A precursor adenomatous lesion was less frequently identified in the early-onset colorectal carcinoma group compared with the control group (19/55, 35% vs 39/73, 53%, P ¼ 0.034). Of the early-onset colorectal carcinomas, only 2/45 cases (4%) demonstrated KRAS mutations compared with 11/73 (15%) of the control group colorectal adenocarcinomas harboring KRAS mutations, although this difference did not reach statistical significance (P ¼ 0.13). BRAF V600E mutations were not identified in the early-onset colorectal carcinoma group. No difference was identified between the two

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“…Previous studies underlined the significance of heritance as an indicator of EOCRC [11,12] . Supporting these views, early-onset and hereditary forms of CRC demonstrate similar well-known pathological features [11,13] . Nevertheless, the current knowledge is that EOCRC is a heterogeneous disease with both familial and sporadic cases.…”

Section: Molecular Pathogenesis Of Eocrcmentioning

confidence: 63%

“…These tumors are pathologically recognized with lowgrade tumor differentiation, mucinous component and high signet ring cells frequency [11,13] . Polyp development is contently observed during the follow-up period of EOCRC [10] .…”

Section: Molecular Pathogenesis Of Eocrcmentioning

confidence: 99%

Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer

Tezcan

Tunca

et al. 2016

WJGO

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Colorectal cancer (CRC) is the third most frequent cancer type and the incidence of this disease is increasing gradually per year in individuals younger than 50 years old. The current knowledge is that early-onset CRC (EOCRC) cases are heterogeneous population that includes both hereditary and sporadic forms of the CRC. Although EOCRC cases have some distinguishing clinical and pathological features than elder age CRC, the molecular mechanism underlying the EOCRC is poorly clarified. Given the significance of CRC in the world of medicine, the present review will focus on the recent knowledge in the molecular basis of genetic and epigenetic mechanism of the hereditary forms of EOCRC, which includes Lynch syndrome, Familial CRC type X, Familial adenomatous polyposis, MutYH-associated polyposis, Juvenile polyposis syndrome, Peutz-Jeghers Syndrome and sporadic forms of EOCRC. Recent findings about molecular genetics and epigenetic basis of EOCRC gave rise to new alternative therapy protocols. Although exact diagnosis of these cases still remains complicated, the present review paves way for better predictions and contributes to more accurate diagnostic and therapeutic strategies into clinical approach.

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Colorectal Cancer Localization in Young Patients: Should We Expand the Screening Program?

Cited by 22 publications

References 25 publications

Clinical, Endoscopic and Pathogical Characteristics of Early-Onset Colorectal Cancer in Vietnamese

Clinical, Endoscopic and Pathogical Characteristics of Early-Onset Colorectal Cancer in Vietnamese

Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features

Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer

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