Colorectal cancer market

Smith, Richard; Renaud, R; Hoffman, Eric W.

doi:10.1038/nrd1419

Cited by 14 publications

(8 citation statements)

References 3 publications

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“…Compared to all cancer types, colorectal cancer is most frequent form of cancer in oncologic pathology [1]. At present, it is one of the main malignant cancers in the gastrointestinal tract, its shows 13% of all malignant tumors, so it is second most frequent cause of death related to cancer affecting men as women in the equal manner worldwide, developed and undeveloped Countries, and also it is estimated to overcome the death rate of heart diseases in the coming years [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Docking analysis of importin-11 homology model with the phyto compounds towards colorectal cancer treatment

Selvaraj¹

2020

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The authors state that they adhere with COPE guidelines on publishing ethics as described elsewhere at https://publicationethics.org/. The authors also undertake that they are not associated with any other third party (governmental or non-governmental agencies) linking with any form of unethical issues connecting to this publication. The authors also declare that they are not withholding any information that is misleading to the publisher in regard to this article.

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Section: Introductionmentioning

confidence: 99%

Docking analysis of importin-11 homology model with the phyto compounds towards colorectal cancer treatment

Selvaraj¹

2020

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“…1 Currently, it is the most common malignant cancer in the gastrointestinal tract, representing 13% of all malignant tumors, and it is considered the second most common cause of death related to cancer affecting men as women in the same manner worldwide, developed and undeveloped countries, and it is expected to overcome the mortality rate of heart diseases in the coming years. [2][3][4] It is a prevalent disease in those aged 65-74, with a higher prevalence in women 5 .…”

Section: Introductionmentioning

confidence: 99%

Colorectal cancer: a review

et al. 2017

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Colorectal cancer (CCR) is the third most common cancer worldwide in men and women, the second largest cause of death related to cancer, and the main cause of death in gastrointestinal cancer. The risk of developing this cancer is related to bad alimentary habits, smoking, intestinal inflammatory disease, polyps, genetic factors, and aging. Of the patients that are diagnosed with colorectal cancer 90% are older than 50, with a median age of 64 years; however, the disease is more aggressive in patients that are diagnosed at younger ages. According to the American Cancer Association, it was accounted for more than 49,700 deaths in 2015. The goal is to reduce the mortality rate with early diagnosis and treatment. Currently, the survival rate is used to predict a patient’s prognosis. The patient is considered to have a positive familial history if a first-degree relative has been diagnosed with colorectal cancer or colonic polyps before the age of 60, or also if two or more first-degree relatives have been diagnosed with cancer or polyps at any age. There are several methods for detecting colorectal cancer, such as the guaiac test, immunochemical test of stool, DNA stool test, sigmoidoscopy, colonoscopy, and barium enema. The stage in which the cancer is detected determines the prognosis, survival, and treatment of the patient. Provide a review about generalities, genetic basis, risk factors, protective factors, clinical course, diagnostic methods, therapy and survival in colorectal cancer. Conducted research from different databases such as PubMed, Medline, MedScape, on the definition, genetic factors, classification, risk factors, protective factors, diagnostic methods, epidemiology, survival and treatment of colorectal cancer. Articles from 2000 to 2017 were included using the following keywords.

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“…Colorectal cancer is the third most common malignancy worldwide [1] and the most common malignancy in the digestive tract [2]. It is also the second most frequent malignancy-related cause of death in both developed and developing countries and is predicted to surpass mortality from cardiovascular diseases in the future [2], [3], [4].…”

Section: Introductionmentioning

confidence: 99%

Association between VEGF Gene Polymorphism -634G>C and Risk of Colorectal Cancer

Tambunan

Siregar

Syam

2022

Open Access Maced J Med Sci

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BACKGROUND: Genetic and environmental factors play an important role in the pathogenesis of colorectal cancer. Angiogenesis is a central process in carcinogenesis and is affected by vascular endothelial growth factor (VEGF). Several genetic variations, such as polymorphism, may alter VEGF expression and influence the risk of colorectal cancer. AIM: The objective of this study was to determine the association between VEGF gene polymorphism -634G>C and risk of colorectal cancer. METHODS: A cross-sectional study was conducted at Haji Adam Malik general hospital and its sister hospitals. Subjects were obtained by consecutive sampling. Inclusion criteria for case and control groups were patients with colorectal cancer and healthy subject, respectively, aged 18 years or older and willing to participate in the study. Exclusion criteria were patients with systemic comorbidities or malignancies in other organs. Each subject undergoes an interview, colonoscopy, biopsy, serum VEGF level measurement, and VEGF polymorphism -634G>C evaluation. RESULTS: Eighty subjects were enrolled and distributed into case and control groups. Males were dominant in both groups, with a mean age of older than 55 years. Most lesions were in the rectum and 45% of subjects had moderately differentiated cancer. The median serum VEGF level in the case group was higher than the control group (2,175.1 pg/mL vs. 253 pg/mL; p < 0.001). VEGF gene polymorphism -634G > C was associated with the risk of colorectal cancer (p = 0.048). GG and GC genotypes had 1.89 times higher risk of colorectal cancer compared to the CC genotype. GG genotype and G allele had the highest serum VEGF levels. CONCLUSION: There is an association between VEGF gene polymorphism -634G>C and risk of colorectal cancer in this study.

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Colorectal cancer market

Cited by 14 publications

References 3 publications

Docking analysis of importin-11 homology model with the phyto compounds towards colorectal cancer treatment

Docking analysis of importin-11 homology model with the phyto compounds towards colorectal cancer treatment

Colorectal cancer: a review

Association between VEGF Gene Polymorphism -634G>C and Risk of Colorectal Cancer

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